A5016202108- Glutathione Transferases and Polymorphisms
- Carcinogens and Genotoxicity Assessment
- Genomics, phytochemicals, and oxidative stress
- Toxic Organic Pollutants Impact
- Parkinson's Disease Mechanisms and Treatments
- Systemic Lupus Erythematosus Research
- Epigenetics and DNA Methylation
- Effects and risks of endocrine disrupting chemicals
- Lung Cancer Treatments and Mutations
- Folate and B Vitamins Research
- Dermatology and Skin Diseases
- BRCA gene mutations in cancer
- Atherosclerosis and Cardiovascular Diseases
- Pharmacogenetics and Drug Metabolism
- Gut microbiota and health
- DNA Repair Mechanisms
- Asthma and respiratory diseases
- Alcohol Consumption and Health Effects
- Inflammasome and immune disorders
- T-cell and B-cell Immunology
- Nutrition, Genetics, and Disease
- Infant Health and Development
- Rheumatoid Arthritis Research and Therapies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Air Quality and Health Impacts
Kyushu University
2013-2022
Kyushu University Beppu Hospital
2014
Miyazaki Prefectural Hospital
2010
Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital
2010
Kyushu Hospital
2010
Kyoto University
2010
Sapporo Medical University
2009
St. Mary's College
2009
Saga University
2009
National Yang Ming Chiao Tung University
2008
The influence of antibiotic exposure in the early postnatal period on development intestinal microbiota was monitored 26 infants including five antibiotic-treated (AT) subjects orally administered a broad-spectrum for first 4 days life and three caesarean-delivered (CD) whose mothers were intravenously injected by similar type antibiotics same period. faecal bacterial composition analysed daily 5 monthly 2 months. Terminal restriction fragment length polymor-phisms AT showed less diversity...
The purpose of the present review is to evaluate effects common risk factors for suicide by meta-analyses using data extracted from studies based on psychological autopsy method. We focused five suicide: substance-related disorders, mood adverse marital status, employment and self-harm behaviors. A total 24 articles were identified MEDLINE in which crude odds ratio (OR) could be calculated above through 30 April 2007, such search keywords as "suicide," "psychological autopsy," "case-control...
Abstract Asia differs substantially among and within its regions populated by diverse ethnic groups, which maintain their own respective cultures dietary habits. To address the diversity in gut microbiota, we characterized bacterial community fecal samples obtained from 303 school-age children living urban or rural five countries spanning temperate tropical areas of Asia. The microbiota profiled for subjects were classified into two enterotype-like clusters, each driven Prevotella (P-type)...
While the association between exposure to secondhand smoke and lung cancer risk is well established, few studies with sufficient power have examined by histological type. In this study, we evaluated smoke-lung relationship type based on pooled data from 18 case–control in International Lung Cancer Consortium (ILCCO), including 2,504 cases 7,276 control who were never smokers 10,184 7,176 controls ever smokers. We used multivariable logistic regression, adjusting for age, sex, race/ethnicity,...
Abstract CYP1A1 is involved in the metabolism of benzopyrene, a suspected lung carcinogen; it therefore conceivable that genetically determined variations its activity modify individual susceptibility to cancer. The role MspI polymorphism cancer has been widely studied but not fully clarified. We have included 2,451 cases and 3,358 controls pooled analysis 22 case‐control studies on risk. found clear association between homozygous restriction fragment length (RFLP) risk Caucasians (age‐...
We examined the relationship between aryl hydrocarbon hydroxylase (AHH) and frequency of a Msp I mutation in 3′‐flanking region cytochrome P450 (CYP) 1A1 (Mspl polymorphism) another exon 7 (Ile‐Val 84 healthy male subjects Fukuoka, Japan. AHH inducibility (3‐methylcholanthrene (MC)‐induced activity/non‐induced activity) was correlated with MspI polymorphism (P<0.0001) age class (P=0.015), whereas no correlation found for Ile‐Val (P=0.509). Age‐adjusted (mean±SE) predominant homozygote...
Background. An ecological analysis found that the docosahexaenoic acid content in mother's milk and seafood intake were inversely correlated with postpartum depression. This prospective study investigated relationship of consumption selected high-fat foods specific types fatty acids risk Method. The subjects 865 Japanese women. Dietary data obtained from a self-administered diet history questionnaire during pregnancy. Edinburgh Postnatal Depression Scale (EPDS) was used for evaluation...
Abstract Background: The International Lung Cancer Consortium was established in 2004. To clarify the role of DNA repair genes lung cancer susceptibility, we conducted a pooled analysis genetic variants pathways, whose associations have been investigated by at least 3 individual studies. Methods: Data from 14 studies were for 18 sequence 12 genes, including APEX1, OGG1, XRCC1, XRCC2, XRCC3, ERCC1, XPD, XPF, XPG, XPA, MGMT, and TP53. total number subjects included each variant ranged 2,073 to...
antioxidant vitamins are expected to protect cells from oxidative damage by neutralizing the effects of reactive oxygen species. However, epidemiological evidence regarding associations between vitamin intake and Parkinson's disease (PD) is limited inconsistent. We investigated relationship dietary selected vitamins, vegetables fruit risk PD in Japan using data a multicenter hospital-based case-control study.included were 249 patients within 6 years onset PD. Controls 368 inpatients...
Increased homocysteine levels might accelerate dopaminergic cell death in Parkinson's disease (PD) through neurotoxic effects; thus, increasing intake of B vitamins involved the regulation metabolism decrease risk PD decreasing plasma homocysteine. However, epidemiological evidence for association dietary with is sparse, particularly non-Western populations. We conducted a hospital-based case–control study Japan to examine associations between folate, vitamin 6 , 12 and riboflavin PD....
We investigated the correlation between fecal bacteria composition in early infancy and prevalence of allergic diseases late infancy. The microbiota first 2 months was profiled using 16S rRNA V6 short-tag sequences community statistically compared two groups subjects who did not show symptoms years (n = 11 vs. 11). In group, genus Bacteroides at 1 month genera Propionibacterium Klebsiella were more abundant, Acinetobacter Clostridium less abundant than nonallergic group. Allergic infants...
Progranulin (PGRN) is the precursor of granulin (GRN), a soluble cofactor for toll-like receptor 9 (TLR9) signaling evoked by oligonucleotide (CpG)-DNA. Because TLR9 plays an important role in systemic lupus erythematosus (SLE), we investigated whether PGRN involved pathogenesis SLE. We measured concentrations serum and interleukin-6 (IL-6) with enzyme-linked immunosorbent assay (ELISA) patients SLE (n = 68) healthy controls 60). assessed correlation between levels established...
Obesity has been related to increased risk of colon cancer or adenomas, but the epidemiologic findings are not entirely consistent. We examined relation only body mass index (BMI) also waist-to-hip ratio (WHR) and weight gain adenoma in men who received a preretirement health examination at Japan Self Defense Forces (SDF) Fukuoka Kumamoto Hospitals during period from 1995 1996. In series 803 age 47-55 years, 189 cases adenomas 226 controls with normal total colonoscopy were identified....
Consumption of caffeine-rich beverages, which have diuretic properties, may decrease serum uric acid concentrations. We examined cross-sectionally the relationship coffee and green tea consumption to concentrations in 2240 male self-defence officials who received a pre-retirement health examination at four hospitals Self-Defence Forces between 1993 1994. The mean levels were 2.3 3.1 cups/d respectively. There was clear inverse concentration. When adjusted for hospital only, those consuming...