A5004161651- Dermatology and Skin Diseases
- Gut microbiota and health
- Psoriasis: Treatment and Pathogenesis
- Immune Cell Function and Interaction
- IL-33, ST2, and ILC Pathways
- Vitamin C and Antioxidants Research
- Infant Nutrition and Health
- Cancer Immunotherapy and Biomarkers
- Probiotics and Fermented Foods
- Endoplasmic Reticulum Stress and Disease
Sichuan University
2021-2023
State Key Laboratory of Biotherapy
2021-2023
Abstract The intestinal microbiota has been associated with host immunity as well psoriasis; however, the mechanism of regulating psoriasis needs to be demonstrated systematically. Here, we sought examine its role and action in pathogenesis psoriasis. We found that severity psoriasis-like skin phenotype was accompanied by changes composition microbiota. performed co-housing fecal microbial transplantation (FMT) experiments using K14-VEGF transgenic mouse model transfer from mice severe...
Abstract Interleukin-37b (hereafter called IL-37) was identified as fundamental inhibitor of natural and acquired immunity. The molecular mechanism function IL-37 in colorectal cancer (CRC) has been elusive. Here, we found that transgenic (IL-37tg) mice were highly susceptible to colitis-associated (CAC) suffered from dramatically increased tumor burdens colon. Nevertheless, is dispensable for intestinal mutagenesis, CRC cell proliferation, apoptosis, migration. Notably, dampened protective...
Abstract Background The intestinal microbiota has been associated with host immunity, however, a link psoriasis not demonstrated. Here, we sought to examine its role and mechanism of action in the pathogenesis psoriasis. Results We performed co-housing fecal microbial transplantation (FMT) experiments using K14-VEGF transgenic mouse model Psoriasis severity was accompanied changes composition microbiota. Furthermore, FMT from mice severe exacerbated mild symptoms, increased abundance...