A5026322975- Pharmacogenetics and Drug Metabolism
- Statistical Methods in Clinical Trials
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Methods in Pharmaceuticals
- Pharmaceutical studies and practices
- Drug Transport and Resistance Mechanisms
- Pharmacological Effects and Toxicity Studies
- Cancer Treatment and Pharmacology
- Bacterial Identification and Susceptibility Testing
- Cardiac electrophysiology and arrhythmias
- Cancer therapeutics and mechanisms
- Cancer, Hypoxia, and Metabolism
- Health Systems, Economic Evaluations, Quality of Life
- Antimicrobial Resistance in Staphylococcus
- Pharmaceutical Economics and Policy
- Lipoproteins and Cardiovascular Health
- Meta-analysis and systematic reviews
- Antibiotic Resistance in Bacteria
- Biosimilars and Bioanalytical Methods
- Analytical Chemistry and Chromatography
- Cancer-related Molecular Pathways
- Monoclonal and Polyclonal Antibodies Research
- Advanced Drug Delivery Systems
- Antifungal resistance and susceptibility
- Pneumocystis jirovecii pneumonia detection and treatment
Seoul St. Mary's Hospital
2013-2022
Catholic University of Korea
2013-2022
Seoul National University Hospital
1994-2018
Korea Research Institute for Vocational Education and Training
2017
Chungnam National University
2017
St. Mary’s Hospital
2015
Center for Drug Evaluation and Research
2008
Sir Charles Gairdner Hospital
2006
University of Pittsburgh
2006
Georgetown University
2004-2005
Docetaxel is widely used as a chemotherapeutic agent for gastric cancer treatment. A combined regimen with sunitinib demonstrated synergistic antitumour effect in preclinical model. The aim of this study was to evaluate the efficacy and safety combination patients unresectable or metastatic advanced following failure treatment fluoropyrimidine platinum combination. This open-label, phase II, randomised trial enrolled cancer. Patients were assigned either docetaxel monotherapy arm (D only...
Preclinical models suggest anticancer activity of IM156, a novel biguanide mitochondrial protein complex 1 inhibitor oxidative phosphorylation (OXPHOS). This first-in-human dose-escalation study enrolled patients with refractory advanced solid tumors to determine the maximum tolerated dose (MTD) or recommended phase 2 (RP2D). Eligible received oral IM156 every other day (QOD) daily (QD) and were assessed for safety, dose-limiting toxicities (DLTs), pharmacokinetics, preliminary signals...
A case–control study was performed to assess the potential influence of catechol O-methyl transferase (COMT) genotype on risk breast cancer in Korean women. One hundred and sixty-three histologically confirmed incident cases 163 age- menopausal status-matched control individuals with no present or previous history were selected as subjects. COMT genetic polymorphism determined by gel electrophoresis after Nla III enzyme digestion amplified DNA. Odds ratios 95% confidence intervals estimated...
BackgroundVoriconazole is a triazole agent with excellent antifungal activity against Aspergillus species. However, despite its potential advantages, the occurrence of unpredictable toxicities might be critical in immunocompromised patients. The aim this study was to analyze risk factors for voriconazole-related severe adverse events (SAEs).MethodsThis prospective observational conducted Korean patients hematological malignancies and invasive aspergillosis on intravenous voriconazole therapy...
Objective: The primary objective of this study was to combine an integrated microphysiological system (MPS) with a computational multicompartmental physiologically-based pharmacokinetic (PBPK) model improve methods for predicting human pharmacokinetics using diclofenac. We also tried identify transcriptomic biomarkers that respond significantly diclofenac exposure in MPS chip determine the similarity drug responses those and potential our understanding pharmacodynamics drugs.Methods: used...
This study was performed to estimate the population pharmacokinetic (PK) parameters of etanercept in pediatric juvenile rheumatoid arthritis (JRA) patients and compare steady‐state time‐concentration profiles between 0.8‐mg/kg once‐weekly 0.4‐mg/kg twice‐weekly subcutaneous (SC) regimens by clinical trial simulation. To this end, mixed‐effect analysis (NONMEM, Version 5.1) using PK database consisting 69 JRA (4–17 years). Based on obtained herein, a Monte Carlo simulation experiment...
The End-of-Phase 2A meetings are proposed to identify opportunities make innovative medical products available sooner and increase the quality of drug applications through early between sponsors FDA. This article summarizes overall experience across 11 pilot since 2004. Four case studies presented in more detail demonstrate various issues methods encountered at these meetings. Overall, industry FDA scientists ranked be "very helpful" (average score 4 on a scale 1 5). In almost all instances...
To develop a population pharmacokinetic model of meropenem in burn patients and to explore the appropriateness current dosage regimens. Fifty-nine with burns ranging from 3% 97% total body surface area treated were analysed. The parameters 59 estimated, concentrations simulated by using mixed effect method (NONMEM, ver. 6.2). final was two-compartment first-order elimination where creatinine clearance (CLCR) oedema contributed. mean (L/h) = 4.45 + 10.5 × CLCR (mL/min)/138, V1 (central...
Simvastatin (SV), a HMG-CoA reductase inhibitor, is widely used for the treatment of hyperlipidaemia. The objectives present study were to develop population pharmacokinetic-pharmacodynamic (PK-PD) model simvastatin and evaluate its usefulness in predicting dose-response relationship patients with data obtained from drug-drug interaction assess effect aspirin on PK simvastatin. Twenty-seven healthy volunteers given 40 mg daily 14 days whom 100 q.d. was co-administered after day 8. Full...
Summary Because of concerns about accumulation cyclodextrin, oral voriconazole is recommended for patients with renal impairment. However, intravenous may occasionally be imperative in critically ill life‐threatening invasive aspergillosis. We investigated the clinical effects formulated sulfobutylether β‐cyclodextrin ( SBECD ) A prospective observational study was conducted on 25 adult haematological malignancies who were treated Among them, seven had a baseline creatinine clearance (CrCl)...
This report focuses on the adaptive phase I trial design aimed to find clinically applicable dose for decitabine maintenance treatment after allogeneic hematopoietic stem cell transplantation in patients with higher-risk myelodysplastic syndrome and secondary acute myeloid leukemia. The first cohort (three patients) was given same initial daily of (5 mg/m2/day, five consecutive days 4-week intervals). In all cohorts, doses Cycles 2 4 were individualized using pharmacokinetic-pharmacodynamic...
Aims The pharmacokinetics of omeprazole and its metabolites in healthy subjects were evaluated to determine if a single dose moclobemide inhibited CYP2C19 activity. Methods Sixteen volunteers, whom eight extensive metabolizers (EM) poor for CYP2C19, participated two studies. Venous blood samples collected 24 h after oral ingestion 40 mg with or without 300 coadministration. pharmacokinetic change omeprazole, sulphone 5‐hydroxyomeprazole concentrations assessed test an interaction between...
Colistin is increasingly used as a salvage therapy for nosocomial infections caused by multidrug-resistant Gram-negative bacteria such Pseudomonas aeruginosa and Acinetobacter baumannii. However, the available pharmacokinetic (PK) data colistin are limited to guide dosing. The aim of this study was develop population PK model identify optimal dosage regimens burn patients. Fifty patients with burns ranging from 4% 85% total body surface area who had been treated colistimethate sodium (CMS)...
ABSTRACT Piperacillin in combination with tazobactam, a β-lactamase inhibitor, is commonly used intravenous antibiotic for the empirical treatment of infection intensive care patients, including burn patients. The purpose this study was to develop population pharmacokinetic (PK) model piperacillin patients and predict probability target attainment (PTA) using MICs concentrations simulated from PK model. Fifty treated piperacillin-tazobactam were enrolled. Piperacillin-tazobactam administered...
This tutorial deals with basic concepts of volume distribution, the second most important parameter in pharmacokinetics but often challenging for students clinical pharmacology.Its relationships dose, concentration and amount body are discussed using a physical model examples commonly used drugs, as well its physiological aspects pertaining to differing organs.Finally, application distribution calculation loading dose half-life is show how it essential pharmacotherapy pharmacology.
The population pharmacokinetic (PK) parameters that are implemented in therapeutic drug management (TDM) software were generally obtained from a Western and might not be adequate for PK prediction with Korean population. This study aimed to develop model vancomycin using data improve the quality of TDM patients. A total 220 patients (1020 observations) who received services included dataset. analysis was performed non-linear mixed effects modeling, covariate evaluation conducted....
The pharmacokinetic (PK) property of fluconazole might be significantly altered in major burn patients by medical interventions and physiologic changes. In this study, our aims were to investigate PK using a population approach recommend the optimal regimen based upon predicted therapeutic outcome. At steady state, blood samples for analysis obtained from 60 receiving between 100 ~400 mg daily. A mixed-effect modeling was performed outcome antifungal therapy 10,000 virtual NONMEM (version...
To determine population-based pharmacokinetic parameters for intravenous valproic acid, and the factors influencing these parameters, in Korean adults.Valproic acid concentrations were obtained using a peak trough sampling scheme 102 epileptic patients who not taking concurrent antiepileptic medication. Three hundred fifty-four serum analysed according to one-compartment model with mixed effect modelling method (NONMEM Ver 5.0). The influence of body-weight (kg), height, daily dose (mg/day),...
CYP1A2, CYP2D6 and N-acetyltransferase activities were estimated in 100 patients with bladder cancer 84 control subjects from measurements of theophylline, metoprolol isoniazid their metabolites urine, respectively. The frequency occurrence slow acetylators poor metabolizers 16.7% 1.2% the group 16.3% 2.0% patient group. These differences not significant. recovery ratio 1-methyluric acid(1-MU) theophylline was significantly higher than subjects(0.340 +/- 0.016 versus 0.260 0.020, p < 0.05)....