A5059467318- Multiple Sclerosis Research Studies
- Peripheral Neuropathies and Disorders
- Systemic Lupus Erythematosus Research
- Neuroinflammation and Neurodegeneration Mechanisms
- Autoimmune Neurological Disorders and Treatments
- Immunotherapy and Immune Responses
- CNS Lymphoma Diagnosis and Treatment
- Cytokine Signaling Pathways and Interactions
- Neurogenesis and neuroplasticity mechanisms
- Ocular Diseases and Behçet’s Syndrome
- Psoriasis: Treatment and Pathogenesis
- Extracellular vesicles in disease
- Rheumatoid Arthritis Research and Therapies
- T-cell and B-cell Immunology
- Gut microbiota and health
- Protein Tyrosine Phosphatases
- Long-Term Effects of COVID-19
- RNA regulation and disease
- Circular RNAs in diseases
- Mycobacterium research and diagnosis
- interferon and immune responses
- Neurological Disease Mechanisms and Treatments
- Lung Cancer Research Studies
- MicroRNA in disease regulation
- Immune cells in cancer
Third Affiliated Hospital of Sun Yat-sen University
2016-2025
Sun Yat-sen University
2016-2025
AbbVie (United States)
2019-2025
Anhui University of Traditional Chinese Medicine
2024
Yahoo (United Kingdom)
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2020-2024
Huzhou Central Hospital
2012-2024
First Hospital of Jilin University
2018-2024
Jilin University
2018-2024
Peking Union Medical College Hospital
2020-2024
The aim was to describe the clinical, radiological and pathological features of an autoimmune glial fibrillary acidic protein (GFAP) astrocytopathy.Data from 19 patients with positive GFAP-immunoglobulin G in cerebrospinal fluid (CSF) were retrospectively analyzed.The main disease manifestations included myelitis (68.4%), headache (63.2%), abnormal vision fever (52.6%), ataxia (36.8%), psychosis (31.6%), dyskinesia (15.8%), dementia (15.8%) seizure (10.5%). Seventeen had brain abnormalities...
Preserving the integrity of blood-brain barrier (BBB) is beneficial to avoid further brain damage after acute ischemic stroke (AIS). Astrocytes, an important component BBB, promote BBB breakdown in subjects with AIS by secreting inflammatory factors. The glucagon-like peptide-1 receptor (GLP-1R) agonist exendin-4 (Ex-4) protects and reduces inflammation from cerebral ischemia, GLP-1R expressed on astrocytes. However, effect Ex-4 astrocytes remains unclear.In present study, we investigated...
Disease-modifying drugs (DMDs) may alter the immune status and thus increase susceptibility to coronavirus disease 2019 (COVID-19) in patients with MS or neuromyelitis optica spectrum disorders (NMOSD). However, evidence supporting this notion is currently lacking. In study, we conducted a survey on risk of COVID-19 NMOSD.The was through Chinese Medical Network for Neuroinflammation. Patients 10 centers from 8 cities including Wuhan were included. Information about NMOSD duration usage DMDs...
Rationale: Mesenchymal stromal cells (MSCs) are emerging as a novel therapeutic strategy for the acute ischemic stroke (AIS).However, poor targeted migration and low engraftment in lesions restrict their treatment efficacy.The brain express specific chemokine profile, while cultured MSCs lack set of corresponding receptors.Thus, we hypothesize that overexpression certain receptor might help homing improve efficacy.Methods: Using middle cerebral artery occlusion (MCAO) model stroke,...
Metformin, the first-line therapy for type 2 diabetes (T2D), decreases hepatic glucose production and reduces fasting plasma levels. Dorzagliatin, a dual-acting orally bioavailable glucokinase activator targeting both pancreas liver glucokinase, postprandial in patients with T2D. In this randomized, double-blind, placebo-controlled phase 3 trial, efficacy safety of dorzagliatin as an add-on to metformin were assessed T2D who had inadequate glycemic control using alone. Eligible (n = 767)...
Proper termination of cell-death-induced neural inflammation is the premise tissue repair in acute ischemic stroke (AIS). Macrophages scavenge cell corpses/debris and produce inflammatory mediators that orchestrate immune responses. Here, we report FOXP3, key immune-repressive transcription factor Tregs, conditionally expressed macrophages lesion. FOXP3 ablation results detrimental outcomes, emphasizing beneficial role FOXP3+ macrophages. are distinct from M1 or M2 subsets display...
Abstract Accumulation of amyloid beta protein (Aβ) in brain vessels damages blood barrier (BBB) integrity cerebral angiopathy (CAA). Macrophage lineage cells scavenge Aβ and produce disease-modifying mediators. Herein, we report that Aβ40-induced macrophage-derived migrasomes are sticky to skin biopsy samples from CAA patients tissue mouse models (Tg-SwDI/B 5xFAD mice). We show CD5L is packed docked vessels, enrichment impairs the resistance complement activation. Increased...
Mazdutide is a once-weekly glucagon-like peptide-1 (GLP-1) and glucagon receptor dual agonist. We evaluated the efficacy safety of 24-week treatment mazdutide up to 6 mg in Chinese overweight adults or with obesity, as an interim analysis randomised, two-part (low doses high dose 9 mg), double-blind, placebo-controlled phase 2 trial (ClinicalTrials.gov, NCT04904913). Overweight (body-mass index [BMI] ≥24 kg/m
Cognitive impairment has been associated with an age-related decline in adult hippocampal neurogenesis (AHN). The molecular basis of declining the aging hippocampus remains to be elucidated. Here, we show that pleiotrophin (PTN) expression is decreased neural stem and progenitor cells (NSPCs). Mice lacking PTN exhibit impaired AHN accompanied by poor learning memory. Mechanistically, find engages protein tyrosine phosphatase receptor type Z1 (PTPRZ1) promote NSPC proliferation...
Chitinase-3–like protein 1 (CHI3L1) is primarily secreted by activated astrocytes in the brain and known as a reliable biomarker for inflammatory central nervous system (CNS) conditions such neurodegeneration autoimmune disorders like neuromyelitis optica (NMO). NMO an astrocyte disease caused autoantibodies targeting astroglial aquaporin 4 (AQP4) leads to vision loss, motor deficits, cognitive decline. In this study examining CHI3L1’s biological function neuroinflammation, we found that...
This study aimed to investigate the clinical efficacy and safety of telitacicept in patients with generalized myasthenia gravis (gMG) who tested positive for acetylcholine receptor antibodies or muscle-specific kinase were receiving standard-of-care therapy.
Background The link between Gut microbiota (GM) and Gallstone disease (GSD) is well established, but it not clear whether there a causal relationship the two associations. Methods We conducted bidirectional Mendelian randomization (MR) analyses, leveraging aggregated data from Genome-Wide Association Study (GWAS) of GM Circulating Metabolites. Our primary objective was to investigate interplay intestinal flora GSD. Additionally, we performed mediational two-step MR, multivariate MR uncover...
Exploratory analyses of data pertaining to pharmacokinetic, pharmacodynamic, and disease progression are often referred as the pharmacometrics (PM) analyses. The objective current report is assess role PM, at Food Drug Administration (FDA), in drug approval labeling decisions. We surveyed impact PM on New Applications (NDAs) reviewed over 15 months 2005-2006. survey focused both decisions through four perspectives: clinical pharmacology primary reviewer, their team leader, member, reviewer....