Cunchuan Wang
A5083152986- Bariatric Surgery and Outcomes
- Body Contouring and Surgery
- Thyroid and Parathyroid Surgery
- Diet and metabolism studies
- Gastric Cancer Management and Outcomes
- Liver Disease Diagnosis and Treatment
- Thyroid Cancer Diagnosis and Treatment
- Head and Neck Anomalies
- Cardiovascular Disease and Adiposity
- Obesity and Health Practices
- Esophageal and GI Pathology
- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Nutrition and Health in Aging
- Adipose Tissue and Metabolism
- Voice and Speech Disorders
- Adipokines, Inflammation, and Metabolic Diseases
- Diet, Metabolism, and Disease
- Pancreatic function and diabetes
- Cardiac, Anesthesia and Surgical Outcomes
- Growth Hormone and Insulin-like Growth Factors
- Cancer-related molecular mechanisms research
- COVID-19 and healthcare impacts
- Pancreatitis Pathology and Treatment
- Gastroesophageal reflux and treatments
First Affiliated Hospital of Jinan University
2016-2025
University of Hong Kong
2019-2024
Jinan University
2002-2024
Capital Institute of Pediatrics
2024
American Society for Metabolic and Bariatric Surgery
2023
Jinan University
2023
Shenzhen Bao'an District People's Hospital
2023
Hong Kong Baptist University
2022
Peking University
2021
Boston Children's Hospital
2021
Adipose tissue macrophage (ATM) inflammation is involved with meta-inflammation and pathology of metabolic complications. Here we report that in adipocytes, elevated lactate production, previously regarded as the waste product glycolysis, serves a danger signal to promote ATM polarization an inflammatory state context obesity. Adipocyte-selective deletion dehydrogenase A (Ldha), enzyme converting pyruvate lactate, protects mice from obesity-associated glucose intolerance insulin resistance,...
Abstract Introduction The International Federation for Surgery Obesity and Metabolic Disorders (IFSO) Global Registry aims to provide descriptive data about the caseload penetrance of surgery metabolic disease obesity in member countries. presented this report represent key findings eighth IFSO Registry. Methods All existing Bariatric (MBS) registries known were invited contribute report. Aggregated was provided by each MBS registry team at Australia New Zealand (ANZBSR) securely stored on a...
Abstract Gut microbiota is linked to human metabolic diseases. The previous work showed that leucine deprivation improved dysfunction, but whether alters certain specific species of bacterium brings these benefits remains unclear. Here, this finds gut composition, which sufficient and necessary for the improvements induced by deprivation. Among all affected bacteria, B. coccoides markedly increased in feces leucine‐deprived mice. Moreover, gavage with improves insulin sensitivity reduces...
To compare long term effects of two bariatric procedures for Chinese type 2 diabetes mellitus (T2DM) patients with a body mass index (BMI) 28-35 kg/m(2).Sixty four T2DM Glycated hemoglobin A1c (HbA1c) ≧ 7.0 % were randomly assigned to receive laparoscopic sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) procedure. Weight, percentage excess weight loss (%EWL), BMI, waist circumference, HbA1c, fasting blood glucose (FBG), and C-peptide measured. Serum lipid levels also measured...
Development of liver fibrosis results in drastic changes the microenvironment, which turn accelerates disease progression. Although pathological function various hepatic cells fibrogenesis is identified, crosstalk between them remains obscure. The present study demonstrates that expression adipocyte fatty acid binding protein (A-FABP) induced especially sinusoidal endothelial (LSECs) mice after bile duct ligation (BDL). Genetic ablation and pharmacological inhibition A-FABP attenuate BDL- or...
Copper deficiency has emerged to be associated with various lipid metabolism diseases, including non-alcoholic fatty liver disease (NAFLD). However, the mechanisms that dictate association between copper and metabolic diseases remain obscure. Here, we reveal restoration caused by hepatic ceruloplasmin (Cp) ablation enhances catabolism promoting assembly of copper-load SCO1-LKB1-AMPK complex. Overnutrition-mediated Cp elevation results in loss, whereas restores content normal level without...
Abstract Metabolic and bariatric surgery (MBS) is widely considered the most effective option for treating obesity, a chronic, relapsing, progressive disease. Recently, American Society of Bariatric Surgery (ASMBS) International Federation Obesity Disorders (IFSO) issued new guidelines on indications MBS, which have superseded previous 1991 National Institutes Health guidelines. The aim this study to establish first set consensus selecting procedures in Class I II using an Expert Modified...
Background: Natural orifice translumenal endoscopic surgery (NOTES®; American Society for Gastrointestinal Endoscopy [Oak Brook, IL] and of Endoscopic Surgeons [Los Angeles, CA]) is gaining interest because it allows operations without skin incisions. The aim this study was to evaluate the feasibility, safety, cosmetic results thyroidectomy via oral vestibular approach (ETOVA) compared with areola (ETAA) in patients thyroid diseases. Materials Methods: Eighty-two diseases were randomized...
Background and Purpose Increasing energy expenditure through adipocyte thermogenesis is generally accepted as a promising strategy to mitigate obesity its related diseases. However, few clinically effective safe agents are known promote thermogenesis. In this study, 20 traditional Chinese herbal medicines were screened examine whether they induced Experimental Approach The effects of or components isolated from extracts A. membranaceus, on analysed by assessing expression uncoupling protein...
Transforming growth factor-β1 (TGFβ1) has been identified as a major pathogenic factor underlying the development of diabetic nephropathy (DN). However, current strategy antagonizing TGFβ1 failed to demonstrate favorable outcomes in clinical trials. To identify different therapeutic approach, we designed mass spectrometry-based DNA-protein interaction screen find transcriptional repressors that bind TGFB1 promoter and Yin Yang 1 (YY1) potent repressor TGFB1. YY1 bound directly regions...
Dysfunctional triglyceride-very low-density lipoprotein (TG-VLDL) metabolism is linked to metabolic-associated fatty liver disease (MAFLD); however, the underlying cause remains unclear. The study shows that hepatic E3 ubiquitin ligase murine double minute 2 (MDM2) controls MAFLD by blocking TG-VLDL secretion. A remarkable upregulation of MDM2 observed in livers human and mouse models with different levels severity MAFLD. Hepatocyte-specific deletion protects against high-fat...