To compare the risk of dementia associated with sodium-glucose cotransporter-2 (SGLT-2) inhibitors versus dipeptidyl peptidase-4 (DPP-4) in adults aged 40-69 years type 2 diabetes.

Joint National Committee guidelines attempt to vary treatment recommendations for patients based on considerations of their comorbidities. The aim the present study is estimate age-standardized prevalence common comorbidities among Korean hypertension patients. We analyzed Korea Health and Nutrition Examination Survey from 2007 2013. Among 58423 participants, 30092 adults, aged ≥30 yrs who completed a health examination interview survey, were selected. survey procedures used weighted odds...

With the high prevalence of gout and associated cardiovascular (CV) diseases, information on comparative CV safety individual urate-lowering drugs becomes increasingly important. However, few studies examined risk uricosuric agents. We compared among patients with who initiated allopurinol vs. benzbromarone.Using Korean National Health Insurance claims data (2002-17), we conducted a cohort study 124 434 either (n = 103 695) or benzbromarone 20 739), matched propensity score at 5:1 ratio. The...

Lay Summary Behçet disease (BD) is a multisystem vasculitis (inflammation of the blood vessels) unknown origin that commonly results in oral and genital ulcers, uveitis (eye inflammation) skin lesions. BD most prevalent people from Mediterranean to East Asia, affecting 0.4% this area. Most lesions go away with time, but more severe forms involve cardiovascular neurological systems can lead death. It estimated have 1.4 times risk dying than general population. Using large insurance databases...

To compare infectious risk between JAK inhibitors (JAKis) versus TNF (TNFis) among rheumatoid arthritis (RA) patients in Korea.

Adolescence is a time of rapid growth with dramatic changes in physical appearance. The body image established at this could affect their and mental health throughout entire life. However, adolescents sometimes perceive themselves as underweight or overweight irrespective actual weight status. purpose the present study was to examine extent misperception for Korean adolescents, explore socio-demographic factors associated misperception, gender-specific differences relationships between...

To compare cardiovascular (CV) risk among gout patients initiating allopurinol vs febuxostat.Using 2002-2015 Korean National Health Insurance Service data for the entire population, we conducted a cohort study on or febuxostat. The primary outcome was composite CV end point of myocardial infarction, stroke/transient ischaemic attack, coronary revascularization. Secondary outcomes were individual components outcome, and all-cause mortality. We used propensity score-matching with 4:1 ratio...

We examined the association between socioeconomic status (SES) and comorbidity distribution among patients with RA.Information on comprehensive health of 1088 RA (weighted n = 612 303) was obtained from 2007-2015 Korea National Health Nutrition Examination Survey database. SES components were household equivalence income, education area residence. To minimize confounding by age, stratified median age (63 years). Age-adjusted odds ratio (OR) 95% confidence interval (95% CI) estimated,...

Abstract Objectives To compare the risk of urolithiasis in gout patients initiating allopurinol, a xanthine oxidase inhibitor, vs benzbromarone, uricosuric. Methods Using 2011–20 Korea National Health Insurance Service database, we conducted cohort study on allopurinol benzbromarone as first-line urate-lowering treatment. The primary outcome was new onset urinary stone. secondary stone requiring intervention. We estimated hazard ratios (HRs) and 95% CIs using Cox proportional models with 5:1...

OBJECTIVE We aim to compare the risk of nephrolithiasis among type 2 diabetes patients who initiated sodium-glucose cotransporter-2 inhibitors (SGLT2is) versus dipeptidyl-peptidase-4 (DPP4is), individually within stone never- and ever-formers. RESEARCH DESIGN AND METHODS Using 2010–2021 Korea National Health Insurance Service database, we conducted a population-based cohort study, comparing initiators SGLT2is DPP4is. The primary outcome was incident nephrolithiasis. Osteoarthritis encounters...

The purpose of this study was to explore risk factors related asthma prevalence among preschool and school-aged children using a representative national dataset from the Korea National Health Nutrition Examination Survey (KNHANES) conducted 2009-2011. We evaluated demographic information, health status, household environment, socioeconomic parents' status 3,542 aged 4-12 years. A sex-stratified multivariate logistic regression used obtain adjusted odds ratios (ORs) 95% confidence intervals...

Abstract Novel immunogenic antigens are continually required for the improvement of diagnostic techniques Mycobacterium tuberculosis infection. Some proteins with serodiagnostic value not expressed under normal culture conditions, but may be induced specific conditions such as gradual oxygen depletion and low pH, from inside macrophages. Using a customized amplification library, we previously found that Rv2041c M. H37Rv was highly in vitro pH hypoxia. In this study, recombinant (r)Rv2041c...

To compare the risk of blindness and vision-threatening ocular comorbidities in patients with Behçet's disease (BD) vs general population.Using 2002-2017 Korea National Health Insurance Service database, we did a population-based cohort study comparing newly diagnosed BD age- sex-matched non-BD controls at 1:5 ratio. The primary outcome was blindness, defined as best-corrected visual acuity ≤20/500 better-seeing eye. Secondary outcomes were (cataract, glaucoma retinal disorders) that require...

Abstract Objectives We aimed to compare tuberculosis (TB) risk during biologics treatment between patients with RA who did (prophylaxis) and not (non-prophylaxis) undergo chemoprophylaxis following pre-biologic latent TB screening in Korea of an intermediate burden. Methods Using the 2002–16 National Health Insurance database, we conducted a cohort study examining risk, defined by International Classification Diseases Tenth Revision codes plus anti-TB drugs, among initiating biologic drug...

To assess pre-biologic treatments with conventional synthetic disease-modifying drugs (csDMARDs) prior to biologics initiation among patients rheumatoid arthritis (RA).Using Korea National Health Insurance database, we examined of RA on the following four items whether 1) initial methotrexate (MTX) therapy was given, 2) MTX dose escalated up ≥15 mg/week within 1-year post-diagnosis, 3) prednisone-equivalent glucocorticoid used at a ≤7.5 mg/day, and 4) discontinued 6 months treatment....

<p dir="ltr"><b>Objective: </b>We aim to<b> </b>compare the risk of nephrolithiasis among type 2 diabetes patients who initiated sodium-glucose cotransporter-2 inhibitors (SGLT2is) versus dipeptidyl-peptidase-4 (DPP4is), individually within stone never- and ever-formers.</p><p dir="ltr"><b>Research Design Methods: </b>Using 2010-2021 Korea National Health Insurance Service database, we conducted a population-based cohort study, comparing...

<p dir="ltr"><b>Objective: </b>We aim to<b> </b>compare the risk of nephrolithiasis among type 2 diabetes patients who initiated sodium-glucose cotransporter-2 inhibitors (SGLT2is) versus dipeptidyl-peptidase-4 (DPP4is), individually within stone never- and ever-formers.</p><p dir="ltr"><b>Research Design Methods: </b>Using 2010-2021 Korea National Health Insurance Service database, we conducted a population-based cohort study, comparing...

<h3>Background</h3> Gout is associated with an increased risk of cardiovascular (CV) disease. <h3>Objectives</h3> We aimed to investigate comparative CV among gout patients who initiated allopurinol versus febuxostat. <h3>Methods</h3> Using the 2002–2015 Korean National Health Insurance Service (KNHIS) data for whole population, we conducted a cohort study on aged ≥40 years had ICD-10 diagnosis code and or febuxostat without prior history urate lowering therapy, excluding those chronic...