A5008706533- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Urticaria and Related Conditions
- Allergic Rhinitis and Sensitization
- Drug-Induced Adverse Reactions
- Food Allergy and Anaphylaxis Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Dermatology and Skin Diseases
- Mast cells and histamine
- Inhalation and Respiratory Drug Delivery
- Autoimmune Bullous Skin Diseases
- IL-33, ST2, and ILC Pathways
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Immunodeficiency and Autoimmune Disorders
- Contact Dermatitis and Allergies
- Occupational exposure and asthma
- Sphingolipid Metabolism and Signaling
- Inflammatory mediators and NSAID effects
- Eosinophilic Esophagitis
- Cystic Fibrosis Research Advances
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Cancer Risks and Factors
- Neonatal Respiratory Health Research
- Indoor Air Quality and Microbial Exposure
- Immune Cell Function and Interaction
Kangdong Sacred Heart Hospital
2018-2024
Hallym University
2018-2024
Ajou University
2012-2020
Ajou University Hospital
2015-2018
Suwon Research Institute
2016
Zero to Three
2016
Medical University of Vienna
2012-2013
Comprehensive Cancer Center Vienna
2013
GfK (United States)
2012
Dankook University
2008
Summary Background Autophagy and neutrophil extracellular DNA traps ( NET s) are implicated in asthma; however, their roles asthma pathogenesis have not been elucidated. Objectives We compared autophagy production levels from peripheral blood neutrophils PBN of patients with severe SA ) non‐severe NSA ). Additionally, we investigated the inflammatory effects s on human airway epithelial cells AEC eosinophils PBE s). Methods Peripheral n = 30) 38) were treated interleukin IL )‐8 (100 ng/mL)....
Autophagy and genetic predisposition have been suggested to potentially play roles in the development of asthma. However, little is known about role autophagy pathogenesis severe asthma.We compared sputum granulocytes, peripheral blood cells (PBCs) eosinophils (PBEs) between patients with asthma those non-severe investigated functional effects autophagy.We enrolled 36 asthma, 14 23 normal healthy controls this study. Sputum PBCs PBEs were isolated from each subject. was evaluated based on...
Increasing evidence suggests that adipokines affect immune responses and chronic urticaria (CU) is associated with an altered response related to systemic inflammation. Our objectives were investigate whether are involved in CU pathogenesis outline relationships between severity quality of life.Serum adiponectin, leptin, lipocalin-2 (LCN2), interleukin (IL)-10, IL-6, tumor necrosis factor (TNF)-α concentrations measured by enzyme-linked immunosorbent assays 191 patients 89 healthy controls....
Purpose: Chronic urticaria (CU) has a substantial impact on the quality of life.Little clinical data prognosis CU been reported.This study aimed to investigate control status and remission rate explore potential predictors good responses treatment during 6-month period.Methods: A total 75 patients with chronic spontaneous (CSU) were enrolled from 3 university hospitals in Korea.Urticaria state was classified into 2 groups: group I (remission well-controlled) II (partly...
Purpose: Although mild to moderate asthma is much more common, the morbidity and mortality of severe are higher.This study was performed identify analyze clinical characteristics in Korea.Methods: We registered patients with refractory into Severe Asthma Registry supported by Work Group Korean Academy Asthma, Allergy Clinical Immunology.Patients were enrolled since 2010 from 15 university hospitals nationwide Korea.Severe defined according modified European Respiratory Society/American...
Abstract Background Asthma is associated with inflammatory dysregulation, but the underlying metabolic signatures are unclear. This study aimed to classify asthma phenotypes based on cellular and features. Methods To determine profiles, we assessed cell markers using flow cytometry, sphingolipid (SL) metabolites LC‐MS/MS, serum cytokines ELISA. Targeted gene polymorphisms were determined identify genetic predispositions related phenotype. Results In total, 137 patients 20 healthy controls...
Severe asthma is associated with high morbidity and healthcare utilization; however, treatment options for these patients are limited. This study aimed to determine the therapeutic effects of biologics in clinical practice. multicenter, retrospective cohort included 136 who received at least 4 months between September 2017 July 2022 25 medical centers affiliated Korean Asthma Registry (KoSAR). The evaluated effects, including acute exacerbation rates, maintenance oral corticosteroid dosages,...
Chronic urticaria (CU) is a common skin disorder characterized by wheals and pruritus lasting more than 6 weeks. Due to its long duration changeable symptoms, the quality of life (QOL) patients with CU can be impaired substantially. We evaluated CU-QOL, previously validated CU-specific QOL measure, investigated factors influencing in chronic spontaneous (CSU) patients.A hospital-based cross-sectional study was performed on 390 adult diagnosed CSU from March 2009 December 2012 at Allergy...
BackgroundA multidrug regimen including isoniazid, rifampicin, pyrazinamide and ethambutol is commonly used as first‐line treatment for tuberculosis. However, this can occasionally result in severe adverse drug reactions, such reaction with eosinophilia systemic symptoms (DRESS) syndrome drug‐induced liver injury. The culprit mechanistic basis the hypersensitive are unknown.
To date, there has been no reliable in vitro test to diagnose aspirin-exacerbated respiratory disease (AERD).To investigate potential diagnostic biomarkers for AERD using metabolomic analysis.An untargeted profile of serum from asthmatics the first cohort (group 1) comprising 45 AERD, 44 patients with aspirin-tolerant asthma (ATA), and 28 normal controls was developed ultra-high-performance liquid chromatography (UHPLC)/Q-ToF MS system. Metabolites that discriminate ATA were quantified both...
Clinical presentation of nonsteroidal anti-inflammatory drugs exacerbated respiratory disease (NERD) is found to be heterogeneous. This study classified phenotypic clusters determine NERD subtypes.We performed two-step cluster analysis using urticaria, chronic rhinosinusitis (CRS), and atopy, in a cohort comprising 302 patients. Asthma exacerbation was defined as receiving at least one burst intravenous steroid treatment and/or two bursts oral use (≥ 45 mg/3 days) per year. The possession...
Abstract Sphingolipid (SL) metabolites have been suggested to be important inflammatory mediators in airway inflammation and asthma. However, little is known about SL aspirin-exacerbated respiratory disease (AERD). We aimed explore the potential AERD biomarkers by conducting lipidomics targeting metabolites. The levels of serum urine samples from 45 patients aspirin-tolerant asthma (ATA) were quantified through mass spectrometry. During lysine-aspirin bronchoprovocation test (ASA-BPT),...
Background: Asthma is a chronic inflammatory airway disease characterized by the predominant infiltration of cells in airways. Thymus and activation-regulated chemokine/C–C motif chemokine 17 (TARC/CCL17) responsible for trafficking T helper 2 into sites allergic inflammation. Objective: To validate role TARC association with clinical parameters adult asthmatics. Methods: We enrolled 128 asthmatic patients 70 healthy controls (HCs). Asthma-related laboratory parameters, including lung...
BackgroundAlthough 8-iso-prostaglandin F2a has been proposed as a potential biomarker for oxidative stress in airway diseases, its specific role asthma remains poorly understood.ObjectiveTo evaluate the diagnostic of assessing inflammation, remodeling, hyperresponsiveness, and asthma.MethodsBlood urine concentrations were quantified using liquid chromatography-tandem mass spectrometry 128 adults with who had maintained anti-asthmatic medications. Their correlations clinical data, sputum cell...
Both immediate and delayed hypersensitivity reactions to iodinated contrast media (ICM) are relatively common. However, there few data determine the clinical utility of immunologic evaluation ICM. To evaluate ICM skin testing in patients with hypersensitivity, 23 (17 6 reactions) were enrolled from 3 university hospitals Korea. With commonly used including iopromide, iohexol, ioversol, iomeprol, iopamidol iodixanol, prick (SPT), intradermal (IDT) patch tests performed. Of 10 anaphylaxis,...
The hypothesis of autoimmune involvement in asthma has received much recent interest. Autoantibodies, such as anti-cytokeratin (CK) 18, anti-CK19, and anti- α -enolase antibodies, react with self-antigens are found at high levels the sera patients severe (SA). However, mechanisms underlying autoantibody production SA have not been fully determined. present study was conducted to demonstrate that neutrophil extracellular DNA traps (NETs), cytotoxic molecules released from neutrophils, a key...
Purpose: House dust mites (HDM) are major allergens that cause allergic rhinitis (AR).Allergen-specific subcutaneous immunotherapy (SCIT) has been shown to be clinically beneficial in many clinical trials.Such trials, however, not reflective of all patient populations.The aim this study was describe the efficacy and safety SCIT routine practice Korean adults with AR sensitized HDM.Methods: We reviewed medical records 304 patients treated at an allergy clinic a tertiary hospital using...
Chronic spontaneous urticaria (CSU) is a common skin disorder characterized by itchy wheals of at least 6 weeks in duration, wherein the autoimmune mechanism involved to activate IgE receptors (FcεRIα) on mast cells. We aimed assess levels IgG autoantibody against FcεRIα sera from CSU patients using dot-blot immunoassay. performed hospital-based cross-sectional study 125 (64 ASST-positive, 61 ASST-negative) and 64 age-and sex-matched healthy controls. The cut-off value was determined as mean...
Abstract Background While the clinical characteristics and outcomes of asthma‐chronic obstructive pulmonary disease (COPD) overlap (ACO) have been frequently compared with those COPD or asthma, prevalence features ACO in patients severe asthma are unclear. Objectives Evaluation using Korean registry. Methods At time registration, was determined by attending specialists. Patients were classified into non‐ACO groups, demographic these two groups compared. Results Of 482 23.7% had ACO. group...
Background/Aims Chronic urticaria (CU) is defined as itchy wheals lasting 6 weeks or more. As the aged population increases worldwide, it essential to identify specific features of this disease in elderly population. Methods We investigated prevalence and clinical CU patients. Medical records 837 patients from outpatient Allergy Clinic Ajou University Hospital, Korea were analyzed retrospectively. Patients with chronic spontaneous according EAACI/GA2LEN/EDF/WAO guidelines included. older...