A5002473391- MicroRNA in disease regulation
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Nanoparticle-Based Drug Delivery
- Cancer-related gene regulation
- Cancer, Lipids, and Metabolism
- Protein Degradation and Inhibitors
- Microbial metabolism and enzyme function
- Genetics, Aging, and Longevity in Model Organisms
- Cancer Genomics and Diagnostics
- Bladder and Urothelial Cancer Treatments
- Circular RNAs in diseases
- Renal cell carcinoma treatment
- Nanoplatforms for cancer theranostics
- Retinal Diseases and Treatments
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- PI3K/AKT/mTOR signaling in cancer
- Telomeres, Telomerase, and Senescence
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cancer Mechanisms and Therapy
Wenzhou Medical University
2019-2024
Lishui City People's Hospital
2013-2024
Quzhou University
2024
Shanghai Ninth People's Hospital
2022-2023
Shanghai Jiao Tong University
2016-2023
Shanghai First People's Hospital
2019-2023
National Clinical Research
2023
Shanghai Stomatological Hospital
2023
Ministry of Education of the People's Republic of China
2023
Affiliated Eye Hospital of Wenzhou Medical College
2022-2023
Although immunotherapy has revolutionized oncotherapy, only ≈15% of head and neck squamous cell carcinoma (HNSCC) patients benefit from the current therapies. An immunosuppressive tumor microenvironment (TME) dysregulation polycomb ring finger oncogene BMI1 are potential reasons for failure. Herein, to promote immunotherapeutic efficacy against HNSCC, an injectable nanocomposite hydrogel is developed with a polymer framework (PLGA-PEG-PLGA) that loaded both imiquimod encapsulated CaCO3...
Precancerous lesions of the oral mucosa, especially those accompanied by moderate to severe dysplasia, contribute initiation squamous cell carcinoma (OSCC). However, cellular compositions and spatial organization precancerous stage how these factors promote human OSCC remain unclear. Here, we built a single-cell transcriptome atlas map after obtaining data from pairwise mucosal biopsies 9 individuals consisting very early-stage OSCC, adjacent with as well matched normal region. An altered...
Head and neck squamous cell carcinoma (HNSCC) is a common frequently lethal cancer with few therapeutic options. In particular, there are effective targeted therapies. Development of highly strategies tailored to patients HNSCC remains pressing challenge. To address this, we present pharmacogenomic study facilitate precision treatments for HNSCC. We established large collection 56 patient-derived cells (PDCs), which recapitulated the molecular features original tumors. Pharmacological...
This study identified the function of neural precursor cell expressed developmentally down-regulated 4-like (NEDD4L) on bladder cancer (BLCA).NEDD4L expression in BLCA patients was scrutinized. The NEDD4L viability, apoptosis, migration and invasion cells evaluated by counting kit-8, flow cytometry Transwell assays. effect cisplatin (DDP) resistance DDP-resistant explored. influence p62/Keap1/Nrf2 pathway activity tested Western blot. Rescue experiments were implemented to verify whether...
Abstract Chronic obstructive pulmonary disease (COPD) is a leading aging related cause of global mortality. Small airway narrowing recognized as an early and significant factor for COPD development. Senescent fibroblasts were observed to accumulate in lung patients promote progression through aberrant extracellular matrix (ECM) deposition senescence-associated secretory phenotype (SASP). On the basis our previous study, we further investigated causes increased levels miR-377-3p blood...
Abstract Cancer cell membrane (CCM) derived nanotechnology functionalizes nanoparticles (NPs) to recognize homologous cells, exhibiting translational potential in accurate tumor therapy. However, these nanoplatforms are majorly generated from fixed lines and typically evaluated line-derived subcutaneous-xenografts (CDX), ignoring the heterogeneity differentiation inter- intra- individuals microenvironments between heterotopic- orthotopic-tumors, limiting therapeutic efficiency of such...
Abstract Cetuximab is a widely used drug for treating head and neck squamous cell carcinomas (HNSCCs); however, it provides restricted clinical benefits, its response duration limited by resistance. Here, we conducted randomized “Phase II-like trials” of 49 HNSCC PDX models reveal multiple informative biomarkers intrinsic resistance to cetuximab (e.g., amplification ANKH , up-regulation PARP3). After validating these in another cohort (61 models), generated acquired analyzed them uncover...
Regulator of cullins 1 (ROC1) is an important catalytic subunit cullin-RING E3 ligase. Nuclear factor-kappa B (NF-κB) signaling closely related to tumor invasion and metastasis. Earlier, we reported that ROC1 was associated with a poor prognosis in patients bladder cancer (BCa). However, it unclear whether involved the NF-κB malignant BCa progression.The expression p65 paracancerous tissues were detected by immunohistochemistry (IHC). Pearson correlation used assess between protein...
Hepatocellular carcinoma (HCC) stands as the third leading cause of cancer-related fatalities globally. In this study, we observed a significant increase in expression level YEATS2 gene HCC patients, and it is negatively correlated with patients' survival rate. While have previously identified association between pancreatic cancer cells, regulatory mechanisms significance are still to be fully elucidated. Our study shows that knockdown (KD) leads DNA damage, which turn results an...
Background/aims This study investigated the risk factors for epiretinal membrane (ERM) in eyes with primary rhegmatogenous retinal detachment (RRD) that received silicone oil (SO) tamponade. Methods retrospective analysis included 1140 patients (1140 eyes) RRD who underwent vitrectomy and SO The prevalence of ERM was estimated possible (eg, type 2 diabetes, proliferative vitreoretinopathy (PVR), tamponade time (SOTT), photocoagulation, vitreous haemorrhage, choroidal detachment, cryotherapy...
Abstract Alzheimer′s disease (AD) is a chronic neurodegenerative disorder which the primary cause of dementia in elderly. Telomere attrition has been proposed as hallmark aging. Our study aimed to explore mechanism protection telomere 1 (POT1) regulating length and affecting cellular senescence AD. The AD mouse model was established by d ‐galactose aluminum chloride, water maze test dark avoidance were used detect behaviors mice confirm success model. cell with HT22 cells induced Aβ 42...
Nuclear receptor binding protein 1 (NRBP1) is an evolutionarily highly conserved adaptor with multiple domains. Recently, its role in cancers has received increasing attention. To investigate whether NRBP1 involved the development of bladder cancer, we used tissue microarray and analyzed association between expression levels clinico-pathological features 56 patients diagnosed cancer. Subsequently, was silenced using siRNA cancer cell lines T24 5637, phenotype such as proliferation apoptosis...
Objective: The objective of this study was to investigate the expression serum telomere repeat binding factor 1 (TRF1) and TRF2 in patients with Alzheimer's disease (AD) their correlation clinicopathological features.Methods: Fifty AD subjects 50 healthy controls were enrolled study. Enzyme-linked immunosorbent assay (ELISA) used determine TRF1 peripheral blood plasma. Correlation analysis evaluate between protein clinical parameters.Results: significantly higher than that control group (t =...
Research has shown that the progression of clear cell renal carcinoma (ccRCC) is modulated by long non-coding RNAs (lncRNAs). However, roles specific lncRNAs in malignancy ccRCC are still unknown.TCGA and GSE66272 datasets were used to predict differentially expressed genes (DEGs) ccRCC. ENCORI database was employed display BIRC5 miRNA network potential lncRNA interactions for miRNAs. KM plotter correlation analyses performed identify overall survival (OS)- BIRC5-related Quantitative...
This study aimed to investigate the effects of scaffold matrix attachment region binding protein 1 (SMAR1) on development bladder cancer (BCa). SMAR1 expression in paired tumor and corresponding adjacent normal tissues from 55 BCa patients was detected by quantitative reverse transcription-polymerase chain reaction. cells were transfected regulate expression. treated with XAV-939, LiCl 2-deoxyglucose. The effect viability, proliferation, migration, invasion Warburg researched counting kit-8,...
Purpose To explore the pathological mechanism of Toll-like receptor 4 (TLR4) mediating neovascular age-related macular degeneration (nAMD) and potential role TLR4 coreceptor myeloid differentiation protein 2 (MD2).Methods In study, we inhibited MD2 with chalcone derivative L2H17 utilized a laser-induced choroidal neovascularization (CNV) mouse model Tert-butyl hydroperoxide (TBHP)-challenged rhesus choroid-retinal endothelial (RF/6A) cells to assess effect blockade on CNV.Results Inhibiting...
TAF1B (TATA Box Binding Protein (TBP)-Associated Factor) is an RNA polymerase regulating rDNA activity, stress response, and cell cycle. However, the function of in progression hepatocellular carcinoma (HCC) unknown.In this study, we intended to characterize crucial role molecular mechanisms modulating nucleolar HCC.We analyzed differential expression prognostic value based on The Cancer Genome Atlas (TCGA) database, tumor paraneoplastic tissue samples from clinical patients, typical...
Renal cell carcinoma (RCC) is the largest category of kidney tumors and usually does not have a good prognosis. N6-methyladenosine(m6A) immune infiltration received increased attention because their great influence on clinical outcome prognosis cancer patients.We identified hub genes through multi-dimensional screening, including DEGs, PPI analysis, LASSO regression, random forest. Meanwhile, GO/KEGG enrichment, cMAP prognostic m6A prediction, analysis were performed to understand potential...