A5052214025- Occupational and environmental lung diseases
- Occupational exposure and asthma
- Air Quality and Health Impacts
- Genomic variations and chromosomal abnormalities
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- Occupational Health and Safety Research
- Glutathione Transferases and Polymorphisms
- Pharmacogenetics and Drug Metabolism
- Genetic factors in colorectal cancer
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pleural and Pulmonary Diseases
- Indoor Air Quality and Microbial Exposure
- Research in Social Sciences
- Cancer-related Molecular Pathways
- Asthma and respiratory diseases
- Radiation Dose and Imaging
- Epigenetics and DNA Methylation
- Carcinogens and Genotoxicity Assessment
- Medical Imaging and Pathology Studies
- RNA modifications and cancer
- Caveolin-1 and cellular processes
- Workplace Health and Well-being
- Lung Cancer Diagnosis and Treatment
Stora Enso (Finland)
2023
University of Eastern Finland
2010-2023
Finland University
2021
European Chemicals Agency
2016
Finnish Safety and Chemicals Agency
2016
University of Dundee
2015
Finnish Institute of Occupational Health
2002-2013
Helsinki University Hospital
2001-2013
Statistical Service
2013
Finnish Defence Forces
2013
This study attempts to estimate the proportion of annual deaths related occupational factors in Finland and considers methodological issues associated uncertainties.Statistics on causes death, numbers subjects exposed, risk ratios obtained from epidemiologic literature were used population attributable fraction disease burden for death work-related diseases. Gender-, age- disease-specific provided by Statistics 1996. Information size population, broken down gender, age, occupation, industry,...
There are no population-based follow-up studies to estimate the fraction of asthma incidence that is attributable work. In Finland, individuals with clinically well-established persistent registered for reimbursement medication from national health insurance scheme. We combined, at an individual level, these data population census 1985, 1990, and 1995 work in adult-onset asthma. Our study covered entire 25- 59-yr-old employed Finland 1986-1998. Relative risks (RR) occupational categories...
Glutathione S-transferases (GSTs) are known to take part in detoxification of many potentially carcinogenic compounds. Therefore, polymorphisms the GST genes have been considered as important modifiers individual risk environmentally induced cancers. The association between lack glutathione S-transferase M1 gene (GSTM1 null genotype) and susceptibility smoking-related lung cancer has actively studied, with contradictory results. In contrast, little is about more recently found GSTM3, GSTP1...
High mobility group A (HMGA) proteins play an important role in the regulation of transcription, differentiation, and neoplastic transformation. In this work, expression HMGA 1 2 152 lung carcinomas mainly non-small-cell histological type has been studied by immunohistochemistry order to evaluate their feasibility as cancer markers. 17 cases, related bronchial epithelial changes were also for HMGA1 expression. RNA HMGA1a b isoforms HMGA2 was determined real-time semi-quantitative RT-PCR 23...
Systematic research on occupation or industry-specific incidence of occupational asthma (OA) is sparse. We calculated the notified OA by occupation, industry and causative agent in Finland for years 1989-95.The numbers cases reported were retrieved from Finnish Registry Occupational Diseases population between 20 64 age. The employed workers Statistics Finland. Incidence rates each total workforce.Altogether 2602 mean annual rate was 17.4 cases/100,000 workers. highest bakers, other painters...
Previous cross-sectional and prevalent case-control studies have suggested increased risk of asthma in adults related to dampness problems molds homes. We conducted a population-based incident study assess the effects indoor at work home on development adults. recruited systematically all new cases during 2.5-year period (1997-2000) randomly selected controls from source population consisting 21-63 years old living Pirkanmaa Hospital district, South Finland. The clinically diagnosed case...
Microscopic techniques for analysing asbestos fibres in lung tissue and bronchoalveolar lavage have provided major information the understanding of asbestos-related diseases. These analyses are increasingly applied clinical work medicolegal problems. Differences sampling, preparation counting techniques, definitions reference populations expression results caused difficulties comparing from different laboratories. Therefore it appeared necessary to set a goal harmonize these between European...
Abstract We investigated point mutational activation of the ras genes (K‐ codons 12, 13 and 61; N‐ H‐ 12 61) in primary, resected lung cancer by dot blotting oligonucleotide hybridization. K‐ mutations were found 14 (29%) 48 tumour specimens examined, but no or found. The highest frequency mutation was observed adenocarcinoma: 21 samples studied (57%) had a mutation, which is one frequencies reported for adenocarcinoma. commonest type these consisted transversions: we 11, 8 (57% all...
Abstract A specific member of the cytochrome P450 super‐family enzymes, designated P450IA (including 2 isozymes, P450IAI and P450IA2), which is involved in metabolic activation polycyciic aromatic hydrocarbons amines, was studied lung tissue from 25 cancer patients by immunohistochemistry. The pulmonary activity a P450IAI‐dependent enzyme, aryl hydrocarbon hydroxylase (AHH), same also measured. Cytochrome P4S0IA localized principally peripheral airways alveolar epithelium types I II ciliated...
We investigated point mutational DraI and RsaI restriction fragment length polymorphisms (RFLPs) in the CYP2E1 gene 101 lung cancer patients, 40 patients with other pulmonary diseases 121 healthy control subjects. In RFLP analysis of subjects, 96 had DD genotype, 24 CD genotype one CC genotype. Genotypic distribution disease showed a similar trend (P = 0.50), though group was considerably smaller. The genotypes not significantly different from that controls 0.44). were able to reproduce...
In response to the health risks posed by asbestos exposure, some countries have imposed strict regulations and adopted bans, whereas other intervened less continue use varying quantities of asbestos.
We performed a comparative genomic hybridization study on 25 samples of adenocarcinoma and 19 squamous cell carcinoma the lung to detect recurrent changes in genetic material. DNA copy number were found 16 17 samples. The most common gains sequences 3q (43%), 1q (34%), 8q (32%), 5p, (30%), 7p (25%), 12p (25%). Of with changes, 94% (15/16) had gain (minimal region overlap q24-qter), whereas only 24% (4/17) showed (q22-qter) (P< 0.001). Six high-level amplifications (q26.2-q26.3) detected but...
Because TP53 mutations can induce an immune response and occur early in the carcinogenic process for some tumors, p53 autoantibodies may be useful biomarkers risk of development cancer. Using banked serum samples from asbestosis cohort at high cancer, we demonstrate first time a statistically significant relationship between subsequent malignancy (hazard ratio [HR] = 5.5, 95% confidence interval [CI] 2.8-10.9) with positive predictive value 0.76 average lead to diagnosis 3.5 years. were also...
Human pulmonary tissues are known to contain enzymes mediating procarcinogen activation. Peripheral blood lymphocytes and bronchoalveolar macrophages (BAMs) have been used as surrogates for the lung in studies involving cytochrome P450 (CYP) parameters, including CYP1A1 inducibility relation susceptibility cancer. In this study, a comprehensive view of expression patterns xenobiotic-metabolizing CYP forms human BAMs peripheral was obtained by using gene-specific reverse...
The incidence and risk of asthma among female cleaners employed in different industries was explored. An increased has been associated with the cleaning profession, some but not all studies. All Finnish females as those administrative work were followed for through a record linkage 1986–1998. individual defined an “incident case asthma” if they received rights special reimbursement medication from national health insurance or recognized having occupational asthma. Age-adjusted relative risks...
Induction of a polycyclic aromatic hydrocarbon-metabolizing cytochrome P450 isoform CYP1A1 is regulated by hydrocarbon receptor (AHR). High inducibility CYP1A1, possibly due to genetic polymorphisms, has been considered be risk factor for lung cancer in tobacco smokers. The relationship between low or high pulmonary expression and polymorphic genotypes AHR was investigated 73 active determined surgical samples measuring ethoxyresorufin O-deethylase (EROD) activity immunostaining protein....
This population-based cross-sectional survey assessed the prevalence of work-aggravated asthma symptoms and effect work environment on aggravation established asthma. A questionnaire was sent to 2,613 persons (aged 20–65 yrs) with The analyses were restricted 969 respondents who currently employed. occupational exposure at according both self-reported expert-evaluated exposure. Approximately 21% reported least weekly during past month. those increased by age, dusts, abnormal temperatures or...