A5100429215- Nanoplatforms for cancer theranostics
- Total Knee Arthroplasty Outcomes
- Nanoparticle-Based Drug Delivery
- Asthma and respiratory diseases
- Voice and Speech Disorders
- Photodynamic Therapy Research Studies
- Thyroid and Parathyroid Surgery
- Head and Neck Cancer Studies
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Head and Neck Anomalies
- Internet of Things and Social Network Interactions
- Monoclonal and Polyclonal Antibodies Research
- Antenna Design and Analysis
- Cancer-related molecular mechanisms research
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Eosinophilic Esophagitis
- Spinal Hematomas and Complications
- Eosinophilic Disorders and Syndromes
- Cardiac Arrhythmias and Treatments
- Electrospun Nanofibers in Biomedical Applications
- Neurological and metabolic disorders
- Dendrimers and Hyperbranched Polymers
- Tracheal and airway disorders
Catholic University of Korea
2008-2025
Chungnam National University
2024
Gyeongsang National University
2023
Ajou University
2017-2023
Hallym University Kangnam Sacred Heart Hospital
2023
Changwon National University
2023
Chonnam National University Hospital
2017-2019
Chonnam National University Hwasun Hospital
2017-2018
SickKids Foundation
2018
University of Toronto
2018
Background: Descriptive epidemiologists have repeatedly reported that males are more susceptible to head and neck cancers. However, most published data those of cross-sectional studies, no population-based cohort study has yet been published. The aim this was compare the prevalence cancers in healthy with females. Methods: A retrospective using Korean National Health Insurance Service database on 9,598,085 individuals who underwent regular health checkups from 1 January 31 December 2009. We...
Abstract Background Activated eosinophils release extracellular traps (EETs), which contribute to airway inflammation in severe asthma (SA). However, the role of EETs innate immunity has not yet been completely determined. The present study aimed demonstrate mechanism SA mediated by EETs. Methods Peripheral counts EET + and type 2 lymphoid cells (ILC2s) were evaluated patients with (n = 13), nonsevere (NSA, n 17), healthy control subjects (HC, 8). To confirm effect EETs, hyperresponsiveness...
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Abstract An ideal hydrogel for stem cell therapy would be injectable and efficiently promote proliferation differentiation in body. Herein, an injectable, single‐component with hyaluronic acid (HA) modified phenylboronic (PBA) spermidine (SM) is introduced. The resulting HAps (HA‐PBA‐SM) based on the reversible crosslinking between diol ionized PBA, which stabilized by SM. It has a shear‐thinning property, enabling its injection through syringe to form stable inside In addition, undergoes...
In combination therapy, synergetic effects of drugs and their efficient delivery are essential. Herein, we screened 12 anticancer for with photodynamic therapy (PDT) using pheophorbide a (Pba). On the basis index (CI) values in cell viability tests, selected tirapazamine (TPZ) developed self-assembled gelatin nanoparticles (NPs) containing both Pba TPZ. The resulting TPZ-Pba-NPs showed effect to kill tumor cells because TPZ was activated under hypoxic conditions that originated from PDT...
Combination therapy using more than one drug can result in a synergetic effect clinical treatment of cancer. For this, it is important to develop an efficient delivery system that contain multiple drugs and provide high accumulation tumor tissue. In particular, simultaneous stable loading with different chemical properties into single nanoparticle carrier difficult problem.We developed rhamnolipid-coated double emulsion nanoparticles containing doxorubicin erlotinib (RL-NP-DOX-ERL) for...
Abstract Bacterial extracellular vesicles (EVs) have been shown to regulate various pulmonary diseases, but their functions in asthma remain uncertain. To demonstrate the clinical significance of Micrococcus luteus -derived EVs (MlEVs) asthma, we enrolled 45 asthmatic patients (20 with neutrophilic [NA], 25 eosinophilic [EA]) and 40 healthy controls (HCs). When prevalence IgG1 IgG4 specific MlEVs was evaluated serum by ELISA, lower levels MlEV-specific (but not IgG1) were noted than HCs....
The treatment of laryngeal cancer requires clinical decision-making that balances survival outcomes with the preservation essential functions such as voice and swallowing. study, led by Clinical Practice Guideline Committee Korean Society Head Neck Surgery, aims to establish evidence-based recommendations guide optimal decisions for patients from surgeons' perspectives. A literature search was conducted in PubMed, Embase, Cochrane Library, KoreaMed databases a expert reviewed panel 39...
Acute airway obstruction (AAO) after anterior cervical fusion (ACF) can be caused by postoperative retropharyngeal hematoma, which requires urgent recognition and treatment. However, the causes, evaluation, appropriate treatment of this complication are not clearly defined. The purpose retrospective review a prospective database was to investigate etiologic factors related development AAO due hematoma ACF formulate prevention guidelines. Cervical spinal cases treated at our academic...
With the rate of worldwide LNG demand expected to grow faster than that gas demand, most major oil companies are currently investing their resources develop floating LNG-FLNG (i.e. FSRU and FPSO). The global Floating (FLNG) market trend will be reviewed based on supply chain relationships. Typical technical issues associated with FLNG design categorized in terms performance evaluation. Although many proven technologies developed through carrier FPSO projects available for design, we still...
The aim of this study was to develop evidence-based recommendations for determining the surgical extent in patients with locally invasive differentiated thyroid cancer (DTC). Locally DTC gross extrathyroidal extension invading surrounding anatomical structures may lead several functional deficits and poor oncological outcomes. At present, optimal surgery remains a matter debate, there are no adequate guidelines. On October 8, 2021, four experts searched PubMed, Embase, Cochrane Library...
Background: Asthma is a chronic inflammatory airway disease characterized by the predominant infiltration of cells in airways. Thymus and activation-regulated chemokine/C–C motif chemokine 17 (TARC/CCL17) responsible for trafficking T helper 2 into sites allergic inflammation. Objective: To validate role TARC association with clinical parameters adult asthmatics. Methods: We enrolled 128 asthmatic patients 70 healthy controls (HCs). Asthma-related laboratory parameters, including lung...
Introduction. Mucosal margins exhibit a mean shrinkage of 30–40% after resection oral and oropharyngeal cancers, an adequate in situ surgical margin frequently results pathological close margin. However, the impact on prognosis remains unclear. We investigated disease-free survival (DFS) overall (OS). Methods. retrospectively reviewed clinicopathological data 418 patients diagnosed with squamous cell carcinomas cavity or oropharynx who underwent initial surgery (with curative intent) at our...
Abstract Background Rheumatoid arthritis (RA) is a progressive systemic autoimmune disease that characterized by infiltration of inflammatory cells into the hyperplastic synovial tissue, resulting in subsequent destruction adjacent articular cartilage and bone. Methotrexate (MTX), first conventional disease-modifying antirheumatic drug (DMARD), could alleviate damage RA implicated humoral cellular immune responses. However, MTX has several side effects, so efficient delivery low-dose...
The hypothesis of autoimmune involvement in asthma has received much recent interest. Autoantibodies, such as anti-cytokeratin (CK) 18, anti-CK19, and anti- α -enolase antibodies, react with self-antigens are found at high levels the sera patients severe (SA). However, mechanisms underlying autoantibody production SA have not been fully determined. present study was conducted to demonstrate that neutrophil extracellular DNA traps (NETs), cytotoxic molecules released from neutrophils, a key...
We fabricated poly (ethylene glycol)-block-polycaprolactone (PEG-b-PCL) nanoemulsion for drug delivery and photodynamic therapy. PEG-b-PCL effectively stabilized the interface between water soybean oil, resulting was about 220.3 nm in diameter with spherical shape. For therapy (PDT), chlorin e6 (Ce6) loaded into as a photosensitizer (PS). These e6-loaded PEG-PCL nanoemulsions (Ce6-PCL-NEs) showed efficient cellular uptake and, upon laser irradiation, generated singlet oxygen to kill tumor...
Ferrocene-based nanoparticles have garnered interest as reactive oxygen species (ROS)-responsive nanocarriers of anticancer drugs and imaging agents. However, their biomedical applications remain limited due to poor physiological stability. PEGylation improves stability biocompatibility. In this study, we aimed develop novel PEG-ferrocene (PFNPs) with enhanced ROS responsiveness for the delivery paclitaxel (PTX) improved ferrocene nanoparticles, inhibiting ROS-responsive destruction. Several...
Patients with cervical myelopathy may experience symptoms of radiculopathy, and it is not easy to determine whether these are caused by the itself or a radiculopathy accompanied root compression. Therefore, we aimed investigate prevalence combined evaluate characteristics without radiculopathy. We enrolled 127 patients in this retrospective study reviewed their medical records magnetic resonance imaging findings. They were divided into two groups according presence age, sex, involved spinal...