A5100329429- Cancer Immunotherapy and Biomarkers
- Viral-associated cancers and disorders
- Colorectal Cancer Treatments and Studies
- Lymphoma Diagnosis and Treatment
- Lung Cancer Diagnosis and Treatment
- Hepatitis C virus research
- Lung Cancer Treatments and Mutations
- Lung Cancer Research Studies
- Colorectal Cancer Surgical Treatments
- Cytomegalovirus and herpesvirus research
- Colorectal and Anal Carcinomas
- Pleural and Pulmonary Diseases
- Sinusitis and nasal conditions
- Gastric Cancer Management and Outcomes
- Animal Virus Infections Studies
- Genetic factors in colorectal cancer
- Pancreatic and Hepatic Oncology Research
- Venous Thromboembolism Diagnosis and Management
- Head and Neck Surgical Oncology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Allergic Rhinitis and Sensitization
- Esophageal Cancer Research and Treatment
- Parvovirus B19 Infection Studies
- Oral health in cancer treatment
Roswell Park Comprehensive Cancer Center
2016-2024
Lishui Central Hospital
2023-2024
Tianjin Medical University
2024
Capital Medical University
2008-2023
Chinese Center For Disease Control and Prevention
2023
University of Minnesota
2023
Shanghai Ninth People's Hospital
2023
Shanghai Jiao Tong University
2011-2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2023
First Hospital of China Medical University
2022
Molecular “go” signals reveal their secrets Chemokines are proteins that direct how cells move within the body. For instance, chemokines help immune locate invading pathogens and ensure position themselves correctly a developing organ. Cells detect through G protein–coupled receptors on surface; however, molecular details of these interact remain unclear (see Perspective by Standfuss). Qin et al. solved crystal structure chemokine receptor CXCR4 bound to viral vMIP-II. Burg domain CX3CL1....
Treatment options for recurrent ovarian cancer are of limited clinical benefit and adversely affect patient quality life, representing an unmet need tolerable effective therapies.To assess the efficacy safety a combination pembrolizumab with bevacizumab oral metronomic cyclophosphamide in patients platinum-sensitive, platinum-resistant, or refractory epithelial ovarian, fallopian tube, primary peritoneal cancer.This open-label, single-arm phase 2 cohort study enrolled from September 6, 2016,...
Long-term outcomes of different endoscopic sinus surgery in recurrent chronic rhinosinusitis with
Precancerous lesions of the oral mucosa, especially those accompanied by moderate to severe dysplasia, contribute initiation squamous cell carcinoma (OSCC). However, cellular compositions and spatial organization precancerous stage how these factors promote human OSCC remain unclear. Here, we built a single-cell transcriptome atlas map after obtaining data from pairwise mucosal biopsies 9 individuals consisting very early-stage OSCC, adjacent with as well matched normal region. An altered...
Mucosal melanoma (MM), an aggressive rare subtype of melanoma, is distinct from cutaneous and has poor prognoses. We addressed the lack cell models for MM by establishing 30 organoids human oral (OMM), which retained major histopathological functional features parental tumors. Organoid groups derived chronologically or intratumorally lesions within same individual displayed heterogeneous genetics, expression profiles, drug responses, indicating rapid tumor evolution clinical response....
Noninvasive and convenient biomarkers for early diagnosis of tuberculosis (TB) remain an urgent need. The aim this study was to discover identify potential specific TB. surface-enhanced laser desorption ionization time flight mass spectrometry (SELDI-TOF MS) combined with weak cation exchange (WCX) magnetic beads used screen serum samples from 180 cases TB 211 control subjects. A classification model established by Biomarker Pattern Software (BPS). Candidate protein were purified reverse...
Activation of the Janus kinase (JAK)/signal transducer and activator transcription (STAT) signaling pathway has been associated with numerous human malignancies, including primary effusion lymphomas (PELs). PEL, a cancerous proliferation B cells, is caused by Kaposi's sarcoma-associated herpesvirus (KSHV). Previously we identified constitutive phosphorylation STAT6 on tyrosine 641 (p-STAT6(C)) in PEL cell lines BC3 BCBL1; however, molecular mechanism leading to this activation remains...
Aurora kinase B (AURKB), a central regulator of chromosome segregation and cytokinesis, is aberrantly expressed in various cancer cells. However, the relationship AURKB oncogenic viruses progression remains unclear. Here, we reveal that N-cleaved isoforms exist several oncovirus-associated tumor cells patient tissues, including Kaposi's sarcoma-associated herpesvirus (KSHV), Epstein-Barr virus (EBV), human papillomavirus (HPV). Mechanistically, KSHV-infected cells, latent viral antigen LANA...
Tissue eosinophils have been shown to be associated with polyp recurrence in chronic rhinosinusitis nasal polyps (CRSwNP). We addressed whether the mRNA levels of Charcot-Leyden Crystal (CLC) brushing samples, a molecule mainly released from activated eosinophils, could serve as an effective non-invasive biomarker predict recurrence.A total 51 patients CRSwNP completing postoperative follow-up over period 12-18 months were enrolled. Baseline CLC brushings collected prior endoscopic sinus...
CD40 has major roles in B cell development, activation, and germinal center responses. hypoactivity causes immunodeficiency whereas its overexpression autoimmunity lymphomagenesis. To systematically identify autonomous regulators, we use CRISPR/Cas9 genome-scale screens Daudi cells stimulated by multimeric ligand. These highlight known pathway components reveal multiple additional mechanisms regulating CD40. The nuclear ubiquitin ligase FBXO11 supports expression targeting repressors CTBP1...
The mortality rate of melanoma is very high, but it can usually be cured by minor surgery. A Fast and accurate diagnosis greatly benefit doctors patients. In many medical fields, the performance recent deep-learning-based model close to or even exceed level human experts. this paper, help dermatologists improve efficiency analysis, we employ DenseNet complete recognition melanomas in skin lesion images. proposed trained evaluated with ISIC2020 dataset. Besides, Experimental results show that...
IntroductionTo evaluate the performance of Xpert MTB/RIF Ultra (Xpert-Ultra) in testing pleural tissue and fluid collected by medical thoracoscopy among patients with unexplained exudative effusion.MethodsPatients an undiagnosed effusion were prospectively consecutively recruited. Pleural subjected to culture, (Xpert) Xpert-Ultra assays. Histopathological examination was also performed used as major reference.ResultsSixty-one enrolled, including: 27 tuberculosis (TB) pleurisy, 15 malignancy...
This study aimed to evaluate the transporter-mediated renal excretion mechanism for cilostazol and characterize of drug–drug interaction (DDI) between aspirin or probenecid. Concentrations its metabolites OPC-13015 [6-[4-(1-cyclohexyl-1<i>H</i>-tetrazol-5-yl)butoxy]-2(1<i>H</i>)-quinolinone] OPC-13213 [3,4-dihydro-6-[4-[1-(<i>trans</i>-4-hydroxycyclohexyl)-1<i>H</i>-tetrazol-5-yl]butoxy]-2-(1<i>H</i>)-quinolinone] in rat biologic cell samples were measured by liquid chromatography–tandem...
Members of the cystatin family have increasingly been proven to be involved in several tumors, including gastric cancer (GC) and colorectal (CRC). Cystatin S (CST4) was found upregulated at gene expression level GC cells, making it a potential novel biomarker for early diagnosis gastrointestinal cancer.Quantitative real-time polymerase chain reaction Western blotting analysis were used explore CST4 tissues cell lines. We purified recombinant protein generated anti-CST4 monoclonal antibodies...
Latent Epstein-Barr virus (EBV) infection is strongly associated with several malignancies, including B-cell lymphomas and epithelial tumors. EBNA1 a key antigen expressed in all EBV-associated tumors during latency that required for maintenance of the EBV episome DNA regulation viral gene transcription. However, mechanism utilized by to maintain latent at levels posttranslational remains largely unclear. Here, we report contains two SUMO-interacting motifs (SIM2 SIM3), mutation SIM2, but...