A5002248606- Drug-Induced Adverse Reactions
- Asthma and respiratory diseases
- Sepsis Diagnosis and Treatment
- Intensive Care Unit Cognitive Disorders
- Contact Dermatitis and Allergies
- Acute Kidney Injury Research
- Family and Patient Care in Intensive Care Units
- Allergic Rhinitis and Sensitization
- Mycobacterium research and diagnosis
- Sleep and related disorders
- Respiratory Support and Mechanisms
- Pharmacological Effects of Natural Compounds
- Pneumonia and Respiratory Infections
- Pharmacovigilance and Adverse Drug Reactions
- Poisoning and overdose treatments
- Inhalation and Respiratory Drug Delivery
- Infectious Diseases and Mycology
- Lanthanide and Transition Metal Complexes
- IL-33, ST2, and ILC Pathways
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Tuberculosis Research and Epidemiology
- Dermatology and Skin Diseases
- Neonatal Respiratory Health Research
- Emergency and Acute Care Studies
- Pleural and Pulmonary Diseases
Seoul National University Hospital
2021-2024
Seoul National University
2021-2022
Background With the widespread use of gadolinium-based contrast agents (GBCAs), incidence allergic-like hypersensitivity reactions (HSRs) to GBCAs is increasing. Research on and risk factors for HSRs needed their safe use. Purpose To determine acute delayed discuss strategies prevention GBCAs. Materials Methods All cases media that occurred at Seoul National University Hospital from July 1, 2012, June 30, 2020, were assessed. Information including age, sex, GBCA type, onset, severity was...
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease that has no cure. Although mesenchymal stem cells (MSCs) have been reported to ameliorate inflammation and in mouse models, their mechanisms of action remain unknown. Therefore, we aimed determine the changes various immune cells, especially macrophages monocytes, involved effects MSC treatment on fibrosis.We collected analyzed explanted tissues blood from patients with IPF who underwent transplantation. After...
The prevalence of obesity is increasing in the intensive care unit (ICU). Although a known risk factor for chronic kidney disease, its association with early sepsis-associated acute injury (SA-AKI) and their combined patient outcomes warrant further investigation.
Based on sparse evidence, the current Surviving Sepsis Campaign guideline suggests that critically ill patients with sepsis be admitted to intensive care unit (ICU) within 6 h. However, limited ICU bed availability often makes immediate transfer difficult, and it is unclear whether all will benefit from early admission ICU. Therefore, purpose of this study was determine association between timing mortality in hospital-onset sepsis.This nationwide prospective cohort analyzed ICUs 19 tertiary...
As sleep disturbances are common in the intensive care unit (ICU), this study assessed quality ICU and identified barriers to sleep.Patients admitted ICUs of a tertiary hospital between June 2022 December who were not mechanically ventilated at enrollment included. The (QoS) home was on visual analog scale as part an eight-item survey, while QoS evaluated using Korean version Richards-Campbell Sleep Questionnaire (K-RCSQ). Good defined by score ≥50.Of 30 patients study, 19 reported <50....
Drug desensitization is helpful for patients who have experienced significant hypersensitivity reactions (HSRs) to antineoplastic agents. One-bag protocols, attracting attention in recent years, need be validated on their safety and efficacy a large number.One-bag procedures conducted from 2018 2020 were analyzed; outcomes the risk factors breakthrough (BTRs) assessed major drug types (platins, taxanes, monoclonal antibodies).A total of 1,143 one-bag performed 228 with 99% completion rate....
Transcriptomic analysis has been used to elucidate the complex pathogenesis of heterogeneous disease and may also contribute identify potential therapeutic targets by delineating hub genes. This study aimed investigate whether blood transcriptomic clustering can distinguish clinical immune phenotypes asthmatics, microbiome in asthmatics.Transcriptomic expression peripheral mononuclear cells (PBMCs) from 47 asthmatics 21 non-asthmatics was measured using RNA sequencing. A hierarchical...
Endotracheal suctioning is an essential but labor-intensive procedure, with the risk of serious complications. A brand new automatic closed-suction device was developed to alleviate workload healthcare providers and minimize those We evaluated clinical efficacy safety suction system in mechanically ventilated patients pneumonia. In this multicenter, randomized, non-inferiority, investigator-initiated trial, pneumonia were randomized (intervention) or conventional manual (control). The...
가려움은 임상의가 빈번하게 마주하는 흔하고 비특이적인 증상으로 삶의 질 저하와 밀접하게 연관되어 있다. 말초에서 염증반응, 물리적 자극, 항원 노출 등에 의해 시작되며, 다양한 매개물질과 감각신호전달 경로를 통해 시상과 대뇌피질로 전달되어 가려움이라는 자극을 느끼게 된다. 병적인 가려움을 일으키는 질환들은 크게 (1) 피부과적 질환, (2) 내과적 질환에 동반되는 가려움, (3) 신경병적 (4) 심인성 가려움의 4가지로 분류된다. 호소하는 환자가 있다면 우선 정확한 병력청취와 피부병변 유무에 대한 검진이 필요하며, 동반된 질환 평가를 위해 검사를 시행하여 감별 진단을 해야 한다. 기간에 따라서 분류하기도 하는데, 6주 이상 지속될 때 만성 가려움으로 간주한다. 급성 가려움과 두드러기는 주로 히스타민 작용에 발생하므로 항히스타민제 투여가 치료의 근간이 된다. 반면 대부분의 질환의 경우 히스타민과 연관성이 없으며 원인 따른 맞춤 치료가 필요하다(Table 6, Fig....
Abstract In vivo presentation of airway hyper-responsiveness (AHR) at the different time points allergic reaction is not clearly understood. The purpose this study was to investigate how AHR manifests in and lung parenchyma following exposure stimuli early late phases asthma after allergen exposure. Ovalbumin (OVA)-induced model established using 6-week female BALB/c mice. Enhanced pause measured with a non-invasive method assess AHR. dynamic changes were evaluated ultra-high-resolution...