A5103213607- Ferroptosis and cancer prognosis
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Immunotherapy and Immune Responses
- Lung Cancer Research Studies
The First Affiliated Hospital, Sun Yat-sen University
2024
Sun Yat-sen University
2024
Abstract Tumor-secreted factors contribute to the development of a microenvironment that facilitates escape cancer cells from immunotherapy. In this study, we conduct retrospective comparison proteins secreted by hepatocellular carcinoma (HCC) in responders and non-responders among cohort ten patients who received Nivolumab (anti-PD-1 antibody). Our findings indicate have high abundance RNase1, which is associated with poor prognosis various types. Furthermore, mice implanted HCC overexpress...
<h3>Background</h3> Ribonucleases (RNases) are secreted in the circulatory system and reported to mediate physiologically pathologically relevant cellular events, including cancer cell growth, stemness, regenerative capabilities. However, little is known about regulation function of RNases tumor microenvironment (TME) hepatocellular carcinoma (HCC). <h3>Methods</h3> Transcriptome analyses were performed compare proteins responders non-responders among patients receiving Nivolumab. Cytometry...