A5101803524- Gut microbiota and health
- RNA Research and Splicing
- Social Media and Politics
- Genomics and Chromatin Dynamics
- Phytoestrogen effects and research
- Gene expression and cancer classification
- Advanced biosensing and bioanalysis techniques
- Estrogen and related hormone effects
- Bioactive natural compounds
- Diet and metabolism studies
- Genetic Mapping and Diversity in Plants and Animals
- Pharmaceutical Practices and Patient Outcomes
- Consumer Behavior in Brand Consumption and Identification
- Analytical Chemistry and Sensors
- Botanical Research and Applications
- Social and Intergroup Psychology
- Genomics, phytochemicals, and oxidative stress
- Gender, Feminism, and Media
- Glutathione Transferases and Polymorphisms
- Chromatin Remodeling and Cancer
- Media Studies and Communication
- Yeasts and Rust Fungi Studies
- Electrical and Thermal Properties of Materials
- Immune Response and Inflammation
- Bioactive Compounds and Antitumor Agents
Wenzhou Medical University
2018-2024
Sun Yat-sen University Cancer Center
2024
Southern Medical University
2024
Sun Yat-sen University
2018-2024
Affiliated Eye Hospital of Wenzhou Medical College
2021-2024
China University of Geosciences
2024
University of Denver
2021-2024
University of Colorado Denver
2021-2024
China Agricultural University
2024
Southwest Medical University
2024
The gut bacterium
A high-fat diet (HFD) is a high-risk factor for the malignant progression of cancers through disruption intestinal microbiota. However, role HFD-related gut microbiota in cancer development remains unclear. This study found that obesity and obesity-related were associated with poor prognosis advanced clinicopathological status female patients breast cancer. To investigate impact HFD-associated on progression, we established various models, including HFD feeding, fecal transplantation,...
Detection of biomarkers in biosystems plays a key role advanced biodiagnostics for research and clinical use. Design new analytical platforms is challenging demand, addressing molecular capture subsequent quantitation. Herein, we developed label-free electrochemical sensor CD44 by ligand-protein interaction. We assembled carbon nanotube composites on the electrode to enhance electronic conductivity 6.2-fold reduce overpotential with shift 77 mV. conjugated hyaluronic acid (HA) surface...
Background: Intestinal microbiota is an important environmental factor in the initiation and progression of autoimmune diseases. However, investigations on gut microbiome neuromyelitis optica spectrum disorders (NMOSD) are relatively insufficient, especially for that Asia population. Objectives: To evaluate whether or not intestinal NMOSD patients had specific microbial signatures. Methods: Next-generation sequencing gas chromatography were employed to compare fecal composition short-chain...
Abstract In recent years, improving work autonomy as an important priority in the UK labour market has been shown to enhance employee mental health and well-being. However, previous theories empirical studies have paid little attention intersectional inequalities benefits of autonomy, preventing us from gaining a comprehensive understanding consequences autonomy. By integrating literature occupational psychology, gender social class, this study develops theoretical hypotheses regarding...
The profession of pharmacy is expanding its involvement in public health, but few studies have examined pharmacists' delivery health services.To assess Iowa and North Dakota practices, frequency service delivery, level achieving the essential services barriers to expansion rural urban areas.This study implemented an on-line survey sent all pharmacists currently practicing Dakota.Overall, 602 valid responses were analyzed, 297 areas 305 areas. Three practice settings (chain stores [169,...
Chromatin Interaction Analysis Using Paired-End Tag Sequencing (ChIA-PET) is an established method to map protein-mediated chromatin interactions. A limitation, however, that it requires a hundred million cells per experiment, which hampers its broad application in biomedical research, particularly studies impractical obtain large number of from rare samples. To reduce the required input cell while retaining high data quality, we developed situ ChIA-PET protocol, as few 1 cells. Here,...
Research focusing on China's media system has mainly discussed the influence of Party media's editorial sectors. This study directs its attention to Party's impact non-editorial sectors Chinese media. Econometric analysis panel data collected from 30 state-owned listed companies (2016–2020) found that involvement in profit-making and image-managing activities improved latter's financial social performance; such effects differ significantly across regions with different marketization levels....
Cohesin is required for chromatin loop formation. However, its precise role in regulating gene transcription remains largely unknown. We investigated the relationship between cohesin and RNA Polymerase II (RNAPII) using single-molecule mapping live-cell imaging methods human cells. Cohesin-mediated transcriptional loops were highly correlated with those of RNAPII followed direction transcription. Depleting RAD21, a subunit cohesin, resulted loss long-range (>100 kb) distal...
The pathogenesis of thyroid-associated orbitopathy (TAO) remains incompletely understand. interaction between immunocytes and orbital fibroblasts (OFs) play a critical role in inflammatory fibrosis. Accumulating reports indicate that significant portion plasma exosomes (Pla-Exos) are derived from immune cells; however, their impact upon OFs function is unclear.
Advanced detection of biomarkers in biofluids plays an important role disease diagnosis and prognosis. Current techniques with pre-labelling suffer from high cost complicated operation, etc. Herein, we designed a label-free electrochemical biosensor for rapid transferrin receptor desirable linear range, sensitivity, specificity, reproducibility, stability practical applications.
Phytoestrogens are selective estrogen receptor modulators (SERMs) with potential for use in hormone replacement therapy (HRT) to relieve peri/postmenopausal symptoms. This study was aimed at elucidating the molecular mechanisms underlying SERM properties of extract Korean-grown Opuntia ficus-indica (KOFI). The KOFI induced response element (ERE)-driven transcription breast and endometrial cancer cell lines expression endogenous estrogen-responsive genes cells. flavonoid content different...
Abstract The objective of this study is to investigate the expression and influence adenosine triphosphate-sensitive potassium channel (KATP) in human umbilical arterial smooth muscle cells (HUASMCs) patients with hypertensive disorders pregnancy (HDP). Western blotting was used detect protein levels KATP inwardly rectifying (Kir)6.1 sulphonylurea receptor (SUR)2B subunits HUASMCs from normal parturients (NP), gestational hypertension (GH), chronic (CH), preeclampsia (PE) superimposed...
Larrea nitida Cav. (LNC), which belongs to the family Zygophyllaceae, is widely indigenous and used in South America treat various pathological conditions. It contains antioxidant antiinflammatory but toxic nordihydroguaiaretic acid (NDGA) as well O ‐methylated metabolite of NDGA (MNDGA) bioactive compounds. The hepatic metabolism‐based toxicological potential extracts LNC (LNE), NDGA, MNDGA has not previously been reported. present study aimed characterize phase I II metabolism reactive...
The electrification of the transportation sector is a pivotal strategy to curb carbon emissions from traditional fossil fuel-powered vehicles. China, world's largest electric vehicle (EV) market, leads this transformative shift. This paper aims unravel past decade's development story EV industry in China. We first provide comprehensive overview trend including analysis market structures, regional variations, technology advancements, and essential infrastructure. then summarize different...
Purpose To explore the pathological mechanism of Toll-like receptor 4 (TLR4) mediating neovascular age-related macular degeneration (nAMD) and potential role TLR4 coreceptor myeloid differentiation protein 2 (MD2).Methods In study, we inhibited MD2 with chalcone derivative L2H17 utilized a laser-induced choroidal neovascularization (CNV) mouse model Tert-butyl hydroperoxide (TBHP)-challenged rhesus choroid-retinal endothelial (RF/6A) cells to assess effect blockade on CNV.Results Inhibiting...