A5028189495- BRCA gene mutations in cancer
- Nutrition, Genetics, and Disease
- Bioinformatics and Genomic Networks
- Genomics and Rare Diseases
- Genetics, Bioinformatics, and Biomedical Research
- Pharmacological Effects of Natural Compounds
- Genetic Associations and Epidemiology
- Molecular Biology Techniques and Applications
- Cancer Cells and Metastasis
- Immune cells in cancer
- Nutritional Studies and Diet
- Polysaccharides and Plant Cell Walls
- CAR-T cell therapy research
- DNA Repair Mechanisms
- Nitric Oxide and Endothelin Effects
- Sulfur Compounds in Biology
- Vitamin D Research Studies
- Mycobacterium research and diagnosis
- Mast cells and histamine
- Cancer Immunotherapy and Biomarkers
- NF-κB Signaling Pathways
- Epigenetics and DNA Methylation
- Single-cell and spatial transcriptomics
- Diet and metabolism studies
- Ferroptosis and cancer prognosis
Harvard University
2023-2024
Southern Medical University
2024
Second Affiliated Hospital of Nanchang University
2024
Zhujiang Hospital
2024
Nanchang University
2024
Czech Academy of Sciences
2023
Czech Academy of Sciences, Institute of Molecular Genetics
2023
National Cancer Centre Singapore
2023
Charles University
2023
General University Hospital in Prague
2023
AIM:To explore probable mechanism underlying the therapeutic effect of Astragalus polysaccharide (APS) against experimental colitis. METHODS:Thirty-two Sprague-Dawley rats were randomly divided into four groups.Colitis was induced with 2, 4, 6-trinitrobenzene sulfonic acid (TNBS).The colitis treated 400 mg/kg APS for 7 d.The evaluated by colonic weight, weight index colon, length, and macroscopic histological scores.The levels regulatory T (Treg) cells in Peyer's patches measured flow...
The present study explored the feasible pathway of Si Shen Wan (SSW) in inhibiting apoptosis intestinal epithelial cells (IECs) by observing activation phospholipase Cγ-1 (PLC-γ1) and PI3K/Akt signal colonic mucosa from rats with colitis. Experimental colitis was induced 2,4,6-trinitrobenzene sulfonic acid (TNBS) Sprague-Dawley rats. After SSW administrated for 7 days after TNBS infusion, western blot showed an increment levels PI3K, p-Akt, IL-23 a decrement PLC-γ1 HSP70 mucosal injury TNBS....
The aim of the present study was to explore functional mechanism NF-Kappa B-interacting Long non-protein coding RNA (NKILA) in breast malignant phyllodes tumors (BMPTs). expression and role NKILA were investigated by performing qRT‒PCR, Transwell assays, CCK‒8 assays primary BMPT cells. A Kaplan‒Meier curve used assess overall survival (OS) local recurrence-free (LRFS). location levels P65 determined fluorescence situ hybridization (FISH) immunofluorescence (IF), respectively. downregulated...
Abstract Background: Breast cancer has been associated with monogenic, polygenic, and epidemiologic (clinical, reproductive lifestyle) risk factors, but studies evaluating the combined effects of these factors have limited. Methods: We extended previous work in breast modeling, incorporating pathogenic variants (PV) six predisposition genes a 105-SNP polygenic score (PRS), to include an (ERS) sample non-Hispanic White women drawn from prospective cohorts population-based case-control...
Abstract Importance Pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2 , and PALB2 are associated with increased breast cancer risk. However, it is unknown whether risk differs by PV type or location carriers ascertained from the general population. Objective To evaluate risks . Design Age adjusted case-control association analysis for all participants, subsets of carriers, women no family history population-based clinical testing cohorts. Setting Twelve US studies within Cancer Risk...
<p>Supplementary Figure S2 shows predicted 5-year risks of breast cancer based on carrier status, PRS, and ERS</p>
<div>AbstractBackground:<p>Breast cancer has been associated with monogenic, polygenic, and epidemiologic (clinical, reproductive, lifestyle) risk factors, but studies evaluating the combined effects of these factors have limited.</p>Methods:<p>We extended previous work in breast modeling, incorporating pathogenic variants (PV) six predisposition genes a 105-SNP polygenic score (PRS), to include an (ERS) sample non-Hispanic White women drawn from prospective cohorts...
<p>Supplementary Figure S1 shows predicted lifetime risks of breast cancer based on carrier status and PRS, without with ERS</p>
Background . In the context of hepatocellular carcinoma (HCC), tumor-associated macrophages (TAMs) are pivotal for immunosuppressive nature tumor microenvironment (TME). This investigation delves into functional transformations TAMs within TME by leveraging single-cell transcriptomics to pinpoint critical genes influencing TAM subset polarization. Methods We procured and bulk transcriptomic data from Gene Expression Omnibus (GEO) The Cancer Genome Atlas (TCGA), implementing quality...