A5103277294- Acute Myeloid Leukemia Research
- Hematopoietic Stem Cell Transplantation
- Radiomics and Machine Learning in Medical Imaging
- Multiple Myeloma Research and Treatments
- Rheumatoid Arthritis Research and Therapies
- Cancer Genomics and Diagnostics
- Metallurgical Processes and Thermodynamics
- Sports Performance and Training
- Cancer Immunotherapy and Biomarkers
- Chronic Myeloid Leukemia Treatments
- AI in cancer detection
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Genetics and Physical Performance
- Cytomegalovirus and herpesvirus research
- Chronic Lymphocytic Leukemia Research
- Metal Extraction and Bioleaching
- Systemic Lupus Erythematosus Research
- Minerals Flotation and Separation Techniques
- Educational Systems and Policies
- Polyomavirus and related diseases
- Mesenchymal stem cell research
- Protein Degradation and Inhibitors
- Cardiovascular Effects of Exercise
- Immune Cell Function and Interaction
- Education and Learning Interventions
Yonsei University
2010-2024
Severance Hospital
2022-2024
Catholic University of Korea
2013-2023
Seoul National University Bundang Hospital
2019-2023
Seoul St. Mary's Hospital
2011-2023
Korea Air Force Academy
2021-2023
Eunpyeong Hospital
2023
Tohoku University
2021-2023
Chosun University
2018-2021
Korean Red Cross
2021
Abstract Tumor-infiltrating lymphocytes (TILs) have been recognized as key players in the tumor microenvironment of breast cancer, but substantial interobserver variability among pathologists has impeded its utility a biomarker. We developed deep learning (DL)-based TIL analyzer to evaluate stromal TILs (sTILs) cancer. Three evaluated 402 whole slide images cancer and interpreted sTIL scores. A standalone performance DL model was 210 cases (52.2%) exhibiting score differences less than 10...
Objective To evaluate clinical effectiveness of regdanvimab, a monoclonal antibody agent for treating coronavirus 2019 (COVID-19). Methods A retrospective cohort study was conducted at two general hospitals during the period December 2020 to May 2021. Mild COVID-19 patients with risk factors disease progression admitted within seven days symptom onset were enrolled and followed until discharge or referral. Multivariate analyses in total propensity score (PS)-matched cohorts. Results 778 mild...
To weigh the pros and cons of familial-mismatched/haploidentical transplantation (FMT) in patients with high-risk acute myelogenous leukemia, we assessed outcomes 23 who underwent FMT, using reduced-intensity conditioning total body irradiation 800 cGy/busulfan/fludarabine/antithymocyte globulin without ex vivo T cell depletion, compared to 33 well-matched unrelated donor (WM-UDT) 13 partially matched (PM-UDT) during same period. The FMT had not only a similar pattern engraftment immune...
This report focuses on the adaptive phase I trial design aimed to find clinically applicable dose for decitabine maintenance treatment after allogeneic hematopoietic stem cell transplantation in patients with higher-risk myelodysplastic syndrome and secondary acute myeloid leukemia. The first cohort (three patients) was given same initial daily of (5 mg/m2/day, five consecutive days 4-week intervals). In all cohorts, doses Cycles 2 4 were individualized using pharmacokinetic-pharmacodynamic...
The goal of induction therapy for multiple myeloma (MM) is to achieve adequate disease control. Current guidelines favor triplet (bortezomib-lenalidomide-dexamethasone; VRd) or quadruplet regimens (daratumumab, bortezomib-thalidomide-dexamethasone; D-VTd). In the absence a direct comparison between two treatment regimens, we conducted this study compare outcomes and safety VRd D-VTd.Newly diagnosed MM patients aged ＞18 years who underwent followed by autologous stem cell transplantation...
Using real-time quantitative PCR, we monitored Wilms tumor gene 1 (WT1) expression from diagnosis to hematopoietic stem cell transplantation (HSCT) in adult patients with cytogenetically normal acute myelogenous leukemia (CN-AML) and FLT3-ITD NPM1 mutations. The values at were evaluated 104 patients. Data collected after induction chemotherapy available for all patients, but only 68 treated HSCT. Significant WT1 cut-offs determined by receiver operation characteristic curve analysis, rates...
The pathophysiology underlying anxiety disorders involves stress and associated increases in glucocorticoid levels the blood. present study investigated effects of administration crude extract Polygala tenuifolia (EPT) on repeated restraint stress–induced anxiety-like behavioral responses mice. Additionally, possible changes central noradrenergic brain-derived neurotrophic factor (BDNF)–signaling systems were assessed hippocampus these For 14 consecutive days, mice orally administrated EPT...
Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders characterized by the proliferation of one or more myeloid lineages. The current study demonstrates that three driver mutations were detected in 82.6% 407 MPNs with a mutation distribution JAK2 275 (67.6%), CALR 55 (13.5%) and MPL 6 (1.5%). mutually exclusive principle except patient both mutations. directed pathologic features MPNs, including lineage hyperplasia, laboratory findings clinical presentation....
We examined the association between socioeconomic status (SES) and comorbidity distribution among patients with RA.Information on comprehensive health of 1088 RA (weighted n = 612 303) was obtained from 2007-2015 Korea National Health Nutrition Examination Survey database. SES components were household equivalence income, education area residence. To minimize confounding by age, stratified median age (63 years). Age-adjusted odds ratio (OR) 95% confidence interval (95% CI) estimated,...
We analyzed the outcome of stem cell transplantation (SCT) for 59 acute myeloid leukemia (AML) patients with t(8;21). The 5-year overall and disease-free survival (OS DFS) were 70.2 68.4%, respectively. cumulative incidence relapse (CIR) nonrelapse mortality 16.9 13.6%, OS DFS in reduced-intensity conditioning (RIC)-SCT group (70.4%) not different from autologous SCT (ASCT) (72.4 69.0%, respectively). Age was a factor affecting (p = 0.007) 0.008) ASCT group, but RIC-SCT group. In lack X...
The current definition of complete response (CR) in multiple myeloma (MM) includes negative serum and urine immunofixation (IFE) tests <5% bone marrow plasma cells (BMPCs). However, many studies the prognostic impact pretransplant have not included BMPCs. We evaluated BMPC assessment before peripheral blood stem cell (PBSC) mobilization on subsequent transplant outcomes. BMPCs were assessed by CD138, kappa, lambda immunostaining 106 patients. After a median followup 24.5 months, patients...
Abstract Extracellular PKM2 (exPKM2) levels have been reported to be increased in several cancers and inflammatory diseases, including rheumatoid arthritis (RA). This study aimed investigate the association of circulating exPKM2 with radiographic progression RA patients effect on osteoclastogenesis. Plasma synovial fluid were significantly elevated patients. correlated disease activity an independent predictor for a duration ≤ 12 months. CD14 + monocytes but not fibroblast-like synoviocytes...
BACKGROUND: This study aimed to investigate the relationships among ACTN-3, body composition, fitness, and +Gz tolerance for senior cadet training development their safe task performance.METHODS: The subjects were all cadets (N = 68) at Korea Air Force Academy. All are required pass a physical fitness test (3-km running, sit-ups, push-ups) composition on semiannual basis. Isokinetic muscle function (strength endurance), (+6 Gz ⋅ 30 s-1), target gene (ACTN-3) analyzed.RESULTS: effects of...
The expression of the SOCS genes in cytomegalovirus (CMV) viremia after hematopoietic stem cell transplantation (HSCT) remains largely unexplored.Using quantitative RT-PCR mononuclear cells, we conducted pairwise comparison SOCS1 and SOCS3 levels among a healthy donor group (N=55), pre-HSCT (N=17), recipient subgroup (N=107), which were divided according to occurrence CMV acute graft-versus-host disease (aGVHD).Compared that group, was higher CMV+ subgroup, especially CMV+GVHD- but decreased...
<h3>Background</h3> Rheumatoid arthritis (RA) is a chronic auto-immune disease that more common to female than male. Gender-based differences in clinical features, comorbidities, and outcomes have been fragmentarily described. However, systematic analysis focusing on gender large RA population scarce. <h3>Objectives</h3> We aimed elucidate characteristics comorbidities their potential impact outcome Korean cohort of patients with RA. <h3>Methods</h3> A total 5,376 were included from the...
Newly diagnosed multiple myeloma (NDMM) frequently results in renal impairment (RI), and its natural course has not been fully elucidated the era of novel agents. We aimed to identify dynamics function after autologous stem cell transplantation (ASCT) following induction treatment using a agent transplantation-eligible NDMM patients with RI (estimated glomerular filtration rate [eGFR] ≤50 mL/min/1.73 m2) at diagnosis. The factors associated achieving response based on term benefit regardless...
Background: Repair of rotator cuff tear is not always feasible, depending on the severity. Although several studies have investigated factors related to reparability and various methods predict it, inconsistent scoring a lack validation hindered utility these methods. Purpose: To develop machine learning models tears, compare them with previous systems, provide an accessible online model. Study Design: Cohort study; Level evidence, 3. Methods: Arthroscopic repairs for tears both...
2607 Background: Tumor infiltrating lymphocytes (TIL) are a potential tumor-agnostic biomarker for immune checkpoint inhibitor (ICI) therapy. We previously reported the clinical application of an artificial intelligence-powered spatial TIL analyzer, Lunit SCOPE IO, predicting ICI treatment outcomes in advanced non-small cell lung cancer (NSCLC). Here, we expand IO as across multiple types. Methods: was trained and validated with 2.8 x 10 9 micrometer 2 area 5.9 6 TILs from 3,166 H&E...