BackgroundThe performance of a deep learning (DL) algorithm should be validated in actual clinical situations, before its implementation.PurposeTo evaluate the DL for identifying chest radiographs with clinically relevant abnormalities emergency department (ED) setting.Materials and MethodsThis single-center retrospective study included consecutive patients who visited ED underwent initial radiography between January 1 March 31, 2017. Chest were analyzed commercially available algorithm. The...

Purpose To evaluate premedication protocols involving administration of antihistamine and multidose corticosteroid that have been widely used in prevention recurrent hypersensitivity reactions (HSRs) to iodinated contrast media (ICM); an evidence-based optimal preventive strategy customized for patients with mild cases has not yet established. Materials Methods The outcomes HSR who subsequently underwent material-enhanced computed tomography (CT) between January 2012 December 2015 were...

To investigate the diagnostic performance of quantitative ultrasound (US) parameters for assessment hepatic steatosis in patients with nonalcoholic fatty liver disease (NAFLD) using magnetic resonance imaging proton density fat fraction (MRI-PDFF) as reference standard.In this single-center prospective study, 120 clinically suspected NAFLD were enrolled between March 2019 and January 2020. The participants underwent US examination radiofrequency (RF) data acquisition chemical shift-encoded...

Abstract Ultrasonography (US) has been considered image of choice for gallbladder (GB) polyp, however, it had limitations in differentiating between nonneoplastic polyps and neoplastic polyps. We developed investigated the usefulness a deep learning-based decision support system (DL-DSS) differential diagnosis GB on US. retrospectively collected 535 patients, they were divided into development dataset (n = 437) test 98). The binary classification convolutional neural network model was by...

Radiofrequency ablation (RFA) is widely employed for managing recurrent hepatocellular carcinoma (HCC) following transarterial chemoembolization (TACE). However, local tumor progression (LTP) after treatment remains a significant challenge. This study evaluates the efficacy of saline-perfused bipolar RFA using twin internally cooled-perfusion (TICP) electrodes in HCC post-TACE. Between September 2017 and January 2019, 100 patients with 105 nodules (mean diameter: 1.6 ± 0.5 cm) were...

A new class of sila-substituted 1,3,4-oxadiazoles was synthesized and evaluated for antiallergic activity using RBL-2H3 as the in vitro model vivo anaphylactic mouse model. We observed that compound 5c effectively suppressed DNP-HSA-induced mast cell degranulation, compared to carbon analogue 9, also expression TNF-α mRNA Akt phosphorylation antigen-stimulated cells. studied effect an passive cutaneous anaphylaxis (PCA) The suppression by more effective than diphenylhydramine (DPH), a...

Background Tumor stiffness (TS), measured by magnetic resonance elastography (MRE), could be associated with tumor mechanical properties and grade. Purpose To determine whether TS obtained using MRE is survival in patients single nodular hepatocellular carcinoma (HCC) after hepatic resection (HR). Study Type Retrospective. Population In all, 95 pathologically confirmed HCCs. Field Strength/Sequence 1.5T/ 3D spin‐echo echo‐planar imaging MRE. Assessment values of the whole (TS‐WT) a solid...

Abstract Background To investigate the potential value of volumetric iodine quantification using preoperative dual-energy computed tomography (DECT) for predicting microvascular invasion (MVI) hepatocellular carcinoma (HCC). Methods This retrospective study included patients with single HCC treated through surgical resection who underwent DECT. Quantitative DECT features, including normalized concentration (NIC) to aorta and mixed-energy CT attenuation in arterial phase, were...

Background Diagnostic performance of the Liver Imaging Reporting and Data System tumor in vein (LR-TIV) category at CT and/or MRI has not yet been evaluated, to knowledge authors. Purpose To assess diagnostic LR-TIV detecting macroscopic tumors veins (TIVs) hepatobiliary contrast agent-enhanced (HBA) MRI, with pathologic results used as reference standard. Materials Methods Between January 2010 December 2019, consecutive patients or without TIV who underwent both HBA before hepatic resection...

Background To predict poor overall survival (OS) in pancreatic adenocarcinoma (PAC) who underwent FOLFIRINOX (5-fluorouracil/leucovorin/irinotecan/oxaliplatin) using clinical and computed tomography (CT) findings. Methods A total of 189 patients with PAC received were retrospectively included. Two reviewers assessed CT findings resectability based on National Comprehensive Cancer Network guidelines. They determined tumor size changes according to Response Evaluation Criteria Solid Tumors...

To assess intra- and inter-observer reproducibility of a new point shear wave elastography technique (pSWE, S-Shearwave, Samsung Medison) compare its accuracy in assessing liver stiffness (LS) with an established pSWE (Virtual Touch Quantification, VTQ).Thirty-three patients were enrolled this Institutional Review Board-approved prospective study. LS values measured by VTQ on Acuson S2000 system (Siemens Healthineer) S-Shearwave RS-80A (Samsung the same session, followed two further sessions...

Objectives Currently, the prevention of recurrent immediate hypersensitivity reactions (HSRs) to contrast media (CM) requests premedication and changing culprit agent. However, strategies for HSRs gadolinium-based magnetic resonance agents (GBCAs) have not yet been established. This study aimed evaluate effectiveness agent single-dose HSR recurrence in patients with a history mild GBCA. Materials Methods The outcomes GBCA who subsequently underwent enhanced imaging between October 2012 July...

현재 전 세계적으로 알러지 질환은 급격히 증가하고 있는 추세이다. 기존의 길항제나 항원 특이적 면역 치료법의 부작용으로 인하여 항 작용에 효과적인 천연 기능성 물질에 대한 연구가 질환 치료의 유망한 분야로 여겨지고 있다. 비만세포는 히스타민이나 아라키돈 산, 그리고 염증성 사이토카인 등을 방출하는 반응에 주요하게 작용하는 효과세포이다. 우리는 참당귀의 뿌리로부터 추출한 노다케닌의 반응 억제효과에 대해서 연구하였다. 노다케닌을 이용하여 비만세포에서의 탈 과립현상 억제 효과를 측정한 결과, 비만세포에서 노다케닌이 탈과립의 표지인 <TEX>${\beta}$</TEX>-hexosaminidase의 방출량을 농도 의존적으로 억제하는 것을 관찰하였고, 이러한 탈과립 현상이 다양한 중 IL-4과 TNF-<TEX>${\alpha}$</TEX>의 양을 감소시킴으로써 매개된다는 사실을 RT-PCR을 통해 확인하였다. 또한 쥐에서 수동피부과민반응을 유도하여 경구투여 했을 때 알러지성 과민반응...

Atopic dermatitis (AD) is a chronic, allergic, and inflammatory skin disease associated with eczema symptoms. Our previous studies have reported that eriodictyol extract inhibits immunoglobulin E (IgE)/Ag-induced type I hypersensitivity by suppressing the activation of proinflammatory cytokines, such as interleukin-4 (IL-4), expression ceramide kinase. In this study, we investigated inhibitory effect on 2,4-dinitrochlorobenzene (DNCB)-induced AD-like lesions in ICR mice. Treatment 2 mg/mL...

Mast cells are the principal effector involved in allergic response, through release of histamine. We investigated effect eriodictyol, derived from painted maple and yerba santa, on mast cell degranulation an response animal model. also its expression ceramide kinase (CERK) calcium-dependent degranulation, activation by multiple cytokines. Eriodictyol suppressed beta-hexosaminidase, a marker interleukin (IL)-4 mRNA. It inhibited CERK mRNA, reduced concentration antigen-stimulated cells,...

Nodakenin, derived from the roots of Angelica gigas Nakai, is an important natural resource and medicinal material with anti-allergic anti- inflammatory activities. We have previously shown that nodakenin inhibits IgE/Ag-induced degranulation in mast cells. In this study, we investigated inhibitory effect on 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD)- like skin lesions ICR mice. Scratching behavior, severity score, blood IgE level, thickness were improved DNCB-induced...

Abstract Background Loss of muscle mass is the most common complication end-stage liver disease and negatively affects outcomes for transplantation (LT) recipients. We aimed to determine prognostic value a fully automated three-dimensional (3D) volume estimation using deep learning algorithms on abdominal CT in patients who underwent (LT). Methods This retrospective study included 107 LT from 2014 2015. Serial scans, including pre-LT 1- 2-year follow-ups were performed. From learning-based...