A5071379181- Drug-Induced Adverse Reactions
- Urticaria and Related Conditions
- Contact Dermatitis and Allergies
- Pharmacovigilance and Adverse Drug Reactions
- Autoimmune Bullous Skin Diseases
- Asthma and respiratory diseases
- Eosinophilic Disorders and Syndromes
- Tuberculosis Research and Epidemiology
- Pharmaceutical studies and practices
- Food Allergy and Anaphylaxis Research
- Health and Wellbeing Research
- SARS-CoV-2 and COVID-19 Research
- Allergic Rhinitis and Sensitization
- Mast cells and histamine
- Acute Kidney Injury Research
- Pharmaceutical Practices and Patient Outcomes
- Chemotherapy-related skin toxicity
- Occupational exposure and asthma
- Monoclonal and Polyclonal Antibodies Research
- Academic integrity and plagiarism
- Biosimilars and Bioanalytical Methods
- Pediatric health and respiratory diseases
- Muscle and Compartmental Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Lanthanide and Transition Metal Complexes
University of Ulsan
2023-2024
Ulsan College
2023-2024
Ulsan University Hospital
2023-2024
Seoul National University Hospital
2017-2024
Inha University
2023
Asan Medical Center
2023
Gachon University
2023
Seoul National University
2011-2022
New Generation University College
2013-2020
General Department of Preventive Medicine
2020
Background Multicenter studies may be required for establishing guidelines safe usage of iodinated contrast media (ICM). Purpose To identify the prevalence, patterns, risk factors, and preventive measures ICM-related hypersensitivity reactions (HSRs). Materials Methods Between March 2017 October 2017, a total 196 081 patients who underwent ICM administration were enrolled from seven participating institutions. The occurrence HSRs baseline patient information recorded. χ2 Student t test...
To evaluate the risk of fractures related with zolpidem in elderly insomnia patients.Health claims data on entire South Korean population from January 2005 to June 2006 were extracted Health Insurance Review and Assessment Service database. We applied a case-crossover design. Cases defined as patients who had fracture diagnosis. set hazard period 1 day length prior date four control periods same at 5, 10, 15, 20 weeks date. Time independent confounding factors such age, gender, lifestyle,...
Purpose To evaluate premedication protocols involving administration of antihistamine and multidose corticosteroid that have been widely used in prevention recurrent hypersensitivity reactions (HSRs) to iodinated contrast media (ICM); an evidence-based optimal preventive strategy customized for patients with mild cases has not yet established. Materials Methods The outcomes HSR who subsequently underwent material-enhanced computed tomography (CT) between January 2012 December 2015 were...
Background With the widespread use of gadolinium-based contrast agents (GBCAs), incidence allergic-like hypersensitivity reactions (HSRs) to GBCAs is increasing. Research on and risk factors for HSRs needed their safe use. Purpose To determine acute delayed discuss strategies prevention GBCAs. Materials Methods All cases media that occurred at Seoul National University Hospital from July 1, 2012, June 30, 2020, were assessed. Information including age, sex, GBCA type, onset, severity was...
Few studies have investigated the incidence of anaphylaxis induced by individual or structurally similar cephalosporins. The aims study were to assess cephalosporin-induced and evaluate clinical efficacy screening skin tests.In this retrospective cohort study, we obtained information on total cephalosporin use in intravenous recipients 12 general hospitals between 2013 2015. Cephalosporins divided into 4 groups according side-chain structures. was assessed for each cephalosporin, generation,...
Abstract Purpose Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but serious condition that systematically damages various internal organs through T‐cell–mediated immunological drug reactions. We aimed to investigate whether clinical manifestations of DRESS differ according culprit drugs. Methods retrospectively analyzed data from 123 patients probable/definite based on the RegiSCAR criteria (January 2011 July 2016). The were obtained Korean Severe Cutaneous...
Severe cutaneous adverse reactions (SCARs), including Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia systemic symptoms (DRESS) to antiepileptic (AED), are rare, but result in significant morbidity mortality. We investigated the major culprit drugs, clinical characteristics, course outcomes of AED-induced SCARs using a nationwide registry Korea.A total 161 patients from 28 referral hospitals were analyzed. The causative AEDs, organ...
Although severe cutaneous adverse drug reactions (SCARs) are rare, they associated with high morbidity and mortality, thus early diagnosis treatment critical for improving prognoses. However, few studies have reported the characteristics of SCARs in children. Thus, we aimed to evaluate clinical characteristics, current management prognosis pediatric SCARs.We analyzed data Korean registry, which was built retrospectively 2016 SCAR cases treated 34 tertiary referral university hospitals during...
PURPOSE Anti-tuberculosis drugs (ATDs) can cause severe cutaneous adverse reactions (SCARs) such as Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN), and drug reaction with eosinophilia systemic symptoms (DRESS). Underlying tuberculous infection co-administration of multiple may contribute to the complexity ATD-related SCARs. This study aimed investigate clinical characteristics outcomes METHODS We analyzed SCAR cases in 2010-2015, selected from a web-based Database Korean...
To evaluate the current status of managing adverse reactions to iodinated contrast media (ICM) for computed tomography in referral hospitals South Korea compared with other countries.
Background: Although several studies deal with breakthrough reactions (BTRs) in patients contrast media (CM) hypersensitivity reactions, the phenomenon is still unclear.Therefore, this study aimed to analyse depth BTR two countries. Methods:We retrospectively analysed electronic medical records of in-and outpatients (random sample enrolment) from academic hospitals tertiary care (Seoul/South Korea, a special monitoring system exclusively for CM hypersensitivity, and Bern/Switzerland,...
Objectives Avoiding culprit agents is recommended for subjects who have had previous hypersensitivity reaction (HSR) to low-osmolar contrast media (LOCM). However, the guidelines choosing optimal alternatives not been determined. We investigated outcomes of reexposure in patients with immediate HSRs provide a safe option. Materials and Methods The were assessed cohort LOCM-associated HSR based on skin testing results presence common N -(2,3-dihydroxypropyl) carbamoyl side chain. Results...
Remdesivir is a US Food and Drug Administration-approved drug for coronavirus disease 2019 (COVID-19). Clinical trials were conducted under strictly controlled situations selected population, their reported adverse events may not fully represent conditions in real-world patients. We aimed to estimate the incidence of (ADEs) associated with remdesivir hospitalized patients COVID-19, including vulnerable subpopulations, such as those impaired renal or hepatic function pregnant women.This...
Objectives The aim of this study was to investigate whether a medium high degree total physical activity and indoor were associated with reduced all-cause cardiovascular mortality among elderly Korean women. Methods A prospective cohort done evaluate the association between mortality. made up (≥65 years age) subjects. Baseline information collected self-administered questionnaire linked death certificates retrieved from database. Cox proportional hazard models used estimate ratios (HRs) 95%...
Background Eosinophils are major effector cells of allergic disease and excellent markers eosinophilic inflammation. Accurate reliable biomarkers helpful in the diagnosis, treatment, control disease. Objective This study aimed to investigate an alternate marker inflammation, eosinophil-derived neurotoxin (EDN), a number diseases. Methods Three hundred ninety-six elementary school-age children with various conditions were recruited for this study. Subgroups included food allergies (FAs),...
An adverse drug reaction (ADR) is defined as an unintended harmful to a drug. 1 With advances in medicine, people are taking more medications, and events (ADEs) rapidly increasing.Lazzarou, et al. 2 reported that ADRs the fourth leading cause of death US, after heart disease, cancer, stroke.According Global Burden Disease report 2013, number worldwide ADR-related deaths was 142000 1.5-fold increase over
Drug desensitization is helpful for patients who have experienced significant hypersensitivity reactions (HSRs) to antineoplastic agents. One-bag protocols, attracting attention in recent years, need be validated on their safety and efficacy a large number.One-bag procedures conducted from 2018 2020 were analyzed; outcomes the risk factors breakthrough (BTRs) assessed major drug types (platins, taxanes, monoclonal antibodies).A total of 1,143 one-bag performed 228 with 99% completion rate....