A5101523918- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- Protein Degradation and Inhibitors
- CNS Lymphoma Diagnosis and Treatment
- Viral-associated cancers and disorders
- Autophagy in Disease and Therapy
- Multiple Myeloma Research and Treatments
- Hematopoietic Stem Cell Transplantation
- Chronic Lymphocytic Leukemia Research
- Immune Cell Function and Interaction
- Glioma Diagnosis and Treatment
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Mycobacterium research and diagnosis
- Retinoids in leukemia and cellular processes
- Infectious Diseases and Tuberculosis
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Hematological disorders and diagnostics
- Tuberculosis Research and Epidemiology
- Peptidase Inhibition and Analysis
- CAR-T cell therapy research
- Liver Disease Diagnosis and Treatment
- Chronic Myeloid Leukemia Treatments
- Acute Lymphoblastic Leukemia research
- Nerve injury and regeneration
Catholic University of Korea
2022-2024
Seoul St. Mary's Hospital
2022-2024
Yonsei University
2013-2020
Severance Hospital
2015-2020
Wonju Severance Christian Hospital
2018
Dong-A University
2016
Gangnam Severance Hospital
2016
National Taiwan University Hospital
2011-2012
Ulsan College
2004-2005
University of Ulsan
2004-2005
Abstract Purpose: Bromodomain and extraterminal domain (BET) inhibitors are promising epigenetic agents for the treatment of various subsets acute myeloid leukemia (AML). However, resistance stem cells (LSC) to BET remains a major challenge. In this study, we evaluated mechanisms underlying LSC inhibitor JQ1. Experimental Design: We levels apoptosis autophagy induced by JQ1 in LSC-like cell lines primary CD34+CD38− leukemic blasts obtained from AML cases with normal karyotype without...
The efficacy of sequential therapy and the applicability genotypic resistance to guide selection antibiotics in third-line treatment Helicobacter pylori have not been reported. We aimed assess resistance-guided treatment. Genotypic phenotypic resistances were determined patients who failed at least two eradication therapies by PCR with direct sequencing agar dilution test, respectively. retreated containing esomeprazole amoxicillin for first 7 days, followed metronidazole plus...
Bromodomain and extraterminal domain (BET) inhibitors are promising epigenetic agents for the treatment of various subsets acute myeloid leukemia (AML). However, resistance stem cells (LSCs) to BET remains a major challenge. In this study, we evaluated mechanisms underlying LSC inhibitor JQ1. We levels apoptosis macroautophagy/autophagy induced by JQ1 in LSC-like cell lines primary CD34+ CD38- leukemic blasts obtained from AML cases with normal karyotype without recurrent mutations....
Sequential therapy appears to achieve a higher Helicobacter pylori eradication rate than triple therapy. We assessed the efficacy and tolerability of modified sequential containing levofloxacin high-dose esomeprazole in second-line therapy.Patients who failed first-line with clarithromycin, amoxicillin proton pump inhibitor were eligible this multicentre trial. Eligible patients treated 40 mg 1 g for first 5 days, followed by mg, 250 metronidazole 500 another days (all given twice daily)....
Isolated myeloid sarcoma (MS) is a rare extramedullary tumor mass composed of malignant precursor cells without any evidence leukemia in the peripheral blood and bone marrow. We describe clinical characteristics outcomes patients diagnosed with isolated MS at our institution.We retrospectively reviewed 9 497 acute (AML) (1.8%) MS. were divided into 2 groups according to first-line treatment strategy: systemic only (S) or local (LS).The most common site occurrence was head neck area (N=4,...
The goal of induction therapy for multiple myeloma (MM) is to achieve adequate disease control. Current guidelines favor triplet (bortezomib-lenalidomide-dexamethasone; VRd) or quadruplet regimens (daratumumab, bortezomib-thalidomide-dexamethasone; D-VTd). In the absence a direct comparison between two treatment regimens, we conducted this study compare outcomes and safety VRd D-VTd.Newly diagnosed MM patients aged ＞18 years who underwent followed by autologous stem cell transplantation...
Factors for Severe Bacterial Infection in Patients with Multiple Myeloma during Treatment Bortezomib-based RegimensThe aim of this study was to identify the risk factors associated severe bacterial infection (SBI) multiple myeloma (MM) patients treatment bortezomibbased regimens.A total 98 MM were evaluated 427 courses.SBI occurred 57.1% (56/98) and 19.0%(81/427) courses.In multivariate analysis development SBI each course, poor performance status (Eastern Cooperative Oncology Group ≥ 2, P <...
Background The incidence of nontuberculous mycobacterium (NTM) infections in Korea is increasing. This retrospective study was performed to examine the recovery rate NTM from respiratory specimens as well isolated colony characteristics, and assess clinical significance a isolation. Methods results requested for an acid-fast bacilli (AFB) examination during 2002 at Asan Medical Center, along with patients characteristics were analyzed. Results A total 26,820 smear culture period. proportion...
Few studies have evaluated the risk factors for hepatic sinusoidal obstructive syndrome (SOS) in patients with malignant lymphoma receiving autologous stem cell transplantation (ASCT). We retrospectively analyzed 132 who underwent ASCT. Intravenous busulfan-based conditioning regimens were used 108 (81.8%) patients. The combination of heparin and ursodeoxycholic acid was prophylaxis SOS. Hepatic SOS developed 10 (7.6%) at a median 30 days post-ASCT. In nine (90.0%) patients, diagnosed after...
Upfront autologous stem cell transplantation (ASCT) has shown favourable outcome in patients with primary central nervous system lymphoma (PCNSL), but the role of risk-adapted upfront ASCT consolidation not been evaluated PCNSL. As PCNSL International Extranodal Lymphoma Study Group (IELSG) prognostic score ≥2 or those who did achieve complete response after two courses induction chemotherapy (non-CR1) have inferior outcomes, we retrospectively analysed 66 high-risk (IELSG and/or non-CR1)...
This retrospective study was an investigation of overall survival (OS), disease-free (DFS) and prognostic factors affecting OS DFS in cirrhotic patients who received intraoperative radiofrequency ablation (IORFA).Between April 2009 November 2013, 112 (94 men, 84%; 18 women, 16%) underwent IORFA for 185 cases hepatocellular carcinomas (HCC). Repeat done 9 during the same period (total 121 treatments).All were followed-up at least 12 months (mean follow-up, 32 months). Surgical resection...
Abstract We conducted a retrospective study to evaluate the clinical impact of an early recovery posttransplant absolute lymphocyte count (ALC) on outcome frontline autologous stem cell transplantation (ASCT) for diffuse large B‐cell lymphoma (DLBCL). reviewed 65 DLBCL patients who underwent ASCT after primary chemotherapy based cyclophosphamide, doxorubicin, vincristine, and prednisone. A receiver operating characteristic analysis was performed determine optimal cut point (0.4 × 10 9 /L)...
Background Interferon-gamma (IFN-γ) is a critical cytokine in the defense against Mycobacterium tuberculosis infection. Even though IFN-γ has occasionally been used treatment of refractory multidrug-resistant (MDR-TB) with some promising results, there still controversy regarding therapeutic efficacy IFN-γ. This study was performed to examine effect subcutaneous MDR-TB patients. Methods Six patients were enrolled this study. Two million IU administered subcutaneously three times week...