A5084801741- Asthma and respiratory diseases
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Occupational exposure and asthma
- Respiratory and Cough-Related Research
- Drug-Induced Adverse Reactions
- Contact Dermatitis and Allergies
- Food Allergy and Anaphylaxis Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Lung Cancer Treatments and Mutations
- Respiratory Support and Mechanisms
- Lung Cancer Research Studies
- Indoor Air Quality and Microbial Exposure
- Autoimmune Bullous Skin Diseases
- Pediatric health and respiratory diseases
- Mast cells and histamine
- Dermatology and Skin Diseases
- Occupational and environmental lung diseases
- IL-33, ST2, and ILC Pathways
- Eosinophilic Esophagitis
- Neonatal Respiratory Health Research
- Lung Cancer Diagnosis and Treatment
- Tracheal and airway disorders
- Inhalation and Respiratory Drug Delivery
Korea University
2016-2025
Korea University Medical Center
2014-2024
University of California, San Diego
2019-2020
University of North Sumatra
2019
Yamaguchi University
2019
Creative Commons
2018
Inje University Haeundae Paik Hospital
2018
Ajou University
2007-2009
Ajou University Hospital
2007
Neutrophils are considered to play a central role in ventilator-induced lung injury (VILI). However, the pulmonary consequences of neutrophil accumulation have not been fully elucidated. Matrix metalloproteinase-9 (MMP-9) had postulated participate transmigration. The purpose this study was investigate MMP-9 neutrophilic inflammation VILI. Male Sprague-Dawley rats were divided into three groups: 1) low tidal volume (LVT), 7 ml/kg (VT); 2) high (HVT), 30 VT; and 3) HVT with MMP inhibitor...
Differences in definitions of the condition, relevant triggers, and geographical locations study centers, cause estimates prevalence anaphylaxis to vary. Recent epidemiological data indicate that incidence is rising.To investigate causes clinical features Korean adults, factors associated with severity serious outcomes, a retrospective medical record review was performed on adult patients diagnosed between 2007 2011 15 University Hospitals South Korea.A total 1,806 cases (52% male, age 16-86...
Harmful impact of air pollution on severe acute exacerbation chronic obstructive pulmonary disease: particulate matter is hazardous Juwhan Choi, Jee Youn Oh, Young Seok Lee, Kyung Hoon Min, Gyu Hur, Sung Yong Ho Kang, Jae Jeong Shim Division Respiratory, Allergy and Critical Care Medicine, Department Internal Korea University Guro Hospital, College Seoul, Republic Introduction: Particulate in are becoming worse. There a lack research regarding the patients with COPD. Therefore, purpose this...
Prostaglandin (PGE2), synthesized by cyclooxygenase-2 (COX-2), is associated with cellular immune tolerance during the process of cancer development. Induction requires a specific environment in which dendritic cells and regulatory T (Tregs) play an essential role. It was recently shown that maturation presence indoleamine 2, 3-dioxygenase (IDO) results activation Tregs, inhibition COX-2 activity regulated IDO expression within tumor microenvironment. Thus, we hypothesized would be inhibited...
The aim of this study was to evaluate the characteristics and prognostic factors small cell lung cancer (SCLC) with bone metastases. We also investigated predictive skeletal-related events (SREs) in these patients.Sixty-one patients who were first diagnosed SCLC metastases at our institution included retrospective analysis.The overall survival (OS) shorter than that without (4.13 vs. 6.17 months, p = 0.015). Poor Eastern Cooperative Oncology Group (ECOG) performance status (PS; ≥2) higher...
The optimal management of hospital-presenting sepsis remains poorly understood. We investigated the initial in patients presenting with general ward, association between fluid resuscitation and clinical outcomes, factors affecting resuscitation. A retrospective study was conducted on who presented sepsis-induced hypotension ward. Patients were divided into Less 30 (fluid less than mL/kg) More mL/kg or more) groups. Multivariable logistic regression analysis performed. median volume 500 mL...
Background The relationship between pre-treatment levels of blood eosinophil count (BEC), fractional exhaled nitric oxide (FeNO), and sputum eosinophils (Sp-EOS) treatment response to monoclonal antibodies (mAbs) in severe eosinophilic asthma (SEA) remain unclear. Objective We evaluated BEC, FeNO, Sp-EOS, their combinations as predictors responses patients with SEA undergoing anti-IL5/IL5Rα or anti-IL-4Rα antibody therapies. Methods study included 153 adult (59 94 anti-IL4Rα users). Logistic...
Eun Joo Leea, Kwang Ho Ina*, Sil Haa, Kyung Ju Gyu Young Hura, Hae Kanga, Ki Hwan Junga, Sung Yong Je Hyeong Kima, Sang Yeub Chol Shina, Jae Jeong Shima, Kanga & Se Hwa Yooaa Division of Respiratory and Critical Care Medicine, Department Internal Korea University College Seoul,
Anisakidae larvae can cause anisakiasis when ingested by humans. Although several groups have reported a gastrointestinal Anisakis allergy among people in Spain and Japan, our report is the first to summarize clinical features of 10 cases Korea. We enrolled Korean patients (6 men 4 women) who complained aggravated allergic symptoms after ingesting raw fish or seafood. Sensitization was confirmed detecting serum specific IgE simplex. The most common manifestation urticaria (100%), followed...
BackgroundA multidrug regimen including isoniazid, rifampicin, pyrazinamide and ethambutol is commonly used as first‐line treatment for tuberculosis. However, this can occasionally result in severe adverse drug reactions, such reaction with eosinophilia systemic symptoms (DRESS) syndrome drug‐induced liver injury. The culprit mechanistic basis the hypersensitive are unknown.
Abstract Purpose Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a rare but serious condition that systematically damages various internal organs through T‐cell–mediated immunological drug reactions. We aimed to investigate whether clinical manifestations of DRESS differ according culprit drugs. Methods retrospectively analyzed data from 123 patients probable/definite based on the RegiSCAR criteria (January 2011 July 2016). The were obtained Korean Severe Cutaneous...
Objectives: Leukotriene receptor antagonists (LTRA), such as montelukast, have been used a first-line treatment for patients with aspirin-intolerant asthma (AIA). This study evaluated associations between the clinical requirement LTRA and genetic polymorphisms of ALOX5, LTC4S, COX-2, CysLTR1 TBXA2R genes in arachidonic acid cascade long-term management 89 AIA from Korean population. Methods: Asthma control status was monitored 1 year maintenance medications inhaled corticosteroid oral LTRA,...
The EGFR plays an essential role in goblet cell hyperplasia and mucus hypersecretion. has intrinsic tyrosine kinase activity that, when activated, induces the production of MUC5AC through signaling cascade airway epithelium. We have investigated effects inhibitor, gefitinib, on ovalbumin (OVA)-induced, allergic inflammation epithelia mice. OVA-sensitized mice were pretreated with gefitinib at two different doses (12.5 50 mg/kg) then challenged OVA. OVA challenge increased total count...
The main etiologic factor for chronic bronchitis is cigarette smoke. Exposure to smoke reported induce goblet cell hyperplasia and mucus production. Mucin synthesis in airways has been be regulated by the EGFR system. Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) a member of ligand-activated nuclear receptor superfamily. PPAR-gamma implicated anti-inflammatory responses, but mechanisms underlying these varied roles remain ill-defined. Recently, reports have shown that...
Histamine plays an important role in allergic inflammation. levels are regulated by histamine N-methyltransferase (HNMT).To investigate the functional variability of HNMT gene relation to genetic polymorphisms patients with aspirin intolerant chronic urticaria (AICU).Two single-nucleotide (314C>T, 939A>G) were genotyped patients. The 3'-untranslated region polymorphism (3'-UTR) was assessed using pEGFP-HNMT 3'-UTR reporter construct examine mRNA stability and fluorescence-tagged protein...
Chronic obstructive pulmonary disease (COPD) is associated with systemic inflammation.To evaluate carotid artery intima-media thickness (IMT), high sensitivity C-reactive protein (hsCRP) and their correlation in newly diagnosed untreated patients COPD.Post-bronchodilator spirometry, IMT blood tests were measured COPD (COPD group). Age, sex, body mass index, smoking status amount compared matched healthy subjects (non-COPD Participants taking medications and/or a history of hypertension,...