A5079096786- Mycobacterium research and diagnosis
- Tuberculosis Research and Epidemiology
- Infectious Diseases and Mycology
- Gastrointestinal Bleeding Diagnosis and Treatment
- Quinazolinone synthesis and applications
- Medical Research and Treatments
- Infectious Diseases and Tuberculosis
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Gut microbiota and health
- Tracheal and airway disorders
- Intensive Care Unit Cognitive Disorders
- Electrolyte and hormonal disorders
- Sepsis Diagnosis and Treatment
- Diverticular Disease and Complications
- Microwave-Assisted Synthesis and Applications
- Lung Cancer Diagnosis and Treatment
- Pleural and Pulmonary Diseases
- Emergency and Acute Care Studies
- Neurological Complications and Syndromes
- Magnesium in Health and Disease
- Bipolar Disorder and Treatment
- Helicobacter pylori-related gastroenterology studies
- Transplantation: Methods and Outcomes
- Pulmonary Hypertension Research and Treatments
- Organ and Tissue Transplantation Research
Seoul National University Hospital
2008-2025
Harvard University
2024-2025
Biomedical Research Institute
2025
Seoul National University
2023-2024
Pulmonary and Critical Care Associates
2023
Abstract Between 2010 and 2021, the annual prevalence of nontuberculous mycobacterial (NTM) diseases in South Korea increased from 11.4 to 56.7 cases per 100 000 population. Prevalence population aged ≥65 years quadrupled 41.9 163.1 Accordingly, overall cost associated with NTM increased.
Abstract Background Whether antimicrobial treatment improves long-term survival in patients with Mycobacterium avium complex pulmonary disease (MAC-PD) is unclear. Methods We analyzed aged ≥18 years who were treated for MAC-PD at a tertiary referral center South Korea between 1 January 2009 and 31 December 2020. Treatment exposure was divided into 4 time intervals: <6, ≥6 to <12, ≥12 <18, months. Time-varying multivariable Cox proportional hazards models used calculate...
Posterior reversible encephalopathy syndrome (PRES) is a rare complication of lung transplantation with poorly understood risk factors and clinical characteristics. This study aimed to examine the occurrence, factors, data patients who developed PRES following transplantation. A retrospective analysis was conducted on 147 underwent between February 2013 December 2023. The were diagnosed based symptoms radiological findings. We compared baseline characteristics information, including primary...
Abstract In a cohort of 534 patients treated for Mycobacterium avium complex pulmonary disease, those who failed to achieve culture conversion were older, had higher proportions males and cavity presence, more likely receive clofazimine aminoglycosides, but less rifampicin, shorter overall treatment duration. Time-varying analysis individual drug effects on time identified rifampicin as being associated with reduced rate (adjusted hazard ratio, 0.959; 95% confidence interval, 0.924–0.995;...
Abstract Background The number of patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) is rapidly increasing globally, especially in the older population. However, there a dearth evidence regarding impact aging on treatment outcomes NTM-PD. Methods We analyzed consecutive who satisfied diagnostic criteria for Mycobacterium avium complex (MAC)-PD and received antibiotic between January 2009 December 2020 at tertiary referral hospital Korea. main were (1) long-term success,...
Abstract Background The therapeutic challenges posed by nontuberculous mycobacterial pulmonary disease (NTM-PD) contribute to an unmet medical need. In this study, we aimed investigate NTM-PD-specific metabolic pathways using serum metabolomics understand pathogenesis. Methods Mass spectrometry-based untargeted metabolomic profiling of from patients with NTM-PD (n = 50), bronchiectasis and healthy controls 60) was performed. Selected metabolites were validated independent cohort subjected...
Abstract Background Improving health-related quality of life (HRQOL) has emerged as a priority in the management nontuberculous mycobacterial pulmonary disease (NTM-PD). We aimed to evaluate HRQOL and its changes after 6 months’ treatment patients with NTM-PD. Methods The NTM-KOREA is nationwide prospective cohort enrolling initiating for NTM-PD 8 institutions across South Korea. conducted Quality Life–Bronchiectasis (QOL-B) at 6-month intervals evaluated baseline scores (higher indicate...
Antifibrotic therapy can slow disease progression (DP) in patients with idiopathic pulmonary fibrosis (IPF). However, the prognostic biomarkers for DP IPF receiving antifibrotic have not been identified. Therefore, we aimed to evaluate efficacy of serum Krebs von den Lungen-6 (KL-6) therapy. The clinical data 188 who initiated at three tertiary hospitals was retrospectively analyzed. defined as a relative decline forced vital capacity (FVC) ≥ 10%, diffusing carbon monoxide 15%, acute...
Rationale: The clinical implications of trehalose 6,6'-dimycolate (TDM) in nontuberculous mycobacterial pulmonary disease have not been studied. Objectives: To examine the presence TDM isolates obtained from patients with Mycobacterium avium complex (MAC) (PD) and its impact on severity treatment outcomes. Methods: We analyzed diagnoses MAC PD at Seoul National University Hospital between January 1, 2019, December 31, 2021. lipids were extracted time diagnosis using mass spectrometry. Mass...
Rationale: Imaging studies are widely performed when treating Mycobacterium avium complex pulmonary disease (MAC-PD); however, the clinical significance of post-treatment radiographic change is unknown. Objectives: To determine whether a deep neural network trained with tuberculosis could adequately score severity MAC-PD. Then, to examine relationships between and its from baseline long-term prognosis. Methods: We retrospectively collected chest radiographs adult patients MAC-PD treated for...
Abstract Background Clofazimine is suggested as a promising drug for the treatment of nontuberculous mycobacterial pulmonary disease. However, role clofazimine in severe Mycobacterium avium complex disease (MAC-PD) remains unclear. In this study, we investigated outcomes patients with MAC-PD treated regimens containing clofazimine. Methods This study included diagnosed at Seoul National University Hospital who underwent anti-mycobacterial between 1 January 2011 and 31 December 2022. We...
In critically ill patients, the most common manifestation of brain dysfunction is delirium, which independently associated with higher morbidity and mortality. While electrolyte imbalance one precipitating factors, impact hypomagnesemia on incidence delirium remains unknown.We retrospectively analyzed patients admitted to medical intensive care unit (ICU) a tertiary referral center between January June 2020. Patients ICU stay ≥48 hours aged 40-85 years were included. The primary outcome was...
Due to impaired cell-mediated immunity, solid organ transplantation (SOT) recipients are at increased risk of developing nontuberculous mycobacterial pulmonary disease (NTM-PD). However, the clinical course NTM-PD in SOT patients and impact on prognosis remain unclear.We analyzed who developed after receiving between January 2001 December 2020, a tertiary referral hospital South Korea. Baseline characteristics, course, were evaluated. Propensity score-matched analysis was performed assess...
Prolonged length of hospital stay (LOS) is associated with an increased risk hospital-acquired conditions and worse outcomes. We conducted a nationwide, multicenter, retrospective cohort study to determine whether prolonged hospitalization before developing sepsis has negative impact on its prognosis.
Abstract Objectives The impact of rheumatoid arthritis (RA) on nontuberculous mycobacterial pulmonary disease (NTM-PD) has not been well established. In this study, we investigated the clinical course NTM-PD in patients with RA and prognosis NTM-PD. Methods We analyzed who developed after being diagnosed from January 2004 to August 2023 at a tertiary referral hospital South Korea. patient’s baseline characteristics, course, were evaluated. An optimal matching analysis was performed measure...
Abstract Background The immunologic features of nontuberculous mycobacterial pulmonary disease (NTM-PD) are largely unclear. This study investigated the NTM-PD using digital spatial profiling techniques. Methods Lung tissues obtained from six patients with between January 1, 2006, and December 31, 2020, at Seoul National University Hospital were subjected to RNA sequencing. Cores peribronchial areas stained CD3, CD68, DNASyto13, gene expression whole-transcriptome level was quantified PCR...
Abstract Background The microbiota may provide biomarkers for clinical outcomes in chronic respiratory conditions, though its role Mycobacterium abscessus pulmonary disease (PD) remains largely unknown. We aimed to identify microbial signatures fecal and sputum microbiotas associated with treatment response M PD. Methods prospectively enrolled patients undergoing antibiotic therapy, collecting samples at baseline, 2 weeks, 6 months. Using 16S rRNA amplicon sequencing, we analyzed diversity...