Karla D. Krewulak

ORCID: 0000-0003-0300-4122
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About
Contact & Profiles
Research Areas
  • Intensive Care Unit Cognitive Disorders
  • Family and Patient Care in Intensive Care Units
  • Healthcare Decision-Making and Restraints
  • Anesthesia and Sedative Agents
  • Palliative Care and End-of-Life Issues
  • Iron Metabolism and Disorders
  • Grief, Bereavement, and Mental Health
  • Bacterial Genetics and Biotechnology
  • Emergency and Acute Care Studies
  • Sepsis Diagnosis and Treatment
  • Geriatric Care and Nursing Homes
  • Disaster Response and Management
  • COVID-19 and healthcare impacts
  • Cardiac, Anesthesia and Surgical Outcomes
  • Trace Elements in Health
  • Drug Transport and Resistance Mechanisms
  • Porphyrin Metabolism and Disorders
  • Ethics in Clinical Research
  • COVID-19 and Mental Health
  • Health Systems, Economic Evaluations, Quality of Life
  • Infant Development and Preterm Care
  • Protein Structure and Dynamics
  • Nosocomial Infections in ICU
  • Pain Management and Opioid Use
  • Ethics in medical practice

University of Calgary
2014-2025

Alberta Health Services
2019-2025

University of Milano-Bicocca
2024

Alberta Health
2019

University of California, San Diego
2019

Geriatric Research Education and Clinical Center
2019

Vanderbilt University Medical Center
2019

O'Brien Institute
2019

Institute of Public Health Zadar
2019

Libin Cardiovascular Institute of Alberta
2018

Peter Nydahl Keibun Liu Giuseppe Bellelli Julie Benbenishty Mark van den Boogaard and 95 more Gideon A. Caplan Chi Ryang Chung Muhammed Elhadi Mohan Gurjar Gabi Heras-La Calle Magdalena Hoffmann Marie‐Madlen Jeitziner Karla D. Krewulak Tanya Mailhot Alessandro Morandi Ricardo Kenji Nawa Esther S. Oh Marie Oxenbøll Collet Maria Carolina Paulino Heidi Lindroth Rebecca von Haken Ahmed Gaber Ahmed Abdalgany Sarah Magdy Abdelmohsen Amjad Aburaas Christina Aggar Bashir Abobaker Albakosh Hamza Ismail Ahmad Alhamdan Akram Waled Rajab M Aljbali Fareeda Al-Kandari Akram Alkaseek Doreen Anders Matthew W. Anderson Shelly Ashkenazy Thiago Avelino Kasia Bail Ashraf Bakri Alaa Mohamed Ali Baroum Bronagh Blackwood Jennifer Brendt-Müller Angelika Brobeil Richard Burke Tru Byrnes Stefano Cacciatore Margaret Cahill Maria Ana Canelas Ida Carroll Amy Conley Wright Maria Costello Shannon A. Cotton Mandy Couser A. Salgado Elizabeth Cusworth Vera Cvoro Jordanna Deosaran Merel Diebels Elaine A Docherty Vera von Dossow Megan Drennan Akram Amin Egdeer Patrick Eichelsheim Aissha Ali Saleh Elagili Saifaleslam Jamal Elsahl H. A. Elshaikh Christina Emme Matthias Thomas Exl Azza Fathi Melanie Feige Kirsten M. Fiest Michael Fong Mikita Fuchita Christine Gaffney Carola Giménez-Esparza Vich Nicole Feldmann Rachel Fitzgerald Neasa Fitzpatrick Michael Fong María Adela Goldberg Nienke M.S. Golüke Marinette van der Graaf Engelina Groenewald Renate Gross Constant Segers R. Hadi Qusai Ahmad Hasan Hamdan Bahaeddin Ben Hamida Monalyce Hamza Breanna Hetland Jane Hopkins John Hopkins Said A. Ibrahim Guglielmo Imbrìaco Shigeaki Inoue A Jeyaseelan Ali Kadhim S. Kohler Rens Kooken Anna Korompeli Lars Krüger Ayman Salim Abu Khutwah P. E. Lange

Delirium is a common complication of older people in hospitals, rehabilitation and long-term facilities. To assess the worldwide use validated delirium assessment tools presence management protocols. Secondary analysis one-day point prevalence study on World Awareness Day, 15 March 2023. Cross-sectional online survey including Participating clinicians reported data delirium, protocols, assessments, delirium-awareness interventions, non-pharmacological pharmacological ward/unit-specific...

10.1093/ageing/afae129 article EN Age and Ageing 2024-07-01

In response to the rapid spread of SARS-CoV-2, hospitals in Canada enacted temporary visitor restrictions limit COVID-19 and preserve personal protective equipment supplies. This study describes extent, variation, fluctuation Canadian adult intensive care unit (ICU) visitation policies before during first wave pandemic.

10.1007/s12630-021-02049-4 article EN cc-by-nc Canadian Journal of Anesthesia/Journal canadien d anesthésie 2021-06-30

Abstract Background Critically ill patients require complex care and experience unique needs during after their stay in the intensive unit (ICU). Discharging or transferring a patient from ICU to hospital ward back community (under of general practitioner) includes several elements that may shape outcomes overall experiences. The aim this study was answer question: what facilitate successful, high-quality discharge ICU? Methods This scoping review is an update published 2015. We searched...

10.1186/s13054-021-03857-2 article EN cc-by Critical Care 2021-12-17

Family-administered delirium detection tools may serve as valuable diagnostic adjuncts because family caregivers be better able than providers to detect changes in patient cognition and behaviour from pre-illness levels of functioning. The aim this pilot study was assess the feasibility acceptability family-administered critically ill patients.In single-centre tool validation conducted August September 2017, eligible used Family Confusion Assessment Method (FAM-CAM) Sour Seven questionnaire...

10.9778/cmajo.20180123 article EN CMAJ Open 2019-01-01

An NMR approach is described which yields the methyl resonance assignments of alanine, threonine, valine, leucine, and isoleucine residues in proteins with high sensitivity excellent resolution. The method relies on protein samples produced by bacterial expression using [1H,13C]-D-glucose ∼100% D2O, cost-effective ensures isotopic enrichment all possible groups. Magnetization transfer throughout methyl-containing side chains this labeling scheme due to level deuteration along amino acid...

10.1021/ja907706a article EN Journal of the American Chemical Society 2010-02-11

Background In clinical practice, a dichotomous approach to delirium identification may no longer be relevant when existing screening tools measure range of scores. The objective this study was compare the Confusion Assessment Method for Intensive Care Unit 7-item (CAM-ICU-7) and Delirium Screening Checklist (ICDSC) as measures spectrum severity in critically ill adult patients. Methods cross-sectional study, 218 patients underwent 641 paired assessments by bedside nurses (ICDSC, per usual...

10.1371/journal.pone.0242378 article EN cc-by PLoS ONE 2020-11-16

Objectives: To evaluate the diagnostic accuracy of family-administered tools to detect delirium in critically ill patients. Design: Diagnostic study. Setting: Large, tertiary care academic hospital a single-payer health system. Patients: Consecutive, eligible patients with at least one family member present (dyads) and Richmond Agitation-Sedation Scale greater than or equal –3, no primary direct brain injury, ability provide informed consent (both patient member), communicate research staff,...

10.1097/ccm.0000000000004367 article EN cc-by-nc-nd Critical Care Medicine 2020-04-23

Rationale: Restricted visitation policies during the first wave of coronavirus disease (COVID-19) pandemic have had a major impact on ways that intensive care unit (ICU) clinicians communicated with patients and their families, requiring use innovative strategies to adapt new communication structures. Objectives: The purpose this study is describe restricted identify could be used facilitate better within Canadian ICUs from perspective those affected. Methods: We conducted semistructured...

10.1513/annalsats.202107-877oc article EN cc-by-nc-nd Annals of the American Thoracic Society 2021-12-16

To assess the effect of family presence on prevalence and duration delirium in adults admitted to an ICU.Retrospective cohort study.Medical-surgical ICUs Alberta, AB, Canada.A population 25,537 unique patients at least once Alberta ICU.We obtained electronic health records consecutive (≥ 18 yr) one 14 medical-surgical ICU Canada, from January 1, 2014, December 30, 2018. Family was quantified using a validated algorithm categorized as: 1) physical ICU, 2) telephone call only, 3) no (reference...

10.1097/ccm.0000000000005657 article EN cc-by-nc-nd Critical Care Medicine 2022-08-26

Abstract Background Delirium, an acute brain dysfunction, is proposed to be highly prevalent in clinical care and shown significantly increase the risk of mortality dementia. Objectives To report on global prevalence clinically documented delirium delirium-related practices wards caring for paediatric adult patients healthcare facilities. Design A prospective, cross-sectional, 39-question survey completed World Delirium Awareness Day, 15 March 2023. Participants Clinicians or researchers...

10.1093/ageing/afae248 article EN cc-by-nc Age and Ageing 2024-11-01

IMPORTANCE: Nursing workforce changes, knowledge translation gaps, and environmental/organizational barriers may impact sepsis recognition management within the ICU. OBJECTIVES: To: 1) evaluate current ICU nursing of management, 2) explore individual environmental or organizational factors impacting using Theoretical Domains Framework (TDF), 3) describe perceived facilitators to patients with sepsis. DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional survey was administered nurses...

10.1097/cce.0000000000001200 article EN cc-by-nc-nd Critical Care Explorations 2025-01-01
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