A5101643642- Multiple Sclerosis Research Studies
- Plant-Microbe Interactions and Immunity
- Immunotherapy and Immune Responses
- Systemic Lupus Erythematosus Research
- Peripheral Neuropathies and Disorders
- Gut microbiota and health
- Psoriasis: Treatment and Pathogenesis
- Dermatology and Skin Diseases
- Legume Nitrogen Fixing Symbiosis
- Immune Cell Function and Interaction
- Advanced Glycation End Products research
- Plant Pathogens and Resistance
- Plant Pathogens and Fungal Diseases
- Spine and Intervertebral Disc Pathology
- NF-κB Signaling Pathways
- Cancer Immunotherapy and Biomarkers
- Genomics and Phylogenetic Studies
- IL-33, ST2, and ILC Pathways
- Neuroinflammation and Neurodegeneration Mechanisms
- Probiotics and Fermented Foods
- Inflammasome and immune disorders
- Forest Management and Policy
- Immune Response and Inflammation
- Vector-borne infectious diseases
- Shoulder Injury and Treatment
Zhujiang Hospital
2024
Southern Medical University
2024
Sichuan University
2020-2024
Shanghai Academy of Agricultural Sciences
2022-2024
Northwest A&F University
2024
State Key Laboratory of Biotherapy
2020-2024
Tongren Hospital
2024
Shanghai Ninth People's Hospital
2021-2024
University of Toronto
2024
China Pharmaceutical University
2024
Abstract The intestinal microbiota has been associated with host immunity as well psoriasis; however, the mechanism of regulating psoriasis needs to be demonstrated systematically. Here, we sought examine its role and action in pathogenesis psoriasis. We found that severity psoriasis-like skin phenotype was accompanied by changes composition microbiota. performed co-housing fecal microbial transplantation (FMT) experiments using K14-VEGF transgenic mouse model transfer from mice severe...
The precise mechanism through which macroautophagy/autophagy affects psoriasis is poorly understood. Here, we found that keratinocyte (KC) autophagy, was positively correlated with psoriatic severity in patients and mouse models could be inhibited by mitogen-activated protein kinase (MAPK) family inactivation. impairment of autophagic flux alleviated psoriasisform inflammation. We also an autophagy-based unconventional secretory pathway (autosecretion) dependent on ATG5 (autophagy related 5)...
Abstract Tumor-secreted factors contribute to the development of a microenvironment that facilitates escape cancer cells from immunotherapy. In this study, we conduct retrospective comparison proteins secreted by hepatocellular carcinoma (HCC) in responders and non-responders among cohort ten patients who received Nivolumab (anti-PD-1 antibody). Our findings indicate have high abundance RNase1, which is associated with poor prognosis various types. Furthermore, mice implanted HCC overexpress...
Abstract Purpose Plant growth–promoting (PGP) bacteria are an environment-friendly alternative to chemical fertilizers for promoting plant growth and development. We isolated characterized a PGP endophyte, YSD YN2, from the leaves of Cyperus esculentus L. var. sativus . Methods Specific characteristics this strain, such as phosphate solubilization ability, potassium-dissolving siderophore indole-3-acetic acid (IAA) production, salt tolerance, were determined in vitro. In addition, positive...
Objective To evaluate the efficacy and safety of low-dose mycophenolate mofetil (MMF,1000 mg/day) treatment neuromyelitis optica spectrum disorders (NMOSDs). Methods This study was a multicenter, open, prospective, follow-up clinical trial. The data include retrospective from pretreatment phase prospective posttreatment phase. From September 2014 to February 2017, NMOSD patients seropositive for aquaporin 4-IgG (AQP4-IgG) were treated with MMF. Results Ninety MMF median duration 18 months...
Abstract Interleukin-37b (hereafter called IL-37) was identified as fundamental inhibitor of natural and acquired immunity. The molecular mechanism function IL-37 in colorectal cancer (CRC) has been elusive. Here, we found that transgenic (IL-37tg) mice were highly susceptible to colitis-associated (CAC) suffered from dramatically increased tumor burdens colon. Nevertheless, is dispensable for intestinal mutagenesis, CRC cell proliferation, apoptosis, migration. Notably, dampened protective...
Background: Myelin oligodendrocyte glycoprotein (MOG) antibody associated encephalomyelitis is increasingly being considered a distinct disease entity, with seizures and encephalopathy commonly reported. We investigated the clinical features of MOG-IgG positive patients presenting and/or in single cohort. Methods: Consecutive suspected idiopathic inflammatory demyelinating diseases were recruited from tertiary University hospital Guangdong province, China. Subjects seropositivity analyzed...
The pathogenesis of Intervertebral Disc Degeneration (IDD) is complex and multifactorial, with cellular senescence nucleus pulposus (NP) cells inflammation playing major roles in the progression IDD.The stimulator interferon genes (STING) axis a key mediator during infection, stress, tissue damage.Here, we present progressive increase STING senescent NP degradation disorder.The function normal can prevent IDD.However, dysfunction through autophagy causes accumulation high expression as well...
The aim of this study was to analyse the clinical and prognostic features myelin oligodendrocyte glycoprotein (MOG) antibody-associated demyelination with different onset phenotypes.A total 52 MOG-IgG-seropositive patients were divided into four groups: (i) optic neuritis (ON) at (MOG-ON+ , n = 23), (ii) transverse myelitis (TM) (MOG-TM+ 12), (iii) pure brain symptoms (MOG-ON- -TM- 14) (iv) both ON TM (n 3). This final group not included in further analyses. Data collected through medical...
Anthracnose disease caused by Colletotrichum gloeosporioides is one of the devastating diseases yams (Dioscorea sp.) worldwide. In this study, we aimed to isolate endophytic actinobacteria from yam plants and evaluate their potential for control anthracnose based on bioassays genomic analyses. A total 116 actinomycete strains were isolated surface-sterilized tissues a orchard in Hainan Province, China. total, 23 isolates showed antagonistic activity against C. gloeosporioides. An...
Abstract Background Lower back pain is often accredited to loss of intervertebral disc (IVD) height and compromised spine stability as a result degeneration (IVDD). We aim locally use bleomycin induce the fibrotic transformation bone marrow stromal cells (BMSCs) means reparative fibrosis slow down loss. Methods IVDs from patients were gathered for histological examination. The expression transforming growth factor beta 1 (TGF-β) signaling pathway was determined by qPCR western blotting....