A5017541279- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Sepsis Diagnosis and Treatment
- Cardiac Structural Anomalies and Repair
- Hemodynamic Monitoring and Therapy
- Family and Patient Care in Intensive Care Units
- COVID-19 Clinical Research Studies
- Tracheal and airway disorders
- Anesthesia and Sedative Agents
- Heart Failure Treatment and Management
- Electrical and Bioimpedance Tomography
- Anesthesia and Neurotoxicity Research
- Antifungal resistance and susceptibility
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare Decision-Making and Restraints
- Bone and Joint Diseases
- Emergency and Acute Care Studies
- SARS-CoV-2 and COVID-19 Research
- Fungal Infections and Studies
- Airway Management and Intubation Techniques
- Electrolyte and hormonal disorders
- Frailty in Older Adults
- Central Venous Catheters and Hemodialysis
Samsung Medical Center
2016-2025
Sungkyunkwan University
2016-2025
University of Milano-Bicocca
2024
National University College
2020
New Generation University College
2020
Seoul National University Bundang Hospital
2020
Johns Hopkins Medicine
2020
Johns Hopkins University
2020
Asan Medical Center
2020
Weatherford College
2020
The effects of convalescent plasma (CP) infusion, one the treatment options for severe Middle East respiratory syndrome coronavirus (MERS-CoV) infections, have not yet been evaluated.Serological responses CP-infused MERS patients during 2015 Korean outbreak at a tertiary care centre were evaluated. Serological activity was evaluated with anti-MERS-CoV enzyme-linked immunosorbent assay (ELISA) immunoglobulin (Ig)G, ELISA IgA, immunofluorescence IgM and plaque reduction neutralization test...
Abstract Background Timely administration of antibiotics is one the most important interventions in reducing mortality sepsis. However, administering within a strict time threshold all patients suspected with sepsis will require huge amount effort and resources may increase risk unintentional exposure to broad-spectrum without infection its consequences. Thus, controversy still exists on whether clinicians should target different time-to-antibiotics thresholds for versus septic shock....
BackgroundAfter the 2015 Middle East respiratory syndrome (MERS) outbreak in Korea, prediction of pneumonia development and progression to failure was emphasized control MERS outbreak.MethodsMERS-CoV infected patients who were managed a tertiary care center during Korean reviewed. To analyze predictive factors for failure, we evaluated clinical variables measured within three days from symptom onset.ResultsA total 45 included study: 13 (28.9%) did not develop pneumonia, 19 developed without...
The role of extracorporeal membrane oxygenation (ECMO) remains controversial in adult patients with refractory septic shock. We sought to describe the clinical outcomes supported by ECMO during shock conventional treatment. analysed consecutive shock, assisted an system between January 2005 and December 2013 a single-centre registry. primary outcome was survival hospital discharge. A total 32 (21 males) received support for Of these, 14 (43.8%) had undergone cardiopulmonary resuscitation...
Background COVID-19, which is accompanied by acute respiratory distress, multiple organ failure, and death, has spread worldwide much faster than previously thought. However, at present, it limited treatments. Objective To overcome this issue, we developed an artificial intelligence (AI) model of named EDRnet (ensemble learning based on deep neural network random forest models), to predict in-hospital mortality using a routine blood sample the time hospital admission. Methods We selected 28...
For the clinical application of semi-quantitative anti-SARS-CoV-2 antibody tests, analytical performance and titer correlation plaque reduction neutralization test (PRNT) need to be investigated. We evaluated PRNT titer-correlation one surrogate virus (sVNT) kit three chemiluminescent assays. measured total antibodies for receptor-binding domain (RBD) spike protein, nucleocapsid protein (NP), IgG RBD. All assays showed high detection SARS-CoV-2 infection, with a sensitivity ≥ 98% specificity...
Delirium is a common complication of older people in hospitals, rehabilitation and long-term facilities. To assess the worldwide use validated delirium assessment tools presence management protocols. Secondary analysis one-day point prevalence study on World Awareness Day, 15 March 2023. Cross-sectional online survey including Participating clinicians reported data delirium, protocols, assessments, delirium-awareness interventions, non-pharmacological pharmacological ward/unit-specific...
Background Sepsis‐induced cardiac dysfunction, known as septic cardiomyopathy, is a common complication associated with increased mortality. Cardiac troponins serve markers for myocardial injury and are frequently elevated in patients sepsis. However, the role of troponin elevation at sepsis recognition risk stratification remains controversial. Methods Results This nationwide multicenter prospective cohort study analyzed 2141 adult without prior cardiovascular disease from Korean Sepsis...
Sepsis is a major cause of mortality and morbidity in critically ill patients. Procalcitonin (PCT) C-reactive protein (CRP) are the most frequently used biomarkers sepsis. We investigated changes PCT CRP concentrations patients with sepsis to determine which biochemical marker better predicts outcome. retrospectively analyzed 171 episodes 157 severe septic shock who were admitted Samsung Medical Center intensive care unit from March 2013 February 2014. The primary endpoint was patient...
Physical therapy (PT) and early mobilization for critically ill patients have been popularized to decrease the length of hospital stay improve quality life after discharge. We reviewed our experience PT active on extracorporeal membrane oxygenation (ECMO) in terms its technical feasibility safety. Study endpoints were safety events during interruptions due unstable vital signs. Of eight patients, one patient (12.5%) had venoarterial ECMO, seven (87.5%) venovenous ECMO. Among total 62...
Although the utilization of extracorporeal membrane oxygenation (ECMO) is increasing and its technology evolving, only a few epidemiologic reports have described uses outcomes ECMO. The aim this study was to investigate changes in survival rate patients supported with ECMO for severe respiratory failure Korea. This multicenter on consecutive who underwent across 16 hospitals records all required acute between 2012 2015 were retrospectively reviewed, analyzed over time. During period, 5552...
Background: Data regarding delivery of evidence-based care to critically ill patients in Intensive Care Units (ICU) during the COVID-19 pandemic is crucial but lacking. This study aimed evaluate implementation rate ABCDEF bundle, which a collection six ICU initiatives are strongly recommended be incorporated into clinical practice, and diaries for with without infections ICUs, analyze impact on each element bundle independent associated factors. Methods: A world-wide 1-day point prevalence...
Abstract Background Numerous epidemiological studies investigating gender-dependent clinical outcomes in sepsis have shown conflicting evidence. This study aimed to investigate the effect of gender on in-hospital mortality due according age group. Methods used data from Korean Sepsis Alliance, an ongoing nationwide prospective multicenter cohort 19 participating hospitals South Korea. All adult patients diagnosed with emergency departments between September 2019 and December 2021 were...
Phosphoinositide 3-kinases (PI3Ks) contribute to the pathogenesis of asthma by regulating activation inflammatory mediators, cell recruitment and immune function. Recent findings have indicated that PI3Ks also regulate expression interleukin (IL)-17, which has been recognised as an important cytokine involved in airway inflammation. In present study, we investigated a role PI3Kδ regulation IL-17 allergic disease using murine model asthma. After ovalbumin inhalation, administration selective...
The objective of this observational study was to evaluate whether early intervention associated with improved long-term outcomes in critically ill patients cancer.Retrospective analysis prospectively collected data.A university-affiliated, tertiary referral hospital.Consecutive cancer who were managed by a medical emergency team before ICU admission between January 2010 and December 2012.None.During the period, 525 admitted respiratory failure (41.7%) severe sepsis or septic shock (40.6%)...
Background Although the weaning classification based on difficulty and duration of process has been evaluated in different type intensive care units (ICUs), little is known about clinical outcomes validity among three groups medical ICU. The objectives this study were to evaluate relevance its association with hospital mortality a ICU protocol-based program. Methods All consecutive patients admitted requiring mechanical ventilation (MV) for more than 24 hours prospectively registered...
In 2015, a large outbreak of Middle East respiratory syndrome (MERS) occurred in the Republic Korea. Half cases were associated with tertiary care university hospital.