A5101884096- Sepsis Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Anesthesia and Sedative Agents
- Intensive Care Unit Cognitive Disorders
- Immune Response and Inflammation
- Anesthesia and Neurotoxicity Research
- Airway Management and Intubation Techniques
- Cardiac Ischemia and Reperfusion
- Anesthesia and Pain Management
- Cardiac, Anesthesia and Surgical Outcomes
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Nausea and vomiting management
- Cardiac Arrest and Resuscitation
- Nosocomial Infections in ICU
- Hemodynamic Monitoring and Therapy
- Eicosanoids and Hypertension Pharmacology
- Cancer, Stress, Anesthesia, and Immune Response
- S100 Proteins and Annexins
- Cardiac Imaging and Diagnostics
- Adipokines, Inflammation, and Metabolic Diseases
- Advanced Glycation End Products research
- Veterinary Pharmacology and Anesthesia
- Bacterial Identification and Susceptibility Testing
- Thermal Regulation in Medicine
- Bioactive natural compounds
Chonnam National University Hospital
2015-2025
Chonnam National University
2011-2023
Yonsei University
2002-2023
Ulsan College
2023
University of Ulsan
2023
Asan Medical Center
2023
Pain and Rehabilitation Medicine
2009
University of Colorado Anschutz Medical Campus
2005
Seonam University
2004
Ohkawara Neurosurgical Hospital
1995
Abstract Background Timely administration of antibiotics is one the most important interventions in reducing mortality sepsis. However, administering within a strict time threshold all patients suspected with sepsis will require huge amount effort and resources may increase risk unintentional exposure to broad-spectrum without infection its consequences. Thus, controversy still exists on whether clinicians should target different time-to-antibiotics thresholds for versus septic shock....
High mobility group box 1 (HMGB1) is a novel late mediator of inflammatory responses that contributes to endotoxin-induced acute lung injury and sepsis-associated lethality. Although frequent complication severe blood loss, the contribution HMGB1 organ system dysfunction in this setting has not been investigated. In study, was detected pulmonary endothelial cells macrophages under baseline conditions. After hemorrhage, addition positively staining macrophages, neutrophils expressing were...
Abstract Background Numerous epidemiological studies investigating gender-dependent clinical outcomes in sepsis have shown conflicting evidence. This study aimed to investigate the effect of gender on in-hospital mortality due according age group. Methods used data from Korean Sepsis Alliance, an ongoing nationwide prospective multicenter cohort 19 participating hospitals South Korea. All adult patients diagnosed with emergency departments between September 2019 and December 2021 were...
The prevalence of obesity is increasing in the intensive care unit (ICU). Although a known risk factor for chronic kidney disease, its association with early sepsis-associated acute injury (SA-AKI) and their combined patient outcomes warrant further investigation.
Burnout among critical care physicians is an important issue that affects patient and staff well-being. This study, conducted by the Korean Society of Critical Care Medicine, aimed to investigate prevalence associated factors burnout intensivists fellows in South Korea. From May July 2019, a cross-sectional survey was 51 hospitals 79 intensive units offering subspecialty training medicine. Invitations were sent email text, responses collected using NownSurvey Google Forms. Of 502 invited...
The incidence of sepsis with identified fungal pathogens is increasing and associated higher morbidity mortality. Co-infection infections in COVID-19 patients attracting clinical attention. This study examines the epidemiology, risk factors, outcomes among pathogens. We conducted a nationwide cohort adult from Korean Sepsis Alliance Database South Korea between September 2019 December 2021. 407 documented pathogens, categorized according to presence hemato-oncologic malignancies. Of 11,981...
There is a lack of information on critical care in Korea. The aim this study was to determine the current status Korean intensive units (ICUs), focusing organization, characteristics admitted patients, and nurse physician staffing. Critical specialists charge all 105 specialty training hospitals nationwide completed questionnaire survey. Among ICUs, 56.4% were located or near capital city. Only 38 ICUs (17.3%) had with 5-day work week. average daytime nurse-to-patient ratio 1:2.7. Elderly...
Mortality rates associated with sepsis have increased progressively in Korea, but domestic epidemiologic data remain limited. The objective of this study was to investigate the characteristics, management and clinical outcomes patients Korea.This is a multicenter retrospective cohort study. A total 64,021 adult who visited an emergency department (ED) within one 19 participating hospitals during 1-month period were screened for eligibility. Among these, diagnosed based on third International...
Introduction: Bilirubin is a product of the heme catabolism pathway, and it excreted in bile removed from body through urine. has potent antioxidant properties but also plays role anti-inflammation by protecting against endotoxin-induced lung inflammation, down-regulating expression adhesion molecules, inhibiting infiltration inflammatory cells. Thus, bilirubin promising agent that could use inflammation disease treatment. The application on “two-hit” sepsis animal model been, to date,...
To investigate the impact of normothermia on compliance with sepsis bundles and in-hospital mortality in patients who present to emergency departments.Retrospective multicenter observational study.Nineteen university-affiliated hospitals Korean Sepsis Alliance participated this study. Data were collected regarding visited departments for during 1-month period. The divided into three groups based their body temperature at time triage department (i.e., hypothermia [< 36°C] vs [36-38°C]...
Abstract Background There is limited information about the outcomes of polymicrobial bloodstream infections in patients with sepsis. We aimed to investigate compared monomicrobial infections. Methods This study used data from Korean Sepsis Alliance Registry, a nationwide database prospective observational sepsis cohort. Adult September 2019 December 2021 at 20 tertiary or university-affiliated hospitals South Korea were analyzed. Results Among 3,823 infections, 429 them (11.2%) had The crude...
Based on sparse evidence, the current Surviving Sepsis Campaign guideline suggests that critically ill patients with sepsis be admitted to intensive care unit (ICU) within 6 h. However, limited ICU bed availability often makes immediate transfer difficult, and it is unclear whether all will benefit from early admission ICU. Therefore, purpose of this study was determine association between timing mortality in hospital-onset sepsis.This nationwide prospective cohort analyzed ICUs 19 tertiary...
<i>Background:</i> We determined the effect of urinary trypsin inhibitors (UTI) in regional myocardial ischemia/reperfusion (I/R) injury and its underlying mechanisms involving role prosurvival kinases such as phosphatidylinositol-3-OH (PI3K)-Akt extracellular signal-regulated (ERK 1/2) apoptotic p38 JNK. <i>Methods:</i> The rats were anesthetized subjected to an I/R insult consisting 30-min left anterior descending coronary artery (LAD) occlusion followed by...