A5101405152- Soil and Water Nutrient Dynamics
- Plant nutrient uptake and metabolism
- Viral-associated cancers and disorders
- Plant Micronutrient Interactions and Effects
- Immune Cell Function and Interaction
- Herpesvirus Infections and Treatments
- Syphilis Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
- Legume Nitrogen Fixing Symbiosis
- Nanoparticle-Based Drug Delivery
- Phytase and its Applications
- Nanoplatforms for cancer theranostics
- Genital Health and Disease
- Dermatology and Skin Diseases
- Colorectal and Anal Carcinomas
- Psoriasis: Treatment and Pathogenesis
- Hidradenitis Suppurativa and Treatments
- Urologic and reproductive health conditions
- Reproductive tract infections research
- Angiogenesis and VEGF in Cancer
- Acne and Rosacea Treatments and Effects
- Immunodeficiency and Autoimmune Disorders
- Boron and Carbon Nanomaterials Research
- Sirtuins and Resveratrol in Medicine
- Parvovirus B19 Infection Studies
Renji Hospital
2020-2025
Shanghai Jiao Tong University
2020-2025
South China Agricultural University
2017-2022
Shanghai Medical College of Fudan University
2015-2021
Shanghai Stomatological Hospital
2014-2021
Shanghai Skin Disease Hospital
2010-2020
Tongji University
2016-2020
Fudan University
2016-2018
Anhui Medical University
2013-2016
University of Minnesota
2014
As an essential nutrient element, phosphorus (P) plays important role in plant growth and development. Low P availability is a limiting factor for crop production, especially legume crops (e.g. soybean), which require additional to sustain nitrogen fixation through symbiotic associations with rhizobia. Although PHOSPHATE STARVATION RESPONSE 1 (PHR1) or PHR1-like considered as central regulator of phosphate (Pi) homeostasis several species, it remains undefined soybean. In this study, 35...
As a major fraction of soil organic phosphorus (P), phytate‐P is unavailable to plants unless hydrolysed by phytase. However, it remains fragmentary that natural variation in root‐associated phytase activity and its underlying molecular mechanisms plants. In this study, variations were observed among 39 stylo genotypes. Subsequently, purple acid phosphatase (PAP) with activity, SgPAP23, was found be primary contributor the superior extracellular utilization stylo.
Macrophages serve as a pivotal nexus in the pathogenesis of acne vulgaris, orchestrating both elimination Cutibacterium acnes ( C. ) and lipid metabolic regulation while also possessing capacity to exacerbate inflammation induce cutaneous scarring. Additionally, recent investigations underscore therapeutic potential inherent macrophage modulation challenge current anti-inflammatory strategies for vulgaris. This review distills contemporary advances, specifically examining dual roles...
Chitosan, a natural polysaccharide derivate from chitin, offers promising alternative biomaterial for use in wound dressings. In this work, the safety and efficacy of next-generation KA01 chitosan dressing facilitating healing nonhealing chronic wounds was studied. This open multicenter comparative prospective randomized clinical study conducted at three medical centers China. A total 90 patients (45 test group 45 control group) with unhealed including pressure ulcers, vascular diabetic foot...
Activation of the Janus kinase (JAK)/signal transducer and activator transcription (STAT) signaling pathway has been associated with numerous human malignancies, including primary effusion lymphomas (PELs). PEL, a cancerous proliferation B cells, is caused by Kaposi's sarcoma-associated herpesvirus (KSHV). Previously we identified constitutive phosphorylation STAT6 on tyrosine 641 (p-STAT6(C)) in PEL cell lines BC3 BCBL1; however, molecular mechanism leading to this activation remains...
High plasma lactate is associated with poor prognosis of many malignancies, but its role in virally mediated cancer progression and underlying molecular mechanisms are unclear. Epstein-Barr virus (EBV), the first human oncogenic virus, causes several cancers, including B-cell lymphoma. Here, we report that dehydrogenase A (LDH-A) expression production elevated EBV-immortalized B lymphoblastic cells, lactic acid (LA; acidic lactate) at low concentration triggers EBV-infected adhesion,...
High plasma lactate is emerging as a critical regulator in development and progression of many human malignancies. Small RNAs derived from cleavage mature tRNAs have been implicated cellular stresses, but the detailed mechanisms that respond to lactic acid (LA; acidic lactate) are not well defined. Here, using an Epstein-Barr virus (EBV)-immortalized B lymphoblastic cell line (LCL) model, we report LA induces tRNA at anticodon loop, particularly production three 5′-tRNA halves (5′-HisGUG,...
Phosphorus (P) is an essential macronutrient for plant growth that participates in a series of biological processes. Thus, P deficiency limits crop and yield. Although Stylosanthes guianensis (stylo) important tropical legume displays adaptation to low phosphate (Pi) availability, its adaptive mechanisms remain largely unknown. In this study, differences low-P stress tolerance were investigated using two stylo cultivars ('RY2' 'RY5') grown hydroponics. Results showed cultivar RY2 was better...
Phosphorus (P) is an essential macronutrient for plant growth and development. Among adaptive strategies of plants to P deficiency, increased anthocyanin accumulation widely observed in plants, which tightly regulated by a set genes at transcription levels. However, it remains unclear whether other key regulators might control synthesis through protein modification under P-deficient conditions. In the study, phosphate (Pi) starvation led accumulations soybean (Glycine max) leaves,...
Background: Mycoplasma genitalium (M. genitalium) has been shown to be involved in chronic non-gonococcal urethritis (NGU). However, the prevalence and determinants of this emerging sexually transmissible infection among prostatitis patients remain obscure. Methods: Two hundred thirty-five diagnosed with 152 health controls from transmitted diseases (STD) clinics Shanghai, China, were selected. M. was detected initial voided urine (VB1), midstream (VB2), expressed prostatic secretion (EPS)...
Cutaneous granulomas caused by Candida guilliermondii are difficult to cure. In situ photoimmunotherapy (ISPI) is a novel method composed of local photothermal therapy and immunoadjuvant. this study, ISPI was used the first time clinically for cutaneous granuloma itraconazole-resistant C.guilliermondii. A 10-week cycle (1) 5% imiquimod applied topically every other day (2) irradiation lesions with an 808-nm diode laser at Days 14, 28, 42, 56. Here we report our case. patient treated four...