A5023076380- Natural product bioactivities and synthesis
- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- Synthesis of Organic Compounds
- Bioactive Compounds and Antitumor Agents
- Nanoparticle-Based Drug Delivery
- Phytochemical compounds biological activities
- ATP Synthase and ATPases Research
- Synthesis and biological activity
- Polyamine Metabolism and Applications
- Biological Activity of Diterpenoids and Biflavonoids
- Adipose Tissue and Metabolism
- Advanced biosensing and bioanalysis techniques
- MicroRNA in disease regulation
- Tissue Engineering and Regenerative Medicine
- Biosensors and Analytical Detection
- Phytochemical and Pharmacological Studies
- Phytochemicals and Antioxidant Activities
- Spine and Intervertebral Disc Pathology
- Chemotherapy-induced organ toxicity mitigation
- Autophagy in Disease and Therapy
- Estrogen and related hormone effects
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genomics, phytochemicals, and oxidative stress
- Genetics, Aging, and Longevity in Model Organisms
Nanchang University
2018-2023
Xingtai People's Hospital
2023
Hebei Medical University
2023
Huanggang Central Hospital
2022
Nanjing University
2018
Fuzhou University
2014-2017
Columbia University
2010-2011
University of Liverpool
2011
Rutgers, The State University of New Jersey
2011
Massachusetts Institute of Technology
2011
Abstract IFN-γ mediates responses to bacterial infection and autoimmune disease, but it is also an important tumor suppressor. It upregulated in the gastric mucosa by chronic Helicobacter infection; however, whether plays a positive or negative role inflammation-associated carcinogenesis unexplored. To study this question, we generated H+/K+-ATPase-IFN-γ transgenic mouse that overexpresses murine stomach mucosa. In contrast expected proinflammatory during infection, found overexpression...
Here we showed that ursolic acid (UA), a pentacyclic triterpene natural product, and its novel prodrug derivative US597 suppressed cancer cells adhesion, invasion migration. This effect was accompanied by inhibition of focal adhesion signaling pathway including alterations in ICAM-1, VCAM-1, E-selectin, P-selectin, integrin α6β1, FAK, Src, paxillin PTEN. While oral administration UA or increases survival rate melanoma lung metastasis C57BL/6 mice, treatment extend the above UA....
Ursolic acid (UA) is a naturally bioactive product that exhibits potential anticancer effects. The relatively safe and effective molecule intrigued us to explore way further improve its anti-cancer activity tumor-targeting specificity. In the present study, series of structural modifications UA was achieved, which resulted in significant increase growth inhibition on various cancer cell lines with minimal effects normal cells. leading US597 (UA-4) caused depolarization mitochondrial membrane...
Ursolic acid (UA) is a natural product which has been shown to possess wide range of pharmacological activities, in particular those with anticancer activity. In this study, 13 novel ursolic derivatives were designed and synthesized an attempt further improve compound potency. The structures the newly compounds confirmed using mass spectrometry, infrared spectroscopy, (1) H NMR. ability UA inhibit cell growth was assayed against both various tumor lines non-pathogenic line, HELF. Analysis...
Metastasis currently remains the predominant cause of breast carcinoma treatment failure. The effective targeting metastasis-related-pathways in cancer holds promise for a new generation therapeutics. In this study, we developed an novel Asp-UA conjugate, which was composed classical "old drug" aspirin and low toxicity natural product ursolic acid metastasis. Our results showed that could attenuate adhesion, migration invasion MCF-7 MDA-MB-231 cells more safe manner vitro. Molecular cellular...
The tissues or organs derived decellularized extracellular matrix carry immunogenicity and the risk of pathogen transmission, resulting in limited therapeutic effects. cell dECM cultured vitro can address these potential risks, but its impact on wound remodeling is still unclear. This study aimed to explore role (dECM) extracted from adipose stem cells (ADSCs) skin regeneration. Methods: ADSCs were human tissue. Then we cultivated adipose-derived ADSC-dECM for freeze-drying. Western blot...
Abstract Hypertension is common in elderly population. We designed to search comprehensively for genes that are chronologically shifted their expressions and define contributions vascular aging hypertension. RNA sequencing was conducted senescence‐shifted transcripts human umbilical vein endothelial cells (HUVECs). Small interfering (siRNA), small‐molecule drugs, CRISPR/Cas9 techniques, imaging were used determine genes' function age‐related phenotypes of the cell blood vessel. Of 25...
Methotrexate (MTX) is widely used to treat cancers and systemic autoimmune diseases. However, it severely toxic healthy cells, especially those of the reproductive system, therefore poses a great risk patient fertility. In addition, underlying mechanism MTX-induced toxicity has not yet been fully elucidated. Here, spermatocyte cell line (GC2) was as an in vitro model system determine whether MTX induces autophagy apoptosis, elucidate role reactive oxygen species (ROS) Ca2+ these two...
Triptolide has been shown to exert various pharmacological effects on systemic autoimmune diseases and cancers. However, its severe toxicity, especially reproductive prevents widespread clinical use for people with fertility needs. Noncoding RNAs including lncRNAs circRNAs are novel regulatory molecules that mediate a wide variety of physiological activities; they crucial spermatogenesis their dysregulation might cause male infertility. whether involved in triptolide-induced toxicity is...
Cancer metastasis caused by circulating tumor cells (CTCs) accounts for 90% cancer-related death worldwide. Blocking the circulation of CTCs in bloodstream and their hetero-adhesion to vascular endothelia distant metastatic organs may prevent cancer metastasis. Nanomaterial-based intervention with adhesion between has not been reported. Driven novel idea that multivalent conjugation EpCAM Slex antibodies dendrimer surface enhance capacity specificity nanomaterial conjugates capturing...
The anticancer properties of ursolic acid (UA) and metformin (Met) have been well demonstrated. However, whether these compounds can act synergistically to prevent treat cancer is not known. We present in this study, the synergism between UA Met, that a new codrug made Met (UA-Met) against several cell lines. combination high concentration (25, 50, 75, 100 μM) (5, 10, 20, 40 mM) resulted synergetic cytotoxicity on MDA-MB-231 MCF-7 cells (CI < 0.8). Molecular cellular studies showed UA-Met...
More than 90% of kidney cancers are attributed to renal cell carcinoma (RCC), which is however highly resistant traditional chemotherapy. The challenges met in treating RCC signify an imperative accelerate the development new and effective drugs. Preclinical testing has served as a foundation for evaluating potential effectiveness drugs, but this endeavor deeply restricted by current generation vitro two-dimensional culture models, cannot accurately mimic tumor microenvironment (TME)....
Seventeen novel emodin derivatives were synthesized, and the structures confirmed by IR, H NMR, MS, elemental analysis. The cytotoxic activity of was evaluated against A375, BGC-823, HepG2, HELF cells MTT assay. Compound 9a with highest potency low toxicity selected to further investigate its detailed molecular mechanism. lead compound induced a loss mitochondrial transmembrane potential (▵Ψm), an increase in reactive oxygen species (ROS), release cytochrome c activation caspase-3 caspase-9....
To study the regulatory effect of miR-200a on mesenchymal-epithelial transition factor (MET) and its impact biological behavior hepatoma carcinoma cells.