The organic cation transporter 1 (OCT1) plays a key role in the cellular transport of metformin and its subsequent glucose-lowering effect. A recent non-clinical study reported that uptake into hepatocytes is regulated via OCT1, was strongly inhibited by verapamil. Therefore, we investigated effects verapamil co-administration on pharmacokinetics pharmacodynamics humans.We evaluated anti-hyperglycaemic using an oral glucose tolerance test (OGTT) 12 healthy participants, before (day 1) after...

We aimed to investigate the association between serum lipid level and tinnitus risk in Korean older adults.

ABSTRACT Granulocyte colony‐stimulating factor (G‐CSF) mobilizes peripheral blood (PB) progenitor cells from bone marrow (BM) into circulation for PB stem cell transplantation (PBSCT). This study aimed to develop a population pharmacokinetic–pharmacodynamic (PK‐PD) model of filgrastim in healthy subjects optimize CD34 + collection. Plasma concentrations and count data were obtained clinical involving Korean subjects. A total 1378 plasma concentration measurements 982 collected 53 used the...

Bepotastine, a second-generation antihistamine for allergic rhinitis and urticaria, is widely used in all age groups but lacks appropriate dosing guidelines pediatric patients, leading to off-label prescriptions. We conducted this study propose an optimal regimen patients based on population pharmacokinetic (popPK) physiologically (PBPK) models using data from two previous trials. A popPK model was built NONMEM software. one-compartment with first-order absorption lag time described our...

Network pharmacology has gained significant traction as a tool for identifying the mechanisms and therapeutic effects of herbal medicines. However, despite usefulness these approaches, their diversity underscores critical need systematic evaluation to ensure consistency reliability.

Given their medical vulnerabilities, we investigated the epidemiological factors related to H1N1 infection in school-aged children.This study analyzed data collected on 7448 children South Korea between 18 November and 8 December 2009.We found that was associated with body mass index (BMI), waist circumference (WC), use of facemasks, contact history H1N1-infected persons, overseas travel (P < 0·05). In addition, WC quartiles were significantly after adjusting for BMI other confounding...

Human multidrug and toxin extrusion member 2 (MATE2-K, SLC47A2) plays an important role in the renal elimination of various clinical drugs including antidiabetic drug metformin. The goal this study was to characterize genetic variants MATE2-K determine their association with pharmacokinetics metformin.We screened DNA samples from 48 healthy Koreans for promoter coding regions examined function common haplotypes region using in-vitro luciferase assays. Then, metformin pharmacokinetic carried...

Nonalcoholic fatty liver disease (NAFLD) and sarcopenia, which are common in elderly men, known as risk factors of fracture. However, few studies have examined the association with fracture these patients. Therefore, we aimed to investigate between NAFLD or without sarcopenia 10-year probability Korean men aged ≥50 years.Data 2,525 individuals from 2010-2011 Korea National Health Nutrition Examination Survey were analyzed. was defined using index (FLI) comprehensive score (CNS), fibrosis 4...

We aimed to investigate the association between daily sunlight exposure duration and fractures in older Korean adults with osteoporosis.We utilized data from 2008-2011 Korea National Health Nutrition Examination Survey. Osteoporosis was diagnosed based on a T-score of ≤-2.5 using dual energy X-ray absorptiometry. The fracture were assessed via intensive health interviews by trained staff standardized questionnaires. Fracture defined as one or more femur, wrist, spine.A total 638 patients...

The edible seaweed Gelidium elegans (GEE) is known to inhibit adipocyte differentiation. However, there has been no report on its effects in humans. In this study, we investigated whether GEE reduces body weight or fat mass obese overweight individuals. A total of 78 participants were randomly assigned the test (GEE extract 1000 mg/day) and placebo groups at a 1:1 ratio, treated for 12 weeks. At six weeks after randomization, they evaluated anthropometric parameters, biomarkers, composition....

Background: Esomeprazole is the most effective treatment for acid-related disorders and widely used with enteric coating due to rapid degradation in acidic environment. However, enteric-coated formulation delays absorption onset of action. To overcome this limitation, an immediate-release containing esomeprazole 20 mg sodium bicarbonate 800 (IR-ESO) was developed. Purpose: evaluate safety, pharmacokinetics (PK), pharmacodynamics IR-ESO compared those (ESO). Methods: A randomized, open-label,...

Abstract Clopidogrel is an antiplatelet drug used to reduce the risk of acute coronary syndrome and stroke. It converted by CYP2C19 its active metabolite; therefore, poor metabolizers (PMs) exhibit diminished effects. Herein, we conducted a proof‐of‐concept study for using population pharmacokinetic‐pharmacodynamic (PK‐PD) modeling recommend personalized clopidogrel dosing regimen individuals with varying phenotypes baseline P2Y12 reaction unit (PRU) levels. Data from prospective phase I...

Alzheimer's disease (AD) is a representative cause of dementia and caused by neuronal loss, leading to the accumulation aberrant neuritic plaques formation neurofibrillary tangles. Oxidative stress involved in impaired clearance amyloid beta (Aβ), Aβ-induced oxidative causes AD inducing Hwangryunhaedok-tang (HHT, Kracie K-09

Izuforant is a selective, and potent histamine H4 receptor (H4R) antagonist developed to treat atopic dermatitis (AD). There an unmet medical need for therapeutic agents control inflammation pruritus. strong candidate this task based on the findings of non-clinical studies showing that inhibition histamine-mediated signaling pathway via H4R by izuforant results in decreased pruritus inflammation. This study aimed evaluate clinical pharmacokinetic (PK) pharmacodynamic (PD) profiles izuforant....

Abstract: To improve cardiovascular outcomes, dyslipidemia in patients with diabetes needs to be treated. Thus, these are likely take glimepiride and rosuvastatin concomitantly. Therefore, this study aimed evaluate the pharmacokinetic (PK) interactions between two drugs healthy males explore effect of SLCO1B1 CYP2C9 polymorphisms on their randomized, open-label crossover studies. Glimepiride was studied part 1 2. Twenty-four participants were randomly assigned each part. All subjects (n=24)...

OBJECTIVES Several studies have found a significant association between the presence of earlobe crease (ELC) and cardiovascular disease (CVD). Brachial-ankle Pulse Wave Velocity (baPWV) is non-invasive useful measure arterial stiffness predicting events mortality. However, few reported relationship ELC baPWV as new stiffness. The purpose this study was to determine whether related in non-diabetic, non-hypertensive, apparently healthy Korean adults. METHODS A cross-sectional conducted on 573...

Pandemic influenza A (H1N1) virus has spread rapidly and prompt diagnosis is needed for successful treatment prevention of transmission. We investigated clinical predictors, validated the use previous criteria with laboratory tests, evaluated H1N1 infection in Korean population.We analyzed evaluation data from outpatient clinics at Severance Hospital Seoul, Korea between November 11 December 5, 2009.This analysis included a total 828 patients. Of these, 372 (44.9%) patients were confirmed by...

This study was designed to assess the pharmacokinetics (PK) and safety of fimasartan, an angiotensin II type 1 receptor blocker, in hepatic impairment patients as compared with healthy subjects. An open-label, single-dose, parallel conducted 6 male volunteers 12 subjects impairment. Healthy were matched dysfunction on basis age, gender, body weight. After a single 120-mg oral administration PK parameters analyzed between groups group. Compared subjects, geometric mean ratio 90% confidence...

This study was designed to determine whether genetic polymorphisms of multidrug-resistant protein 2 (ABCC2), organic anion transporting polypeptide 1B1 (SLCO1B1), and breast cancer resistance (ABCG2) have an effect on olmesartan pharmacokinetics in Korean subjects. Sixty-eight healthy male volunteers who participated previous studies medoxomil (single dose, 20 mg or 40 mg) were enrolled. All subjects analyzed grouped according the genotypes ABCC2, SLCO1B1, ABCG2. The dose-normalized peak...

Atorvastatin and ezetimibe are frequently co-administered to treat patients with dyslipidemia for the purpose of low-density lipoprotein cholesterol control. However, pharmacokinetic (PK) drug interaction between atorvastatin has not been evaluated in Korean population. The aim this study was investigate PK two drugs healthy volunteers. An open-label, randomized, multiple-dose, three-treatment, three-period, Williams design crossover conducted 36 male subjects. During each period, subjects...

Evogliptin (DA-1229), a novel dipeptidyl peptidase (DPP)-4 inhibitor with high potency and selectivity, was approved in Korea for the treatment of type 2 diabetes. Preclinical studies suggest that it is metabolized by cytochrome (CYP) P450 isozymes. Based on these findings, clinical study designed to investigate pharmacokinetic (PK) interaction evogliptin CYP inhibitor, clarithromycin.An open-label, two-phase, crossover conducted 12 healthy subjects. On day 1, single dose 5 mg administered...