A5047636176- Microbial Natural Products and Biosynthesis
- Marine Sponges and Natural Products
- Fungal Biology and Applications
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- DNA Repair Mechanisms
- Legionella and Acanthamoeba research
- Protein Tyrosine Phosphatases
- Fungal and yeast genetics research
- Bioactive Compounds and Antitumor Agents
- Gut microbiota and health
- Vibrio bacteria research studies
- Diet and metabolism studies
- Mitochondrial Function and Pathology
- Genomics and Phylogenetic Studies
- Plant-Microbe Interactions and Immunity
- Biochemical and Molecular Research
- Crystallography and molecular interactions
- RNA modifications and cancer
- Bacterial biofilms and quorum sensing
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Microbial Community Ecology and Physiology
- RNA and protein synthesis mechanisms
- Cell death mechanisms and regulation
- Bacterial Genetics and Biotechnology
Sun Yat-sen University
2015-2024
South China Agricultural University
2024
Ministry of Education of the People's Republic of China
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
1998-2022
Peking Union Medical College Hospital
1998-2022
Bridge University
2022
Zhongkai University of Agriculture and Engineering
2022
State Council of the People's Republic of China
2018
South China Normal University
2013-2017
Sun Yat-sen University Cancer Center
2017
The gut bacterium
A high-fat diet (HFD) is a high-risk factor for the malignant progression of cancers through disruption intestinal microbiota. However, role HFD-related gut microbiota in cancer development remains unclear. This study found that obesity and obesity-related were associated with poor prognosis advanced clinicopathological status female patients breast cancer. To investigate impact HFD-associated on progression, we established various models, including HFD feeding, fecal transplantation,...
Four new norsesquiterpene peroxides, named talaperoxides A–D (1–4), as well one known analogue, steperoxide B (5, or merulin A), have been isolated from a mangrove endophytic fungus, Talaromyces flavus. Their structures were elucidated mainly by 1D and 2D NMR. Structures of 1, 2, 5 further confirmed single-crystal X-ray diffraction, their absolute configurations also determined using copper radiation. Cytotoxic activities compounds 1–5 evaluated in vitro against human cancer cell lines...
The objective of this study was to screen for novel quorum-sensing inhibitors (QSIs) from traditional Chinese medicines (TCMs) that inhibit bacterial biofilm formation. Six 46 active components found in TCMs were identified as putative QSIs based on molecular docking studies. Of these, three compounds inhibited formation by Pseudomonas aeruginosa and Stenotrophomonas maltophilia at a concentration 200 µM. A fourth compound (emodin) significantly 20 µM induced proteolysis the signal receptor...
Asperterpenoid A (1), a novel sesterterpenoid with new carbon skeleton, has been isolated from mangrove endophytic fungus Aspergillus sp. 16-5c. Its structure was characterized by extensive spectroscopic methods, and the absolute configuration determined single crystal X-ray diffraction analysis. (1) exhibited strong inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase B (mPTPB) an IC50 value of 2.2 μM.
Two new sesterterpenoids, aspterpenacids A (1) and B (2), with an unusual carbon skeleton of a 5/3/7/6/5 ring system were isolated from the mangrove endophytic fungus Aspergillus terreus H010. Their structures elucidated on basis spectroscopic methods, single-crystal X-ray diffraction analysis, electronic circular dichroism calculations. biogenetic pathway for 1 2 is proposed. Both showed no significant antibacterial activity or cytotoxicity at 50 μM.
Six new isocoumarins, compounds<bold>1–4</bold>and<bold>14–15</bold>, two benzofurans,<bold>16–17</bold>, along with nine known isocoumarin analogues,<bold>5–13</bold>were obtained from the mangrove endophytic fungus<italic>Talaromyces amestolkiae</italic>YX1.
Two new chlorinated preussomerins, chloropreussomerins A and B (1 2), together with nine known preussomerin analogues, 3–11, were obtained from the endophytic fungus Lasiodiplodia theobromae ZJ-HQ1. Their structures elucidated by a combination of spectroscopic analyses. The absolute configurations 1 2 both determined single-crystal X-ray diffraction using Cu Kα radiation. Chloropreussomerins 2) are first compounds in family, M (3) is reported for time as natural product. Compounds showed...
Through a computer search of the genome yeast Saccharomyces cerevisiae, coding sequences seven different box C/D antisense small nucleolar RNAs (snoRNAs) with structural hallmarks guides for rRNA ribose methylation have been detected clustered over 1.4-kb tract in an inter-open reading frame region chromosome XIII. The corresponding snoRNAs positively identified cells. Disruption nonessential snoRNA gene cluster specifically suppressed cognate methylations but did not result any growth delay...
Eight secondary metabolites, including three new azaphilones (chermesinones A–C, 1–3), p-terphenyls (6′-O-desmethylterphenyllin, 4; 3-hydroxy-6′-O-desmethylterphenyllin, 5; 3′′-deoxy-6′-O-desmethylcandidusin B, 7), and two known (6, 8), were isolated from the culture of mangrove endophytic fungus Penicillium chermesinum (ZH4-E2). Their structures established by spectroscopic analysis. The absolute configuration 1 was determined X-ray crystallography. Terphenyls 4, 5, 6 exhibited strong...
Three new bianthraquinone derivatives, alterporriol K (1), L (2) and M (3), along with six known compounds were obtained from extracts of the endophytic fungus Alternaria sp. ZJ9-6B, isolated mangrove Aegiceras corniculatum collected in South China Sea. Their structures elucidated by one- two-dimensional NMR spectroscopy, MS data analysis circular dichroism measurements. Compounds 1, 2 3 first alterporriols a C-2–C-2′ linkage. The crystallographic tetrahydroaltersolanol B (7) was reported...
Asperterpenol A (1) and asperterpenol B (2), two novel sesterterpenoids with an unusual 5/8/6/6 tetracyclic ring skeleton, were isolated from a mangrove endophytic fungus Aspergillus sp. 085242. The structures elucidated on the basis of spectroscopic methods absolute configurations determined by single-crystal X-ray diffraction analysis. Compounds 1 2 inhibit acetylcholinesterase IC50 values 2.3 3.0 μM, respectively.
Five new compounds, pinazaphilones A and B (1, 2), two phenolic compounds (4, 5), penicidone D (6), together with the known Sch 1385568 (3), (±)-penifupyrone (7), 3-O-methylfunicone (8), 5-methylbenzene-1,3-diol (9), 2,4-dihydroxy-6-methylbenzoic acid (10) were obtained from culture of endophytic fungus Penicillium sp. HN29-3B1, which was isolated a fresh branch mangrove plant Cerbera manghas collected South China Sea. Their structures determined by analysis 1D 2D NMR mass spectroscopic...
Diaporisoindoles A (1) and B (2), two novel isoprenylisoindole alkaloids, an unusual diisoprenylisoindole dimer diaporisoindole C (3), together with a precursor tenellone (4) were all isolated from the endophytic fungus Diaporthe sp. SYSU-HQ3. The absolute configurations of 1–4 elucidated by spectroscopic analysis, X-ray diffraction, quantum chemical calculations. Diaporisoindole exhibited inhibitory activity against Mycobacterium tuberculosis protein tyrosine phosphatase IC50 values 4.2 5.2 μM.
A pair of unusual benzannulated 6,6-spiroketal enantiomers [(−)-1 and (+)-1] three new biogenetically related compounds (2–4), together with two known analogues (5 6), have been isolated from a mangrove fungus, Penicillium dipodomyicola HN4-3A. Their structures were elucidated on the basis spectroscopic analysis (1D 2D NMR data) X-ray crystallography. The absolute configurations (−)-1 (+)-1 determined using quantum chemical calculations electronic circular dichroic (ECD) spectra. Compounds 2...
Abstract Radiation proctopathy (RP) is a common complication of radiotherapy for pelvic malignancies with high incidence. RP accompanies by microbial dysbiosis. However, how the gut microbiota affects disease remains unclear. Here, metabolomics reveals that fecal and serous concentrations microbiota‐derived 3‐hydroxybutyrate (3HB) are significantly reduced in mice radiotherapeutic patients. Moreover, concentration 3HB negatively associated expression proinflammatory IL6 increased along...
Four new polyketides: nectriacids A-C (1-3) and 12-epicitreoisocoumarinol (4), together with three known compounds: citreoisocoumarinol (5), citreoisocoumarin (6), macrocarpon C (7) were isolated from the culture of endophytic fungus Nectria sp. HN001, which was a fresh branch mangrove plant Sonneratia ovata collected South China Sea. Their structures determined by detailed analysis NMR mass spectroscopic data. The absolute configuration stereogenic carbons for compound 4 further assigned...
Background: Intestinal microbiota is an important environmental factor in the initiation and progression of autoimmune diseases. However, investigations on gut microbiome neuromyelitis optica spectrum disorders (NMOSD) are relatively insufficient, especially for that Asia population. Objectives: To evaluate whether or not intestinal NMOSD patients had specific microbial signatures. Methods: Next-generation sequencing gas chromatography were employed to compare fecal composition short-chain...
The destructive bacterial pathogen Ralstonia solanacearum delivers effector proteins via a type-III secretion system for its pathogenesis of plant hosts. However, the biochemical functions most these effectors remain unclear. RipAK R. GMI1000 is with unknown functions. Functional analysis demonstrated that in tobacco leaves, ripAK knockout bacteria produced an obvious hypersensitive response; also, infected tissues accumulated reactive oxygen species shorter period postinfection, compared...
Lasiodiplactone A (1), an unprecedented lactone, was obtained from the mangrove endophytic fungus Lasiodiplodia theobromae ZJ-HQ1. The structure of 1 established by analysis NMR spectroscopic data and electronic circular dichroism (ECD) spectra. (1) first example lactone that possesses a unique tetracyclic system (12/6/6/5) RAL12 (12-membered β-resorcylic acid lactone) with pyran ring furan ring. possible biogenetic pathway for proposed. Compound showed anti-inflammatory activity inhibiting...