A5023499634- Glutathione Transferases and Polymorphisms
- Carcinogens and Genotoxicity Assessment
- Genomics, phytochemicals, and oxidative stress
- Epigenetics and DNA Methylation
- BRCA gene mutations in cancer
- Air Quality and Health Impacts
- Research in Social Sciences
- Pharmacogenetics and Drug Metabolism
- DNA Repair Mechanisms
- Occupational and environmental lung diseases
- Nutrition, Genetics, and Disease
- Estrogen and related hormone effects
- Polyamine Metabolism and Applications
- Workplace Health and Well-being
- Occupational exposure and asthma
- Amino Acid Enzymes and Metabolism
- Stress Responses and Cortisol
- Osteoarthritis Treatment and Mechanisms
- Information Technology Governance and Strategy
- Cancer Risks and Factors
- Asthma and respiratory diseases
- Folate and B Vitamins Research
- Indoor Air Quality and Microbial Exposure
- Law in Society and Culture
- European and International Law Studies
McGill University
2023
University of Jyväskylä
2021-2023
Defence Academy of the United Kingdom
2023
Cranfield University
2023
University of Helsinki
1988-2021
Finnish Institute of Occupational Health
2010-2019
Finnish Institute for Health and Welfare
2019
Finnish Society of Sciences and Letters
2004-2017
Polícia Judiciária
2006-2017
Research Council of Finland
2004-2013
Susceptibility to lung cancer may in part be attributable inter-individual variability metabolic activation or detoxification of tobacco carcinogens. The glutathione S-transferase M1 (GSTM1) genetic polymorphism has been extensively studied this context; two recent meta-analyses case-control studies suggested an association between GSTM1 deletion and cancer. At least 15 have published after these overviews. We undertook a new meta-analysis summarize the results 43 including >18 000...
The identification of genetic traits that predispose individuals to environmentally induced cancers is one the challenges in assessment individual cancer risk. For this reason, variations expression enzymes involved biotransformation reactions have been extensively studied. One such polymorphic enzyme GSTM1, which belongs class Mu glutathione S-transferases (GSTs), and only expressed 55–60% Caucasians. Previous data suggest smokers lacking GSTM1activity may be at greater risk developing lung...
Glutathione S-transferases (GSTs) are known to take part in detoxification of many potentially carcinogenic compounds. Therefore, polymorphisms the GST genes have been considered as important modifiers individual risk environmentally induced cancers. The association between lack glutathione S-transferase M1 gene (GSTM1 null genotype) and susceptibility smoking-related lung cancer has actively studied, with contradictory results. In contrast, little is about more recently found GSTM3, GSTP1...
Cytochrome P450 2A6 is an important human hepatic which activates pre‐carcinogens, oxidises some drugs and constitutes the major nicotine C ‐oxidase. In fact, results have been presented in literature suggested a relationship between distribution of defective CYP2A6 alleles smoking behaviour as well cigarette consumption. present report, we describe structure novel CYP2A locus where whole gene has deleted, resulting abolished cytochrome 2A6‐dependent metabolism. The origin this apparently...
The relationships between smoking and the expression of glutathione S-transferase (GST*) isozymes GSTM1-1, GSTM3-3, GSTP1-1 GSTA1-1/2-2 (GSTA1/2), or activities epoxide hydrolase (EH) aryl hydrocarbon hydroxylase (AHH) were investigated in lung samples from 27 patients with cancer 11 control by immunoblot analysis enzyme assays. Determination genotypes blood leucocyte DNA showed that possession mu-class GSTM1 gene was closely related to GSTM1-1 GSTM3-3 enzymes cytosol: null genotype had no...
The purpose of this study is to perform a multiparametric analysis on the environmental factors, physiological stress reactions in body, measured alertness, and subjective symptoms during simulated office work. Volunteer male subjects were monitored three 4-hr work meetings an room, both ventilated non-ventilated environment. parameters included CO(2), temperature, relative humidity. test battery consisted measuring autonomic nervous system functions, salivary hormones, blood's CO(2)-...
Cancer and cardiovascular diseases share risk factors such as smoking, the onset of both have been suggested to a common mechanistic basis. The binding carcinogens DNA (carcinogen-DNA adducts), genetic polymorphisms in carcinogen-detoxifying enzymes glutathione S-transferases (GSTs), vitamin D receptor (VDR) are among candidates for modifiers cancer risk. We determined whether these biomarkers could be related individual characteristics patients suffering from diseases. For that purpose,...
Background Humans vary in their ability to metabolize endogenous and exogenous compounds. Glutathione S-transferases (GSTs) N -acetyltrans-ferases(NATs) are enzymes involved the detoxification of hazardous agents. The GSTM1 GSTT1 genes exhibit null (i.e., deletion) polymorphisms; specific individuals, homozygous deletion both copies lost) these can be detected. Polymorphism NAT2 gene results slow fast acetylators potentially toxic substances. GSTM1-null slow-acetylator genotypes have been...
Mutagen sensitivity, measuring the extent of chromosome damage induced by an in vitro treatment peripheral lymphocytes with bleomycin, has been associated increased risk various human cancers. Sensitivity to bleomycin appears have high heritability and is usually considered reflect individual capacity repair DNA lesions. Another potential contributor variation sensitivity could be inherited differences metabolism bleomycin. We assessed whether genetic polymorphisms xenobiotic-metabolizing...
The individual genotoxic response of cultured human lymphocytes to diepoxybutane (DEB), an epoxide metabolite 1,3-butadiene, shows a bimodal distribution. Blood donors can be classified as either DEB-sensitive or DEB-resistant on the basis frequency sister chromatid exchanges (SCEs) induced by DEB in whole-blood lymphocyte cultures. genetic this phenomenon has thusfar been unknown. To investigate if differences ability individuals detoxify could explain response, 48-h treatment with (2 and...
We investigated point mutational DraI and RsaI restriction fragment length polymorphisms (RFLPs) in the CYP2E1 gene 101 lung cancer patients, 40 patients with other pulmonary diseases 121 healthy control subjects. In RFLP analysis of subjects, 96 had DD genotype, 24 CD genotype one CC genotype. Genotypic distribution disease showed a similar trend (P = 0.50), though group was considerably smaller. The genotypes not significantly different from that controls 0.44). were able to reproduce...
Abstract CYP1A1 is involved in the metabolism of benzopyrene, a suspected lung carcinogen; it therefore conceivable that genetically determined variations its activity modify individual susceptibility to cancer. The role MspI polymorphism cancer has been widely studied but not fully clarified. We have included 2,451 cases and 3,358 controls pooled analysis 22 case‐control studies on risk. found clear association between homozygous restriction fragment length (RFLP) risk Caucasians (age‐...
This study identifies the effects of sleep restriction and subsequent recovery on glucose homeostasis, serum leptin levels, feelings subjective satiety. Twenty-three healthy young men were allocated to a control group (CON) or an experimental (EXP) group. After two nights 8 h in bed (baseline, BL), EXP spent 4 for five days (sleep restriction, SR), followed by (recovery, REC). CON throughout study. Blood samples taken after BL, SR, REC period. In EXP, insulin insulin-to-glucose ratio...
To evaluate the potential association between GSTM1 and GSTT1 genotypes development of breast cancer, a hospital based case-control study was conducted in South Korean population consisting 189 histologically confirmed incident cancer cases their age-matched control subjects with no present or previous history cancer. A multiplex polymerase chain reaction method used for genotyping analyses statistical evaluations were performed by unconditional logistic regression model. The null genotype...