A5067818633- Pancreatic and Hepatic Oncology Research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gallbladder and Bile Duct Disorders
- Pancreatitis Pathology and Treatment
- Cancer Genomics and Diagnostics
- Neuroendocrine Tumor Research Advances
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- Peptidase Inhibition and Analysis
- Advanced Proteomics Techniques and Applications
- Pediatric Hepatobiliary Diseases and Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Radiomics and Machine Learning in Medical Imaging
- Esophageal and GI Pathology
- Cancer Cells and Metastasis
- Gastrointestinal Tumor Research and Treatment
- Nutrition and Health in Aging
- Molecular Biology Techniques and Applications
- Viral-associated cancers and disorders
- Colorectal Cancer Screening and Detection
- Ferroptosis and cancer prognosis
- Lung Cancer Research Studies
- Cancer Research and Treatments
- Genetic factors in colorectal cancer
- Clusterin in disease pathology
Samsung Medical Center
2022-2025
Sungkyunkwan University
2022-2025
Seoul National University
2000-2023
Seoul National University Hospital
2015-2023
New Generation University College
2020-2023
Eastern Hepatobiliary Surgery Hospital
2023
Second Military Medical University
2023
Ulsan College
2019-2022
University of Ulsan
2019-2022
Asan Medical Center
2019-2022
Abstract Background In gallbladder cancer, stage T2 is subdivided by tumour location into lesions on the peritoneal side (T2a) or hepatic (T2b). For tumours (T2a), it has been suggested that liver resection may be omitted without compromising prognosis. However, data to validate this argument are lacking. This study aimed investigate prognostic value of in and clarify adequate extent surgical resection. Methods Clinical from patients who underwent surgery for cancer were collected 14...
The progression of intraductal papillary mucinous neoplasms (IPMNs) the pancreas to malignant disease is still poorly understood. Observational and surgical series have failed provide comprehensive information.To identify dynamic variables associated with development by combining pathological features data from preoperative repeated observations.The Crossover Multicentric Study included a retrospective cohort patients branch-duct IPMNs (BD IPMNs) enrolled in surveillance program January 1,...
We performed a prospective, multicenter, randomized controlled study to investigate the clinical outcomes, including postoperative pancreatic fistulas (POPF), after using TachoSil® patch in distal pancreatectomy (NCT01550406).Between June 2012 and September 2014, 101 patients at five centers were into Control (n = 53) TachoSil 48) groups. In all patients, pancreas was resected stapler with Endo-GIA™ staples. The wrapped around stump only group, not group.The patient characteristics, age...
Abstract Background Robot surgery is a new method that maintains advantages and overcomes disadvantages of conventional methods, even in pancreatic surgery. This study aimed to evaluate safety benefits robot‐assisted minimally invasive pancreaticoduodenectomy (robot PD ). Methods included 237 patients who underwent between 2015 2017. Demographics surgical outcomes were evaluated. Results Fifty‐one robot 186 open . group had younger age (60.7 vs. 65.4 years, P = 0.006) lower body mass index...
Laparoscopic surgery has been widely accepted as a feasible and safe treatment modality in many cancers of the gastrointestinal tract. However, most guidelines on gallbladder cancer (GBC) regard laparoscopic contraindication, even for early GBC. This study aims to evaluate compare recent surgical outcomes open T1(a,b) GBC determine optimal strategy T1 The enrolled 197 patients with histopathologically proven no history other who underwent from 2000 2014 at 3 major tertiary referral hospitals...
Novel biomarkers for early diagnosis of pancreatic cancer (PC) are necessary to improve prognosis. We aimed discover candidate by identifying compositional differences microbiome between patients with PC (n = 38) and healthy controls 52), using microbial extracellular vesicles (EVs) acquired from blood samples. Composition analysis was performed 16S rRNA gene bacteria-derived EVs. Statistically significant in compositions were used construct prediction models after propensity score matching...
Abstract Background Preoperative biliary drainage (PBD) is commonly performed in patients with bile duct cancer (BDC). However, data regarding the timing of pancreatoduodenectomy (PD) after PBD are insufficient. This study aimed to investigate optimal for surgically and oncologically safe PD PBD. Methods Data who underwent BDC between 2018 2020 were reviewed. Risk factor analysis was determine clinical associations surgical survival outcomes. Dose–response curves plotted indicate effect time...
Background: The incidence of portal vein/superior mesenteric vein (PV/SMV) resection during pancreatoduodenectomy is increasing in clinical practice. This study investigated the significance preoperative PV/SMV assessment and intraoperative their correlation with pathological results long-term survival outcomes. Methods: We analyzed 443 patients undergoing at a tertiary center from 2012 to 2017 based on resection. Subgroup analyses were performed involvement, resection, margin status....
There is no consensus on the optimal treatment of T1b gallbladder cancer (GBC) due to lack evidence and difficulty anatomy pathological standardization.A total 272 patients with GBC who underwent surgical resection at 14 centers specialized hepatobiliary-pancreatic surgeons pathologists in Korea, Japan, Chile, United States were studied. Clinical outcomes including disease-specific survival (DSS) rates according types surgery analyzed.After excluding patients, 237 qualifying consisted 90 men...
The 8th edition of the American Joint Committee on Cancer (AJCC) staging system for pancreatic neuroendocrine tumor (PNET) included several significant changes. We aim to evaluate this compared 7th AJCC and European Neuroendocrine Tumors Society (ENETS) system.We used Korean nationwide surgery database (2000-2014). Of 972 patients who had undergone PNET, excluding diagnosed with ENETS/World Health Organization 2010 grade 3 (G3), only 472 accurate stage were included.Poor discrimination in...
The introduction of FOLFIRINOX regimen greatly changed the treatment for advanced pancreatic cancers. However, detailed studies on clinical effects and factors affecting prognosis are insufficient. We performed this study to evaluate surgical resection in cancer.Three hundred thirty-seven patients with cancer who initially received FOLFIRINOX, from January 2011 December 2017, were retrospectively reviewed. Patients evaluated according National Comprehensive Cancer Network guideline,...
A single tumor marker has a low diagnostic value in pancreatic cancer. Combinations of multiple biomarkers and unique analysis algorithms can be applied to overcome these limitations. This study sought develop using biomarker panels validate their performance the diagnosis ductal adenocarcinoma (PDAC). We used blood samples from 180 PDAC patients 573 healthy controls. Candidate markers consisted 11 that are commonly expressed various cancers which have previously demonstrated increased...
Circulating tumor cells (CTCs) are useful biomarkers of many solid tumors, but infrequently detected in early stage pancreatic ductal adenocarcinomas (PDACs). The first drainage venous blood flow come to portal vein and pass through the liver, they finally go out for peripheral blood. We thought that comparing CTCs from could enable us understand clinical meaning each different site PDACs. Therefore, we aimed determine 1) whether be reliably identified stages (operable) PDACs, 2) if there...
Recent studies on perioperative fluid administration in patients undergoing pancreaticoduodenectomy (PD) have suggested that increased loads are associated with worse outcomes. The purpose of this study was to investigate the relationship between intraoperative (IOF) and postoperative pancreatic fistula (POPF), determine additional risk factors affecting PD.From 2005 2014, a total 182 various periampullary diseases after PD were reviewed retrospectively at Dongguk University Ilsan Hospital,...
Neoadjuvant treatment may provide improved survival outcomes for patients with borderline resectable pancreatic cancer (BRPC). The purpose of this study is to evaluate the clinical neoadjuvant and identify prognostic factors.Forty who met National Comprehensive Cancer Network definition BRPC received followed by surgery between 2007 2015 were evaluated. Prospectively collected clinicopathological analyzed retrospectively.The mean age was 61.7 years male-to-female ratio 1.8:1. Twenty-six, 3,...