A5100403033- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Mental Health Research Topics
- Advanced MRI Techniques and Applications
- Neural dynamics and brain function
- Neural and Behavioral Psychology Studies
- Advanced Neuroimaging Techniques and Applications
- Neuroinflammation and Neurodegeneration Mechanisms
- EEG and Brain-Computer Interfaces
- Hearing Loss and Rehabilitation
- Neuroscience and Music Perception
- Olfactory and Sensory Function Studies
- Advanced Chemical Sensor Technologies
- Machine Learning in Healthcare
- Blood groups and transfusion
- Bariatric Surgery and Outcomes
- Noise Effects and Management
- Pelvic floor disorders treatments
- Diet and metabolism studies
- Fetal and Pediatric Neurological Disorders
- Atomic and Subatomic Physics Research
- Platelet Disorders and Treatments
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Heart Rate Variability and Autonomic Control
- ECG Monitoring and Analysis
Nanjing Brain Hospital
2020-2025
Nanjing Medical University
2020-2025
Shanghai Sixth People's Hospital
2025
Shanghai Jiao Tong University
2025
Jiangsu Province Hospital
2025
Huaian First People’s Hospital
2024
Institute of Microbiology
2020-2021
Nanjing University of Posts and Telecommunications
2020
Beijing Normal University
2018
Purdue University West Lafayette
2017-2018
Abstract SARS-CoV-2 infection causes a wide spectrum of clinical manifestations in humans, and olfactory dysfunction is one the most predictive common symptoms COVID-19 patients. However, underlying mechanism by which leads to disorders remains elusive. Herein, we demonstrate that intranasal inoculation with induces robust viral replication epithelium (OE), not bulb (OB), resulting transient humanized ACE2 (hACE2) mice. The sustentacular cells Bowman’s gland OE were identified as major...
Abstract Background In this study, we investigated the gender differences in influencing factors of violent behavior patients with schizophrenia. Methods About 519 were evaluated using Repeatable Battery for Assessment Neuropsychological Status (RBANS) and Positive Negative Syndrome Scale (PANSS). A regression analysis model was used to investigate gender-related that influence We also cognitive function among schizophrenia exhibiting behavior. Results found male are more likely engage than...
To the Editor: Obesity and type 2 diabetes (T2D) present significant health issues in China. Despite generally having lower body mass index (BMI) thresholds than Western populations, Chinese individuals often experience higher rates of central obesity, leading to increased metabolic risks even at BMI levels. The prevalence T2D among adults China is estimated be 11.2%. Traditional treatments, including lifestyle interventions medications, fail achieve sustained weight loss effective glycemic...
Abstract Background Prior resting state functional Magnetic Resonance Imaging studies (rs-fMRI) via the regional homogeneity (ReHo) method have demonstrated inconsistent and conflicting results because of several confounding factors, such as small sample size, medicinal influence, illness duration. Relationships between ReHo measures cognitive impairments in patients with drug-naive First-Episode Schizophrenia (dn-FES) are rarely reported. This study was conducted to explore correlations...
Objective: Age of onset is one the heterogeneous factors in schizophrenia, and an earlier disease indicated a worse prognosis. The left superior frontal gyrus (SFG) involved numerous cognitive motor control tasks. Hence, we explored relationship between abnormal changes SFG resting-state functional connectivity (rsFC) function peak age incidence to understand better pathophysiological mechanism youth-onset drug-naïve schizophrenia search for reliable biomarkers. Methods: About 66 patients 59...
Background: An early and correct diagnosis is crucial for treatment of unipolar depression (UD) bipolar disorder (BD). The fractional amplitude low-frequency fluctuations (fALFF) has been widely used in the study neuropsychiatric diseases, as it can detect spontaneous brain activities. This was conducted to survey changes fALFF within various frequency bands UD BD patients, well explore effects on fALDD cognitive function. Methods: In total, 58 drug-naïve first-episode including 32 26 BD,...
Objective Resting state functional magnetic resonance imaging (rsfMRI) provides a lot of evidence for local abnormal brain activity in schizophrenia, but the results are not consistent. Our aim is to find out consistent regions patients with schizophrenia by using regional homogeneity (ReHo), and indirectly understand degree damage drug-naive first episode (Dn-FES) chronic schizophrenia.Methods We performed experiment activation likelihood estimation (ALE) software analysis differences...
The purpose of this study was to investigate the effects 2nd language proficiency and linguistic uncertainty on performance listening effort in mixed contexts.Thirteen native speakers Dutch with varying degrees fluency English listened repeated sentences produced both presented presence single-talker competing speech English. Target masker combinations were blocked (unpredictable) conditions. In condition, each block trials target-masker combination remained constant, listeners informed...
Background Schizophrenia, regarded as a neurodevelopmental disorder, is characterized by positive symptoms, negative symptoms and cognitive dysfunction. Investigating the spontaneous brain activity in patients with schizophrenia can help us understand underlying pathophysiologic mechanism of schizophrenia. However, results concerning abnormal neural activities their correlations dysfunction/psychopathology were inconsistent. Methods We recruited 57 first-diagnosed drug-naive 50 matched...
The etiology of schizophrenia is unknown and associated with abnormal spontaneous brain activity. There are no consistent results regarding the change in activity people schizophrenia. In this study, we determined specific changes amplitude low-frequency fluctuation/fractional fluctuation (ALFF/fALFF) regional homogeneity (ReHo) patients drug-naïve first-episode (Dn-FES).A comprehensive search databases such as PubMed, Web Science, Embase was conducted to find articles on resting-state...
The current study aimed to examine the cognitive profiles and cortical structural alterations in first-episode drug-naïve schizophrenia with AVH (auditory verbal hallucination). Cortical parameters including thickness local gyrification index (LGI) estimated using FreeSurfer as well performance assessed on MATRICS Consensus Cognitive Battery (MCCB) were acquired from 78 patients AVH, 74 without (non-AVH), 76 healthy controls (HC). Hoffman Auditory Hallucination Rating Scale (HAHRS) was...
Abstract Olfactory dysfunction caused by SARS-CoV-2 infection represents as one of the most predictive and common symptoms in COVID-19 patients. However, causal link between olfactory disorders remains lacking. Herein we demonstrate intranasal inoculation induces robust viral replication epithelium (OE), resulting transient humanized ACE2 mice. The sustentacular cells Bowman’s gland OE were identified major targets before invasion into sensory neurons. Remarkably, triggers cell death immune...
To use proteomic techniques to identify sensitive diagnostic biomarkers for paediatric immune thrombocytopenia (ITP). We selected children in ITP and control groups, using a four-dimensional data-independent acquisition approach (4D-DIA) analyse its protein expression. The significantly differentially expressed proteins were enzyme-linked immunosorbent assay (ELISA) validation cohort comprising 50 samples (13 healthy controls, 15 secondary controls 22 with ITP). Receiver operating...
Physiological responses linked to listening effort may differ depending on whether the increased is due masking vs. distortion of speech signal (Francis, et al. 2016; Zekveld, 2014), suggesting that listeners engage different cognitive strategies compensate for sources reduced intelligibility. Here, we assessed physiological and behavioral indices in participants short stories two conditions: (1) nonnative-accented quiet (2) native-accented masked by speech-shaped noise. Compared previous...
Abstract Background: Prior resting state functional magnetic resonance imaging studies via the regional homogeneity (ReHo) method have demonstrated inconsistent and conflicting results because of several confounding factors, such as small sample size, medicinal influence, illness duration. Relationships between ReHo measures cognitive impairments in patients with drug-naive first-episode schizophrenia (dn-FES) are rarely reported. This study was conducted to explore correlations measures,...
Abstract Background Prior resting state functional magnetic resonance imaging studies via the regional homogeneity (ReHo) method have demonstrated inconsistent and conflicting results because of several confounding factors, such as small sample size, medicinal influence, illness duration. Relationships between ReHo measures cognitive impairments in patients with drug-naive first-episode schizophrenia (dn-FES) are rarely reported. This study was conducted to explore correlations measures,...
Schizophrenia is a severe chronic disabling disease. Prompt treatment of ultra-high-risk individuals in the prodromal phase great significance for preventing development schizophrenia. The purpose this study to find way effectively distinguish with schizophrenia, and analyze important biomarkers There are 101 first-episode drug-naive schizophrenia patients, 49 94 healthy people participated our study. cognition data, cortical thickness local gyrification index these participants were...