A5085524029- Vascular Malformations and Hemangiomas
- Thyroid Cancer Diagnosis and Treatment
- Ear and Head Tumors
- Tracheal and airway disorders
- Thyroid and Parathyroid Surgery
- Head and Neck Anomalies
- Vestibular and auditory disorders
- Voice and Speech Disorders
- Airway Management and Intubation Techniques
- Immune cells in cancer
- Soft tissue tumor case studies
- Sphingolipid Metabolism and Signaling
- Hearing, Cochlea, Tinnitus, Genetics
- Salivary Gland Tumors Diagnosis and Treatment
- Vascular Anomalies and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Esophageal and GI Pathology
- Biliary and Gastrointestinal Fistulas
- Quality and Supply Management
- Soft tissue tumors and treatment
- Cancer and Skin Lesions
- Ear Surgery and Otitis Media
- Education, Safety, and Science Studies
- Ophthalmology and Eye Disorders
- Cardiac, Anesthesia and Surgical Outcomes
Hallym University Dongtan Sacred Heart Hospital
2022-2025
Hallym University
2023-2024
Seoul National University Bundang Hospital
2016-2022
Seoul National University
2016-2022
Boramae Medical Center
2016-2022
Seoul National University Hospital
2015-2021
Kyungpook National University
2018-2020
Seoul Metropolitan Government
2016
Hanyang University Guri Hospital
2009
Catholic University of Korea
1993-2008
Although many reports have revealed the importance of defective microglia-mediated amyloid β phagocytosis in Alzheimer's disease (AD), underlying mechanism remains to be explored. Here we demonstrate that neurons brains patients with AD and mice show reduction sphingosine kinase1 (SphK1), leading microglial dysfunction inflammation resolution due decreased secretion specialized proresolving mediators (SPMs). Elevation SphK1 increased SPMs secretion, especially 15-R-Lipoxin A4, by promoting...
Abstract Sphingosine kinase1 (SphK1) is an acetyl-CoA dependent acetyltransferase which acts on cyclooxygenase2 (COX2) in neurons a model of Alzheimer’s disease (AD). However, the mechanism underlying this activity was unexplored. Here we show that N-acetyl sphingosine (N-AS) first generated by and through SphK1. N-AS then acetylates serine 565 (S565) COX2, N-AS-acetylated COX2 induces production specialized pro-resolving mediators (SPMs). In mouse AD, microglia reduction generation, leading...
The treatment of laryngeal cancer requires clinical decision-making that balances survival outcomes with the preservation essential functions such as voice and swallowing. study, led by Clinical Practice Guideline Committee Korean Society Head Neck Surgery, aims to establish evidence-based recommendations guide optimal decisions for patients from surgeons' perspectives. A literature search was conducted in PubMed, Embase, Cochrane Library, KoreaMed databases a expert reviewed panel 39...
Abstract Background To determine the efficacy of preoperative Comprehensive Geriatric Assessment (CGA) in predicting postoperative complications elderly patients undergoing head and neck cancer surgery. Methods Medical records aged ≥70 who underwent elective surgery were reviewed. CGA scores prospectively collected prior to analyzed their association with complications. Results Of 65 enrolled this study, 34 (52.3%) deficits two or more domains categorized as “frail.” Fourteen (21.5%)...
Jang SH, Lee H, Han SH: Common peroneal nerve compression by a popliteal venous aneurysm. Am J Phys Med Rehabil 2009;88:947–950. A 58-yr-old man with right foot drop and sensory change in the calf foot, which developed after bladder operation, was referred to our clinic for an electrodiagnostic evaluation. Neurologic examination showed grade 1 weakness of ankle dorsiflexion, great toe eversion. In addition, patient complained pain tingling sensation foot. Electrodiagnostic findings were...
Owing to the functional and structural complexity of head neck area, reconstruction defects in these areas is challenging. Free flap surgery has become standard for with improvements microvascular surgery. The aim this study was use cumulative sum (CUSUM) method evaluate learning curve free-flap performed by a single surgeon.We retrospectively reviewed medical records 47 patients who underwent from 2017 2021. clinical demographics surgical outcomes were analyzed. total operation time...
Background: The ear is a common site for keloid formation, typically due to piercing or trauma. Auricular keloids are always difficult treat and pose challenging situation. purpose of this study present our experience treating earlobe through complete surgical excision followed by immediate postoperative single fraction 10 Gy radiation therapy either on the same day next day. Methods: authors retrospectively evaluated 48 patients with 71 treated single‐fractional radiotherapy within 24 hours...
This study aimed to compare the oncological outcomes of partial versus superficial or total parotidectomy for T1 T2 primary parotid cancers and investigate their prognostic factors recurrence patterns. The medical records 77 patients with T1-2 malignancies between May 2003 March 2022 were retrospectively reviewed. Univariate multivariate analyses performed evaluate associated overall survival, disease-free local distant recurrence. average follow-up duration was 70.2 months (range, 12-202...
Remote-access robotic thyroid surgery enables avoiding a visible scar on the neck and allows precise manipulation through magnified surgical view. The retroauricular approach has many advantages. This study aimed to evaluate learning curve for thyroidectomy using cumulative sum analysis.The medical records of 36 patients who underwent between 2018 2021 were retrospectively reviewed. clinical features outcomes analyzed; was evaluated analysis divided into two phases based 15 cases: phase I...
Subglottic cysts (SGCs) are a rare cause of respiratory distress resulting from upper airway obstruction in infants and young children. Risk factors other than prematurity with history endotracheal intubation have not yet been well elucidated. Therefore, we aimed to describe the clinical features analyze risk SGCs.We conducted retrospective review medical records pediatric patients who underwent marsupialization for SGCs between January 2017 March 2022. These were then compared those...
Abstract Objective This study aimed to analyze the usefulness of an additional axillary port in robotic retroauricular thyroidectomy by comparing perioperative data and postoperative function between operations with without port. Materials methods A retrospective review medical records 11 patients who underwent thyroid using a unilateral approach or 2016 2021 was conducted. Patient demographics, operation time, drainage amount, hospital stay, complication, cosmetic satisfaction, neck...
Thyroid surgery, characterized by its high risk due to the vascular nature of thyroid gland, often leads significant postoperative bleeding. This study assesses efficacy using drains prevent complications such as hematomas, seromas, and bleeding, their impact on infection rates hospitalization duration post-thyroidectomy. Following PRISMA guidelines, a systematic search was conducted across PubMed, Embase, Cochrane Library, including randomized controlled trials published prospective studies...
Vocal fold injection (VFI) via the cricothyroid (CT) membrane is used to treat various diseases affecting vocal folds. The technical challenges of this technique are mainly related invisibility needle. Real-time light-guided VFI (RL-VFI) was recently developed for under simultaneous light guidance in CT approach. Herein, we present first clinical trial RL-VFI, which investigated feasibility and safety new unilateral paralysis (VFP). This prospective pilot study enrolled 40 patients, who were...
Received June 1, 2015 Revised July 27, Accepted Address for correspondence Myung-Whan Suh, MD, PhD Department of OtorhinolaryngologyHead and Neck Surgery, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, 03080, Korea Tel +82-2-2072-2448 Fax +82-2-2072-2447 E-mail drmung@naver.com Background ObjectivesZZThere exist few studies about relationship between tinnitus sleep disturbance. Furthermore, the currently available have some limitations confounding factors. This study evaluated...
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Background and Objectives Tracheostomy lead to persistent bacterial colonization of the respiratory tract. Surgical site infection restenosis by pathogenic bacteria is most fatal complication after open airway surgery. The aim this study describe culture results larynx tracheostoma in patients with tracheostomy preoperative, intraoperative underwent Materials Method A retrospective review was performed on 18 who between 2017 2019. Results Pseudomonas or antibiotic resistance were identified...
Venous malformation with phleboliths is uncommon cause of unilateral parotid swelling. The clinical and radio-graphic appearance venous may masquerade as sialolithiasis. A 49-year-old female complained about swelling for 6 years. Preoperative evaluation including computed tomography sonography showed the suspicion phleboliths. Superficial parotidectomy was performed. Pathological examination confirmed that mass combined sialolith in gland. We present case caused by a malforma-tion
Backgrounds: Atorvastatin which has a highly variable pharmacokinetic profileoften shows double peaks.However, in most cases it been regarded as noise or assay error.In this study we compared 4 different absorption models (zero order, 1 st combined and parallel model) to determine model best describes the process.Methods: Plasma atorvastatin data of 57 healthy subjects from two bioequivalence studies were used.Concentrations measured up 48 hours after drug administration.Mixed effect...