A5106731572- Advanced Graph Neural Networks
- Bioinformatics and Genomic Networks
- Topological and Geometric Data Analysis
- Genomics and Chromatin Dynamics
- Renin-Angiotensin System Studies
- Protease and Inhibitor Mechanisms
- Peptidase Inhibition and Analysis
- Complex Network Analysis Techniques
- Metal and Thin Film Mechanics
- Gene expression and cancer classification
- Sparse and Compressive Sensing Techniques
- Single-cell and spatial transcriptomics
- Cell Image Analysis Techniques
- Domain Adaptation and Few-Shot Learning
- Advanced materials and composites
- Receptor Mechanisms and Signaling
- Evolution and Genetic Dynamics
- Machine Learning and Algorithms
- SARS-CoV-2 and COVID-19 Research
- Heart Failure Treatment and Management
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Face and Expression Recognition
- Hormonal Regulation and Hypertension
Chinese Research Academy of Environmental Sciences
2024-2025
University of Illinois Urbana-Champaign
2018-2024
Nanchang Hangkong University
2022
Cleveland Clinic Lerner College of Medicine
2012-2020
Cleveland Clinic
2011-2013
Soochow University
2012
First Affiliated Hospital of Soochow University
2012
Chinese Academy of Medical Sciences & Peking Union Medical College
2009-2012
Huazhong Agricultural University
2008
Materia (United States)
2006
In many important graph data processing applications the acquired information includes both node features and observations of topology. Graph neural networks (GNNs) are designed to exploit sources evidence but they do not optimally trade-off their utility integrate them in a manner that is also universal. Here, universality refers independence on homophily or heterophily assumptions. We address these issues by introducing new Generalized PageRank (GPR) GNN architecture adaptively learns GPR...
Uromodulin is the most abundant protein in urine. It exclusively produced by renal epithelial cells and it plays key roles kidney function disease. mainly exerts its as an extracellular matrix whose assembly depends on a conserved, specific proteolytic cleavage leading to conformational activation of Zona Pellucida (ZP) polymerisation domain. Through comprehensive approach, including extensive characterisation uromodulin processing cellular models knock-out mice, we demonstrate that...
Corin is a cardiac membrane protease that activates natriuretic peptides. It unknown how corin function regulated. Recently, soluble was detected in human plasma, suggesting may be shed from cardiomyocytes. Here we examined production and activity determined the proteolytic enzymes responsible for cleavage. We expressed HEK 293 cells three fragments of ∼180, ∼160, ∼100 kDa, respectively, cultured medium by Western blot analysis. All were derived activated molecules. Similar results obtained...
Blacks represent a high-risk population for salt-sensitive hypertension and heart disease, but the underlying mechanism remains unclear. Corin is cardiac protease that regulates blood pressure by activating natriuretic peptides. A corin gene variant (T555I/Q568P) was identified in blacks with hypertrophy. In this study, we tested hypothesis contributes to hypertensive hypertrophic phenotype vivo. Transgenic mice were generated express wild-type (WT) or T555I/Q568P under control of α-myosin...
Significance Hepsin is a cell membrane-bound enzyme discovered in the human liver. To date, function of hepsin body remains unclear. Here we show that increases glycogen and lipid production liver lowers metabolic rates adipose tissue browning mice. This medicated by activation hepatocyte growth factor downstream Met signaling both hepatocytes adipocytes. Hepsin-deficient mice are resistant to obesity, hyperglycemia, hyperlipidemia caused high-fat diet or leptin receptor deficiency. Our...
Corin is a membrane-bound protease essential for activating natriuretic peptides and regulating blood pressure. Human corin has 19 predicted N-glycosylation sites in its extracellular domains. It been shown that N-glycans are required cell surface expression zymogen activation. remains unknown, however, how at different may regulate biosynthesis processing. In this study, we examined mutants, which each of the was mutated individually. By Western analysis proteins lysate conditioned medium...
Hypergraphs are used to model higher-order interactions amongst agents and there exist many practically relevant instances of hypergraph datasets. To enable efficient processing hypergraph-structured data, several neural network platforms have been proposed for learning properties structure, with a special focus on node classification. However, almost all existing methods use heuristic propagation rules offer suboptimal performance We propose AllSet, new paradigm that represents highly...
Cohesin is required for chromatin loop formation. However, its precise role in regulating gene transcription remains largely unknown. We investigated the relationship between cohesin and RNA Polymerase II (RNAPII) using single-molecule mapping live-cell imaging methods human cells. Cohesin-mediated transcriptional loops were highly correlated with those of RNAPII followed direction transcription. Depleting RAD21, a subunit cohesin, resulted loss long-range (>100 kb) distal...
We report the synthesis of bioinspired liposomal thrombomodulin (TM) conjugates by chemoselective and site-specific conjugation recombinant TM at C-terminus. is an endothelial cell membrane protein that acts as a major cofactor in C anticoagulant pathway. To closely mimic structural features TM, we proposed membrane-mimetic re-expression onto liposome. A containing EGF-like 456 domains azidohomoalanine C-terminus was expressed E. coli. Conjugation liposome via Staudinger ligation copper-free...
A disintegrin and metalloprotease with thrombospondin type I motifs-1 (ADAMTS1) plays a crucial role in inflammatory joint diseases its inhibitors are potential candidates for anti-arthritis drugs. For the purposes of drug discovery, we reported development validation fluorescence resonance energy transfer (FRET) assay high-throughput screening (HTS) ADAMTS1 inhibitors. FRET substrate was designed quantitative activity enzyme kinetics studies. The developed into 50-µL, 384-well format high...
Generative graph models create instances of graphs that mimic the properties real-world networks. are successful at retaining pairwise associations in underlying networks but often fail to capture higher-order connectivity patterns known as network motifs. Different types contain different motifs, an example which triangles arise social and biological It is hence vital these structures simulate accurately. We propose Multi-MotifGAN (MMGAN), a motif-targeted Adversarial Network (GAN)...
Rho-kinase has been suggested as a potential therapeutic target in the treatment of cardiovascular diseases. The signaling pathway is substantially involved vascular contraction. aim present study was to evaluate vasorelaxant effects Rho kinase inhibitor DL0805 isolated rat aortic rings and investigate its possible mechanism(s). It found that exerted vasorelaxation dose-dependent manner NE or KCl-induced sustained contraction partial loss under endothelium-denuded rings. DL0805-induced...
Abstract Single-cell RNA-Sequencing has the potential to provide deep biological insights by revealing complex regulatory interactions across diverse cell phenotypes at single-cell resolution. However, current gene network inference methods produce a single per input dataset, limiting their capability uncover relationships related phenotypes. We present SimiC, framework that overcomes this limitation jointly inferring distinct, but related, dynamics phenotype. show SimiC uncovers key missed...