A5003126278- Lymphoma Diagnosis and Treatment
- Acute Myeloid Leukemia Research
- CNS Lymphoma Diagnosis and Treatment
- Hematopoietic Stem Cell Transplantation
- Viral-associated cancers and disorders
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Chronic Lymphocytic Leukemia Research
- Multiple Myeloma Research and Treatments
- Retinoids in leukemia and cellular processes
- Histone Deacetylase Inhibitors Research
- Wind and Air Flow Studies
- Autophagy in Disease and Therapy
- Bone and Joint Diseases
- Glioma Diagnosis and Treatment
- MicroRNA in disease regulation
- Building Energy and Comfort Optimization
- Protein Degradation and Inhibitors
- Extracellular vesicles in disease
- Blood disorders and treatments
- T-cell and Retrovirus Studies
- Cancer-related Molecular Pathways
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Hematological disorders and diagnostics
- Microtubule and mitosis dynamics
Yonsei University
2012-2022
Wonju Severance Christian Hospital
2021-2022
Woosong University
2012-2022
Gangnam Severance Hospital
2016-2020
Severance Hospital
2013-2017
Identification of biomarkers that predict responses to hypomethylating agents (HMAs) will allow optimal strategies for epigenetic therapy in myelodysplastic syndromes (MDS) be established. Serum miR-21 was quantitatively measured 58 MDS patients treated with HMAs and 14 healthy controls. miR-192 an internal control, diagnostic performance evaluated according receiver operating characteristics (ROCs). ROC analysis indicated serum levels differentiated responders from non-responders area under...
Isolated myeloid sarcoma (MS) is a rare extramedullary tumor mass composed of malignant precursor cells without any evidence leukemia in the peripheral blood and bone marrow. We describe clinical characteristics outcomes patients diagnosed with isolated MS at our institution.We retrospectively reviewed 9 497 acute (AML) (1.8%) MS. were divided into 2 groups according to first-line treatment strategy: systemic only (S) or local (LS).The most common site occurrence was head neck area (N=4,...
Despite extensive study, the use of allogeneic hematopoietic stem cell transplantation in acute myeloid leukemia (AML) vary considerably. The decision which these options to choose is complex and depends on both clinical molecular variables as well availability histocompatability donor cells. So far there no clear explanation whether expression myeloperoxidase (MPO) relates prognosis AML.We retrospectively analyzed prognostic significance MPO 140 patients with diagnosed AML treated at a...
The modified Glasgow Prognostic Score (mGPS) consisting of serum C-reactive protein and albumin levels, shows significant prognostic value in several types tumors. We evaluated the significance mGPS 285 patients with diffuse large B cell lymphoma (DLBCL), retrospectively.According to classification, 204 (71.5%) had an 0, 57 (20%) 1, 24 (8.5%) 2.Our study found that high were associated poor factors including older age, extranodal involvement, advanced disease stage, unfavorable International...
Autophagy is a lysosomal degradation mechanism that essential for cell survival, differentiation, development, and homeostasis. protects cells from various stresses, including protecting normal harmful metabolic conditions, cancer chemotherapeutics. In the current study, cytarabine arabinoside (Ara‑C)‑sensitive U937 leukemia line an Ara‑C‑resistant (U937/AR) were assessed baseline autophagy activity by investigating LC3‑I conversion to LC3‑II, performing EGFP‑LC3 puncta, acidic...
This study introduces a plan to improve ventilation effectiveness through an appropriate operable window opening area and partitioning/placement promote natural based on unit location elevation. To predict the performance of high-rise building, total 800 rate data were calculated according location, elevation (2.5%, 5.0%, 7.5% 10% floor at 8 locations 25 different elevations) by using network simulation. A CFD-based wind tunnel simulation, 5 alternative cases, was implemented analyze...
Factors for Severe Bacterial Infection in Patients with Multiple Myeloma during Treatment Bortezomib-based RegimensThe aim of this study was to identify the risk factors associated severe bacterial infection (SBI) multiple myeloma (MM) patients treatment bortezomibbased regimens.A total 98 MM were evaluated 427 courses.SBI occurred 57.1% (56/98) and 19.0%(81/427) courses.In multivariate analysis development SBI each course, poor performance status (Eastern Cooperative Oncology Group ≥ 2, P <...
Purpose: Decitabine, a DNA hypomethylating agent, was recently approved for use in Korea older adults with acute myeloid leukemia (AML) who are not candidates standard chemotherapy.This study aimed to evaluate the role of decitabine as firstline treatment AML. Materials and Methods: Twenty-four patients AML received at least one course (20 mg/m 2 /d intravenously 5 days every 4 weeks) first-line therapy Severance Hospital were evaluated retrospectively. Results:The median age 73.5 years.The...
The overexpression of Aurora A kinase (AurA) has been reported in various malignancies, including acute myeloid leukemia (AML). However, the expression AurA and effects inhibition cancer stem cells are not yet fully understood. We investigated AML (CD34(+)/CD38(-)).Expression was cell lines (NB4 KG1) that express high levels CD34 low CD38. Primary were harvested from 8 patients. death induced by analyzed CD34(+)/CD38(-) cells.AurA shown to be overexpressed both primary (LSCs) compared normal...
Few studies have evaluated the risk factors for hepatic sinusoidal obstructive syndrome (SOS) in patients with malignant lymphoma receiving autologous stem cell transplantation (ASCT). We retrospectively analyzed 132 who underwent ASCT. Intravenous busulfan-based conditioning regimens were used 108 (81.8%) patients. The combination of heparin and ursodeoxycholic acid was prophylaxis SOS. Hepatic SOS developed 10 (7.6%) at a median 30 days post-ASCT. In nine (90.0%) patients, diagnosed after...
Background/Aims: Adherence to tyrosine kinase inhibitors (TKIs) has become a critical aspect of care in chronic myeloid leukemia (CML). We aimed examine the association TKI adherence with overall survival (OS) outcomes Korean patients diagnosed CML and treated TKIs using data from National Health Information Database.Methods: This study included 2,870 between 2005 2013. Drug was evaluated according medication possession ratio (MPR) classified as high (i.e., MPR ≥ 0.95 [upper 50%]), moderate...
Upfront autologous stem cell transplantation (ASCT) has shown favourable outcome in patients with primary central nervous system lymphoma (PCNSL), but the role of risk-adapted upfront ASCT consolidation not been evaluated PCNSL. As PCNSL International Extranodal Lymphoma Study Group (IELSG) prognostic score ≥2 or those who did achieve complete response after two courses induction chemotherapy (non-CR1) have inferior outcomes, we retrospectively analysed 66 high-risk (IELSG and/or non-CR1)...
Only a few patients who experience AML relapse derive lasting benefit from re-induction therapy. The utility of reassessing the disease karyotype at is unclear. main goals this study were to identify prognostic factors for and determine karyotypic change between diagnosis as variable predicting response salvage therapy relapsed AML.This retrospective included 58 with treated Yonsei University College Medicine 2005 2010. Karyotypes both available 45 (77%). A in was observed 17 cases (37%), no...
// Yu Ri Kim 1 , Soo-Jeong 2 June-Won Cheong Haerim Chung Ji Eun Jang Yundeok Woo-Ick Yang 3 Yoo Hong Min and Jin Seok Division of Hematology, Department Internal Medicine, Gangnam Severance Hospital, Yonsei University College Seoul 06273, Republic Korea 03722, Pathology, Correspondence to: Kim, email: hemakim@yuhs.ac Keywords: peripheral T-cell lymphoma, Epstein-Barr virus, whole blood, prognostic score Received: July 25, 2017 Accepted: August 23, Published: September ABSTRACT Because there...
Pharmacological inhibition of mutant isocitrate dehydrogenase (IDH) reduces R-2-hydroxyglutarate (2-HG) levels and restores cellular differentiation in vivo vitro. The IDH2 inhibitor enasidenib (AG-221) has been approved by the FDA as a first-in-class for treatment relapsed or refractory (R/R) IDH2-mutant acute myeloid leukemia (AML). In this study, effects combination all-trans retinoic acid (ATRA) AG-221 on AML cell was explored, along with mechanisms employed cells AML.We treated human...