A5059693822- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Hemodynamic Monitoring and Therapy
- Respiratory Support and Mechanisms
- Emergency and Acute Care Studies
- Machine Learning in Healthcare
- Nosocomial Infections in ICU
- Transplantation: Methods and Outcomes
- Anesthesia and Neurotoxicity Research
- Heart Failure Treatment and Management
- Electrical and Bioimpedance Tomography
- Cardiac Structural Anomalies and Repair
- Anesthesia and Sedative Agents
- Airway Management and Intubation Techniques
- Tuberculosis Research and Epidemiology
- Family and Patient Care in Intensive Care Units
- Bacterial Identification and Susceptibility Testing
- Pneumonia and Respiratory Infections
- Frailty in Older Adults
- Clinical Reasoning and Diagnostic Skills
- Cardiac, Anesthesia and Surgical Outcomes
- Healthcare Technology and Patient Monitoring
- Traumatic Brain Injury and Neurovascular Disturbances
Sungkyunkwan University
2018-2025
Samsung Medical Center
2018-2025
University of Ulsan
2022
Asan Medical Center
2022
Ulsan College
2022
ORCID
2018
Jeonbuk National University
2014-2016
Abstract Background Timely administration of antibiotics is one the most important interventions in reducing mortality sepsis. However, administering within a strict time threshold all patients suspected with sepsis will require huge amount effort and resources may increase risk unintentional exposure to broad-spectrum without infection its consequences. Thus, controversy still exists on whether clinicians should target different time-to-antibiotics thresholds for versus septic shock....
Background COVID-19, which is accompanied by acute respiratory distress, multiple organ failure, and death, has spread worldwide much faster than previously thought. However, at present, it limited treatments. Objective To overcome this issue, we developed an artificial intelligence (AI) model of named EDRnet (ensemble learning based on deep neural network random forest models), to predict in-hospital mortality using a routine blood sample the time hospital admission. Methods We selected 28...
The prevalence of obesity is increasing in the intensive care unit (ICU). Although a known risk factor for chronic kidney disease, its association with early sepsis-associated acute injury (SA-AKI) and their combined patient outcomes warrant further investigation.
Background Sepsis‐induced cardiac dysfunction, known as septic cardiomyopathy, is a common complication associated with increased mortality. Cardiac troponins serve markers for myocardial injury and are frequently elevated in patients sepsis. However, the role of troponin elevation at sepsis recognition risk stratification remains controversial. Methods Results This nationwide multicenter prospective cohort study analyzed 2141 adult without prior cardiovascular disease from Korean Sepsis...
This study investigated the changes in major etiologic organisms and clinical phenotypes of nontuberculous mycobacterial lung disease (NTM-LD) over a recent 15-year period Korea. The increase number patients with NTM-LD was primarily due to an Mycobacterium avium complex (MAC) (LD). Among MAC cases, proportion M. increased compared intracellulare, whereas incidence abscessus kansasii LD remained relatively stable. cases nodular bronchiectatic form fibrocavitary NTM-LD.
Abstract Background Numerous epidemiological studies investigating gender-dependent clinical outcomes in sepsis have shown conflicting evidence. This study aimed to investigate the effect of gender on in-hospital mortality due according age group. Methods used data from Korean Sepsis Alliance, an ongoing nationwide prospective multicenter cohort 19 participating hospitals South Korea. All adult patients diagnosed with emergency departments between September 2019 and December 2021 were...
The recently developed deep learning (DL)-based early warning score (DEWS) has shown potential in predicting deteriorating patients. We aimed to validate DEWS multiple centres and compare the prediction, alarming timeliness performance with modified (MEWS) identify patients at risk for in-hospital cardiac arrest (IHCA).
Abstract The role of high-mobility group box-1 (HMGB1) in outcome prediction sepsis is controversial. Furthermore, its association with necroptosis, a programmed cell necrosis mechanism, still unclear. purpose this study to identify the between plasma levels HMGB1 and severity clinical outcomes sepsis, examine correlation key executors necroptosis including receptor-interacting kinase 3 (RIPK3) mixed lineage domain-like- (MLKL) proteins. Plasma HMGB1, RIPK3, MLKL were measured enzyme-linked...
The quick sequential organ failure assessment (qSOFA) score is suggested to use for screening patients with a high risk of clinical deterioration in the general wards, which could simply be regarded as early warning score. However, comparison unselected admissions highlight benefits introducing qSOFA hospitals already using Modified Early Warning Score (MEWS) remains unclear. We sought compare MEWS predicting ward regardless suspected infection. predictive performance and in-hospital cardiac...
Frailty is a multidimensional syndrome that leads to an increase in vulnerability. Previous studies have suggested frailty associated with poor health-related outcomes. For screening, the Clinical Scale (CFS) simple tool widely used various translated versions. We aimed translate CSF into Korean and evaluated its contents concurrent validity.Translations back-translations of CFS were conducted independently. A multidisciplinary team decided final CFS-K. Between August 2019 April 2020, total...
Background Delirium frequently occurs among patients admitted to the intensive care unit (ICU). There is limited evidence support interventions treat or resolve delirium in who have already developed delirium. Therefore, early recognition and prevention of are important management critically ill patients. Objective This study aims develop validate a prediction model within 24 hours admission ICU using electronic health record data. The algorithm was named Prediction (PRIDE). Methods...
Non-occlusive mesenteric ischemia (NOMI) is a life-threatening acute condition that has an overall in-hospital mortality rate of up to 75%. Critically ill patients are often admitted intensive care units (ICUs) due shock, and these frequently at risk developing NOMI. The objective this study was determine the clinical features critically with NOMI evaluate factors for among patients.We reviewed electronic medical records 7,346 who underwent abdominal contrast-enhanced computed tomography...
Abstract Background Despite the known impact of cardiac function on sepsis outcomes, there is limited understanding how ejection fraction (EF) influences hospital mortality in patients with sepsis-induced cardiomyopathy. This study assesses severity dysfunction determined by echocardiography within first 24 hours diagnosis mortality. Methods In this retrospective cohort study, 2,504 diagnosed and who underwent were analyzed. Based EF, classified into normal (EF ≥ 50%), moderate (30% ≤ EF...
Latency in transferring patients from intensive care units (ICUs) to general wards impedes the optimal allocation of ICU resources, underscoring urgency initiatives reduce it. This study evaluates extent transfer latency and assesses potential benefits minimizing Transfer was measured as time between first request actual discharge at a single-center tertiary hospital 2021. Computer-based simulations cost analyses were performed examine how reducing could affect average hourly bed occupancy,...
The incidence of sepsis with identified fungal pathogens is increasing and associated higher morbidity mortality. Co-infection infections in COVID-19 patients attracting clinical attention. This study examines the epidemiology, risk factors, outcomes among pathogens. We conducted a nationwide cohort adult from Korean Sepsis Alliance Database South Korea between September 2019 December 2021. 407 documented pathogens, categorized according to presence hemato-oncologic malignancies. Of 11,981...
Background Mechanical power (MP) and ventilatory ratio (VR) are crucial metrics in the management of acute respiratory distress syndrome (ARDS). This study aimed to evaluate impact these factors on ICU mortality patients with ARDS undergoing pressure-controlled ventilation. Methods In this retrospective study, we included 600 adult who required mechanical ventilation for > 48 h between March 2018 February 2021 a tertiary referral hospital Korea. The MP was calculated using Becher's...
Abstract Aims Unplanned intensive care unit (ICU) readmissions contribute to increased morbidity, mortality, and healthcare costs. The severity of patient illness at ICU discharge may predict early readmission. Thus, in this study, we investigated the association cardiac (CICU) Sequential Organ Failure Assessment (SOFA) score with unplanned CICU readmission patients admitted CICU. Methods results We retrospectively reviewed hospital medical records 4659 who were from 2012 18. scores...
Abstract Background There is limited information about the outcomes of polymicrobial bloodstream infections in patients with sepsis. We aimed to investigate compared monomicrobial infections. Methods This study used data from Korean Sepsis Alliance Registry, a nationwide database prospective observational sepsis cohort. Adult September 2019 December 2021 at 20 tertiary or university-affiliated hospitals South Korea were analyzed. Results Among 3,823 infections, 429 them (11.2%) had The crude...
Background The understanding of shock indices in patients with septic is limited, and their values may vary depending on cardiac function. Methods This prospective cohort study was conducted across 20 university-affiliated hospitals (21 intensive care units [ICUs]). Adult (≥19 years) admitted to the ICUs during a 29-month period were included. index (SI), diastolic (DSI), modified (MSI), age (Age-SI) calculated at sepsis recognition (time zero) ICU admission. Left ventricular (LV) function...