A5101703282- Cancer Mechanisms and Therapy
- Alzheimer's disease research and treatments
- PI3K/AKT/mTOR signaling in cancer
- Cholinesterase and Neurodegenerative Diseases
- Autophagy in Disease and Therapy
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Neuroinflammation and Neurodegeneration Mechanisms
- Cancer-related gene regulation
- RNA modifications and cancer
- Phytochemical compounds biological activities
- Adipose Tissue and Metabolism
- Exercise and Physiological Responses
- Computational Drug Discovery Methods
- Metal complexes synthesis and properties
- Immune cells in cancer
- Multiple Myeloma Research and Treatments
- Cancer, Hypoxia, and Metabolism
- Synthesis and biological activity
- TGF-β signaling in diseases
- Bone Metabolism and Diseases
- Ferrocene Chemistry and Applications
- Cardiac Ischemia and Reperfusion
- Heat shock proteins research
- Medicinal Plants and Neuroprotection
Shenyang Pharmaceutical University
2018-2025
Shaanxi University of Chinese Medicine
2024
Unilever (China)
2024
Renji Hospital
2024
General Hospital of Shenyang Military Region
2013-2024
First Affiliated Hospital of Jiangxi Medical College
2024
Nanchang University
2018-2024
Sichuan University
2021-2023
West China Hospital of Sichuan University
2023
Command Hospital
2023
Ursolic acid (UA) is a natural product which has been shown to possess wide range of pharmacological activities, in particular those with anticancer activity. In this study, 13 novel ursolic derivatives were designed and synthesized an attempt further improve compound potency. The structures the newly compounds confirmed using mass spectrometry, infrared spectroscopy, (1) H NMR. ability UA inhibit cell growth was assayed against both various tumor lines non-pathogenic line, HELF. Analysis...
The molecular mechanisms underlying the endoplasmic reticulum (ER) export and cell surface transport of nascent G protein-coupled receptors (GPCRs) have just begun to be revealed previous studies shown that hydrophobic motifs in putative amphipathic 8(th) α-helical region within membrane-proximal C termini play an important role. In this study, we demonstrate di-acidic membrane-distal, nonstructural C-terminal portions are required for exit from ER plasma membrane angiotensin II receptors,...
Increased inflammatory responses and enhanced reactive oxygen species contribute to hepatic ischemia/reperfusion (I/R) injury, however the modulatory mechanisms haven't been completely unveiled. Here, we report that genetic deficiency of MAPK-activated protein kinase 2 (MK2) protected against I/R injury decreased neutrophil accumulation in MK2-/- mice. Depletion attenuated wide type In response C5a stimulation, neutrophils generated less superoxide which both NADPH oxidase activation p47phox...
Abstract Breast cancer is one of the most frequent cancers among women worldwide. However, there still no effective therapeutic strategy for advanced breast that has metastasized. Aberrant activation PI3K/AKT/mTOR pathway an essential step growth human cancers. In our previous study, we designed and synthesized DHW-208 (2,4-difluoro-N-(5-(4-((1-(2-hydroxyethyl)-1H-pyrazol-4-yl)amino)quinazolin-6-yl)-2-methoxypyridin-3-yl)benzenesulfonamide) as a novel pan-PI3K inhibitor. This study aimed to...
Dear Editor, BACE1 and GSK3β are the key targets for Aβ production tau phosphorylation, respectively. activated phosphorylation of GSK3β, resulting in increase phosphorylation.1 In addition, protein stimulated toxicity, formed Fyn-Aβ pathway, increased postsynaptic Fyn level NMDA receptor sensitivity, thus making neuronal dendrites more sensitive to toxicity.2 Given cross-talk between a well-designed multitarget-directed ligand (MTDL) capable targeting these two enzymes simultaneously may be...
Multidrug resistance (MDR) is considered as a primary hindrance for paclitaxel failure in non-small cell lung cancer (NSCLC) patients, which P-glycoprotein (P-gp) overexpressed and the PI3K/Akt signaling pathway dysregulated. Previously, we designed synthesized DHW-221, dual PI3K/mTOR inhibitor, exerts remarkable antitumor potency NSCLC cells, but its effects underlying mechanisms resistant cells remain unknown. Here, reported first time that DHW-221 had favorable antiproliferative activity...
Vascular hyporeactivity is an important problem associated with sepsis. Although the mechanism involves inflammatory pathway activation, specific therapeutic approaches have not been defined. Glutamine (Gln) has shown to provide some anti-inflammatory effects and improve outcomes in Here, we tested hypothesis that Gln could reduce Escherichia coli lipopolysaccharide (LPS)-induced vascular evaluated role of heat-shock protein 70 (HSP70) induction this process. Twenty-four male Sprague-Dawley...
Objective: To investigate the effects of bone morphogenetic protein-2 (BMP-2) on proliferation, differentiation and apoptosis normal human gastric mucosal cells cancer cells.Methods: Poorly differentiated BGC823 cells, moderately epithelial GES-1 were independently treated with recombinant BMP-2 or its inhibitor Noggin.MTT assay was performed to detect flow cytometry done measure cell cycle immunohistochemistry carried out determine expression cyclin-dependent kinase 4 (CDK4).Results:...
Background: The chemical chaperone 4-phenylbutyric acid (4-PBA) has been shown to relieve endoplasmic reticulum (ER) stress. Therefore, it improves insulin sensitivity and promotes glucose metabolism in skeletal muscle. Glucose transporter type 4 (GLUT4), as a major protein, plays central role metabolism. Until now, unclear whether 4-PBA affects GLUT4 gene expression thus, contributes Methods: C2C12 myotubes were treated with 4-PBA, tunicamycin or butyrate subjected Western blot RT-PCR....
Epilepsy and Alzheimer's disease are common neuropathies with a complex pathogenesis. Both of them have some correlations in etiology, pathogenesis, pathological changes, clinical manifestations treatment.This study investigated the key genes molecular genetic mechanism epilepsy by bioinformatics analysis.Two gene expression profiles were used to screen differentially expressed GEO2R tool. The Gene Ontology (GO) Kyoto Encyclopedia Genome (KEGG) pathway enrichment analysis was performed using...