A5005998616- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Gastric Cancer Management and Outcomes
- Colorectal Cancer Treatments and Studies
- Metastasis and carcinoma case studies
- Cancer Genomics and Diagnostics
- Cancer, Hypoxia, and Metabolism
- Machine Learning in Healthcare
- Cytomegalovirus and herpesvirus research
- Histone Deacetylase Inhibitors Research
- Viral-associated cancers and disorders
- Circular RNAs in diseases
- Colorectal and Anal Carcinomas
- Ubiquitin and proteasome pathways
- RNA Research and Splicing
- Extracellular vesicles in disease
- ECG Monitoring and Analysis
- Functional Brain Connectivity Studies
Fudan University Shanghai Cancer Center
2022-2024
Shanghai Medical College of Fudan University
2020-2024
Second Affiliated Hospital of Zhejiang University
2024
Nanjing University of Posts and Telecommunications
2022
Dysfunction of the ubiquitin-proteasome system (UPS) is involved in pathogenesis various malignancies including colorectal cancer (CRC). Ubiquitin domain containing 1 (UBTD1), a ubiquitin-like protein, regulates UPS-mediated protein degradation and tumor progression some types. However, biological function mechanism UBTD1 are far from being well elucidated, its role CRC has not been explored yet. In our study, we analyzed patients' clinical information expression data, found that tissue was...
Long noncoding RNAs (lncRNAs) were recently reported to play an essential role in multiple cancer types. Herein, through next-generation sequencing, we screened metastasis-driving molecules by using tissues from early-stage gastric (GC) patients with lymph node metastasis, and identified a lncRNA LINC01094, which was associated the metastasis of GC. According clinical data TCGA, GSE15459, GSE62254 cohorts, high expression LINC01094 unfavorable prognosis. Moreover, 106 GC paired normal...
Abstract Gastric cancer (GC) is the second cause of cancer-related death and metastasis an important death. Considering difficulties in searching for metastatic driver mutations, we tried a novel strategy here. We conducted integrative genomic analysis on GC identified early drivers lead to metastasis. Whole-exome sequencing (WES), transcriptomes targeted-exome (TES) were performed tumors matched normal tissues from 432 Chinese patients, especially comparative between higher...
Latent Epstein-Barr virus (EBV) infection is strongly associated with several malignancies, including B-cell lymphomas and epithelial tumors. EBNA1 a key antigen expressed in all EBV-associated tumors during latency that required for maintenance of the EBV episome DNA regulation viral gene transcription. However, mechanism utilized by to maintain latent at levels posttranslational remains largely unclear. Here, we report contains two SUMO-interacting motifs (SIM2 SIM3), mutation SIM2, but...
It is still controversial whether primary tumor resection (PTR) improves survival in colorectal cancer (CRC) patients with unresectable metastases.Colon were enrolled and randomly allocated to or without PTR after induction chemotherapy XELOX mFOLFOX6, those failure excluded. The endpoint was TTF (time strategy failure) on an intent-to-treat basis. This study registered ClinicalTrials.gov, number NCT02291744.Between April 2015 July 2020, 140 enrolled, 54 excluded due colon obstruction (16),...
Abstract Few biomarkers are available for predicting chemotherapeutic response and prognosis in colorectal cancer (CRC). Long‐noncoding RNAs (lncRNAs) essential CRC development growth. Therefore, studying lncRNAs may reveal potential predictors of chemotherapy CRC. LINC01764 was analyzed using datasets from Fudan University Shanghai Cancer Center's advanced patients’ RNA‐seq The Genome Atlas datasets. Gene set enrichment analysis employed to detect related pathways. Cotransfection...
Currently, there is no recommended standard third-line chemotherapy for metastatic gastric cancer.
Schizophrenia is a severe chronic disabling disease. Prompt treatment of ultra-high-risk individuals in the prodromal phase great significance for preventing development schizophrenia. The purpose this study to find way effectively distinguish with schizophrenia, and analyze important biomarkers There are 101 first-episode drug-naive schizophrenia patients, 49 94 healthy people participated our study. cognition data, cortical thickness local gyrification index these participants were...