A5100395296- Pelvic floor disorders treatments
- Pregnancy and preeclampsia studies
- Cancer Immunotherapy and Biomarkers
- Pelvic and Acetabular Injuries
- Orthopaedic implants and arthroplasty
- Anorectal Disease Treatments and Outcomes
- Reproductive System and Pregnancy
- Epigenetics and DNA Methylation
- Endometrial and Cervical Cancer Treatments
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- RNA modifications and cancer
- Tendon Structure and Treatment
- Autism Spectrum Disorder Research
- Urological Disorders and Treatments
- Resilience and Mental Health
- Wound Healing and Treatments
- Cervical Cancer and HPV Research
- Medical Research and Treatments
- Thyroid Cancer Diagnosis and Treatment
- Liver Disease Diagnosis and Treatment
- Salivary Gland Tumors Diagnosis and Treatment
- Uterine Myomas and Treatments
- Endometriosis Research and Treatment
- Immunotherapy and Immune Responses
Southern Medical University Shenzhen Hospital
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2025
Chengdu Third People's Hospital
2013-2025
Chongqing Medical University
2013-2025
Southwest Jiaotong University
2025
Qinghai No.3 People's Hospital
2024
Chinese PLA General Hospital
2024
China Medical University
2024
Sheng Jing Hospital
2024
International Peace Maternity & Child Health Hospital
2021-2024
Patient-reported outcome questionnaires such as the Foot and Ankle Outcome Score (FAOS) are useful in evaluating results after orthopedic interventions. However, despite being frequently used literature, its validity has not been established for forefoot disorders. Our study aimed to validate FAOS use assessing outcomes of hallux valgus surgery.From 2006 2009, 195 patients with nonarthritic were included construct portion study. Patients had a SF-36 completed. Forty additional patients, both...
Precancerous lesions of the oral mucosa, especially those accompanied by moderate to severe dysplasia, contribute initiation squamous cell carcinoma (OSCC). However, cellular compositions and spatial organization precancerous stage how these factors promote human OSCC remain unclear. Here, we built a single-cell transcriptome atlas map after obtaining data from pairwise mucosal biopsies 9 individuals consisting very early-stage OSCC, adjacent with as well matched normal region. An altered...
The American Orthopaedic Foot and Ankle Society (AOFAS) Ankle-Hindfoot Score has been under recent scrutiny. Outcome (FAOS) is an alternative subjective survey, assessing outcomes in 5 subscales. It validated for lateral ankle instability hallux valgus patients. aim of our study was to validate the FAOS flexible adult acquired flatfoot deformity (AAFD).Patients from authors' institution diagnosed with AAFD 2006 2011 were eligible study. In all, 126 patients who completed Short-Form 12...
Abstract Background The Parkinson's Progression Marker Initiative is an international multicenter study whose main goal investigating markers for disease (PD) progression as part of a path to treatment the disease. This manuscript describes baseline genetic architecture this study, providing not only catalog disease‐linked variants and mutations, but also quantitative measures with which adjust population structure. Methods Three hundred eighty‐three newly diagnosed typical PD cases, 65...
Article14 April 2021Open Access Source DataTransparent process Neurodegenerative VPS41 variants inhibit HOPS function and mTORC1-dependent TFEB/TFE3 regulation Reini E N van der Welle orcid.org/0000-0002-5591-2846 Section Cell Biology, Center for Molecular Medicine, Institute of Biomembranes, University Medical Utrecht, Utrecht University, The Netherlands Search more papers by this author Rebekah Jobling Department Pediatrics, Division Clinical Metabolic Genetics, Hospital Sick Children,...
Abstract Purpose: UDP-glucuronosyltransferases (UGT) are a family of enzymes that glucuronidate many endogenous chemicals, including androgens. This makes them more hydrophilic, alters biological activity, and facilitates their excretion. A deletion polymorphism in the UGT2B17 gene was recently described associated with reduced rate glucuronidation vivo. The purpose this study to determine if is susceptibility prostate cancer. Materials Methods: expression determined by reverse...
The medial collateral ligament is one of the most commonly injured ligaments knee. Most injuries result from a valgus force on increased participation in football, ice hockey, and skiing has all contributed to frequency MCL injuries. Prophylactic knee bracing contact sports may prevent injury; however, performance suffer. majority patients who sustain an injury will achieve their pre-injury activity level with non-operative treatment alone; those combined ligamentous require acute operative...
The aim of this investigation was to analyze a nationally representative admissions database evaluate the effect diabetes mellitus on rate perioperative complications and hospitalization outcomes after ankle arthrodesis (AAD) total arthroplasty (TAA).Using Nationwide Inpatient Sample database, 12 122 patients who underwent AAD 2973 TAA were identified from 2002 2011 based ICD-9 procedure codes. compared between diabetic nondiabetic for each surgery during index hospital stay.The overall...
Objective:To explore the causes and preventive measures of respiratory arrest following general anesthesia in children with obstructive sleep apnea （OSA）, order to enhance safety OSA surgeries under anesthesia. Methods:A retrospective analysis was conducted on clinical follow-up data four pediatric cases that experienced after for at Shenzhen Hospital Southern Medical University from March 2020 2022. Results:All exhibited varying degrees decreased blood oxygen saturation, cyanosis, loss...
ABSTRACT Objective Malignant mesothelioma (MM) is a rare malignant tumor. To explore the clinicopathological characteristics and efficacy of Chinese population with MM in real‐world. Methods Two hundred forty‐eight patients diagnosed between September 2007 August 2024 from three large medical centers (Beijing Hospital, Peking University Cancer Academy Medical Sciences Hospital) were retrospectively analyzed. Kaplan–Meier Cox regression performed. Breast cancer gene 1‐associated protein 1 (...
<title>Abstract</title> Background The physical and mental health of nurses is closely related to the quality nursing patient safety. Nurses face greater risks, which are procrastination. At present, China lacks scientifically effective tools assess level health-related procrastination among clinical nurses. purpose this study was conduct cross-cultural debugging Nurses’ Health-Related Procrastination Scale (NHRPS) test reliability validity Chinese version NHRPS Methods translated strictly...
An amino acid changing polymorphism in the UDP-glucuronosyltransferase (UGT) 2B15 gene has been described at codon 85 (aspartate>tyrosine). The UGT2B15 allele exhibits 2-fold decreased activity for dihydrotestosterone, which was suggested to be associated with risk of prostate cancer based on vitro functional analysis. We determined whether this can used predict individual susceptibility cancer.UGT2B15 expression by reverse transcription-polymerase chain reaction normal tissues. Prevalence...
Abstract Adenomyosis is associated with dysmenorrhea, infertility, and lesional fibrosis. The pathogenesis of adenomyosis still unclear. Plasminogen activator inhibitor 1 (PAI-1) plays important roles in pathological activities like tumor metastasis endometriosis. Our objective was to investigate the expression localization PAI-1 eutopic ectopic endometrium without adenomyosis. We also sought determine relationship between immunoreactivity severity dysmenorrhea extent fibrosis significantly...
We investigated the mechanisms by which respiratory syncytial virus (RSV) infection decreases vectorial Na+ transport across epithelial cells. Mouse tracheal (MTE) cells from either BALB/c or C57BL/6 mice and human airway H441 were grown on semipermeable supports under an air-liquid interface. Cells infected with RSV-A2 mounted in Ussing chambers for measurements of short-circuit currents (I(sc)). Infection RSV 24 hours (multiplicity = 1) resulted positive immunofluorescence antigen less...
The nonstructural protein 1 (NSP1) of rotavirus has been reported to block interferon (IFN) signaling by mediating proteasome-dependent degradation IFN-regulatory factors (IRFs) and (or) the β-transducin repeat containing (β-TrCP). However, in addition these targets, NSP1 may subvert innate immune responses via other mechanisms.The OSU strain as well IRF3 binding domain truncated SA11 are unable degrade IRFs, but can still inhibit host IFN response, indicating that target alternative...
A novel, compact-sized (19 cm × 16 cm) and portable (500 g) magnetic resonance relaxometry system is designed developed. We overcame several key engineering barriers so that technology can be potentially used for disease diagnosis-monitoring in point-of-care settings, directly on biological cells tissues. The whole consists of a coin-sized permanent magnet (0.76 T), miniaturized radio-frequency microcoil probe, compact lumped-circuit duplexer, single board 1-W power amplifier, which field...
Large dense core vesicles (LDCVs) mediate the regulated release of neuropeptides and peptide hormones. They form at trans-Golgi network (TGN), where their soluble content aggregates to a core, but mechanisms controlling biogenesis are still not completely understood. Recent studies have implicated peripheral membrane protein HID-1 in neuropeptide sorting insulin secretion. Using CRISPR/Cas9, we generated KO rat neuroendocrine cells, show that absence results specific defects hormone...
Clostridioides (Clostridium) difficile infection, the leading cause of healthcare-associated diarrhea, represents a significant burden on global healthcare systems. Despite being issue, information C. from perspective is lacking. The aim this study to model phylogeography clinical difficile. Using samples collected MODIFY I and II studies (NCT01241552, NCT01513239), we performed whole-genome sequencing 1501 isolates including 37 novel sequence types (STs), representing largest worldwide...