A5100667745- Food composition and properties
- Polysaccharides Composition and Applications
- Pharmacological Effects of Natural Compounds
- Microbial Metabolites in Food Biotechnology
- Cytokine Signaling Pathways and Interactions
- Radiopharmaceutical Chemistry and Applications
- Proteins in Food Systems
- Nanoparticle-Based Drug Delivery
- Immunotherapy and Immune Responses
- Cancer Cells and Metastasis
- Chemokine receptors and signaling
- Diet and metabolism studies
- Polysaccharides and Plant Cell Walls
- Crystal structures of chemical compounds
- Metal complexes synthesis and properties
- Tea Polyphenols and Effects
- Estrogen and related hormone effects
- Phytochemicals and Antioxidant Activities
- Nanoplatforms for cancer theranostics
- Natural Antidiabetic Agents Studies
- Gut microbiota and health
- Enzyme Production and Characterization
- Organometallic Compounds Synthesis and Characterization
- Fibroblast Growth Factor Research
- Tannin, Tannase and Anticancer Activities
Center for Innovation
2025
Qilu University of Technology
2025
Shandong Academy of Sciences
2025
Fuzhou University
2015-2024
Fujian Provincial People's Hospital
2024
Fujian Provincial Hospital
2024
China National Research Institute of Food and Fermentation
2023
China Agricultural University
2008-2021
Fujian Agriculture and Forestry University
2008-2019
Institute of Catalysis and Petrochemistry
2017-2018
Hyperuricemia (HUA) is a prevalent metabolic disorder associated with chronic disease, posing significant global health challenges. Coix seed, traditional cereal, has shown therapeutic potential against HUA, oligosaccharides serving as its primary active components. However, the mechanisms of seed in HUA management remain underexplored. In this study, novel oligosaccharide was isolated from (CSO) through enzymatic hydrolysis and column chromatography. Structural analysis revealed that CSO...
Pectin, as a kind of soluble dietary fiber in hawthorns, exhibits wide range biological activities. Nevertheless, its role and mechanism ulcerative colitis (UC) remain unclear. In this study, the effect hawthorn pectin (HP) against dextran sulfate sodium (DSS)-induced UC mice underlying were evaluated. HP dramatically alleviated pathological symptoms related to mice, displaying an increase body weight colon length inhibition damage. Importantly, inhibited serum levels inflammation-related...
Abstract BACKGROUND: Traditional kombucha tea (TKT) is produced by mixed fungus. We previously proposed Gluconacetobacter sp. A4 as the key functional strain in culture, because it had strong ability to produce D ‐saccharic acid‐1,4‐lactone (DSL, a crucial component KT). This study investigated hypocholesterolaemic and antioxidant activities of TKT modified KT (MKT, broth fermented single A4). RESULTS: In vitro , MKT, but not DSL equally increased radical scavenging effects inhibited low...
// Liyuan Wan 1,* , Haiyan Dong Huo Xu 1 Ji Ma Yewei Zhu Yusheng Lu Jichuang Wang Ting Zhang Tao Li Jingjing Xie Bo 2 Fangwei 3 Yu Gao Jingwei Shao Xiaohuang Tu 4 and Lee Jia Cancer Metastasis Alert Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory on Energy Environment, College Chemistry, Fuzhou University, Fuzhou, China Obstetrics Gynecology, General Hospital, Department Medicine Oncology, East Hospital Xiamen Surgery, * These authors have contributed equally to this...
In this study, we investigated the interventional effect of resistant starch (RS) obtained from purple yam (Dioscorea alata L.) on regulating lipid metabolism and gut microbiota in hyperlipidemic hamsters. Compared to low level RS (LR) treatment, high dosage (HR) administration hamsters was shown be more efficient controlling body weight adipose tissue mass, increased high-density lipoprotein cholesterol (HDL-C) concentration decreased triglyceride (TG), total (TC), low-density (LDL-C)...
Recent global epidemiological studies revealed the lower ovarian cancer death from long‐term use of oral contraceptives. However, underlying mechanism action is not clear. Here, we abortifacient metapristone (RU486 derivative) to test hypothesis that contraceptives might interrupt CXCL12/CXCR4 chemokine axis inhibit metastasis. Metapristone at concentrations (<IC50) remarkably reduces CXCL12‐induced CXCR4 expression on SKOV‐3 and IGROV‐1 cell lines, down‐regulates CXCR4‐related mRNAs...
Rare circulating tumor cells (CTCs) cause >50% of primary colorectal cancer survivors to develop deadly metastasis at 3–5 years after surgery; current bi-aptamer-targeted mesoporous silica nanoparticles loaded with doxorubicin were developed for effective low dose chemoprevention.
// Ning Zheng 1, 2 , Jiahang Chen Weiqun Liu Jian Tao Li Hongning Jichuang Wang 3 and Lee Jia 1 Cancer Metastasis Alert Prevention Center, Biopharmaceutical Photocatalysis, State Key Laboratory of Photocatalysis on Energy Environment, Fuzhou University, 350002, China Fujian Provincial Chemoprevention Chemotherapy, for Translational Research in Neurodegenerative Diseases, Institute Medicine, Medical 350108, Correspondence to: Jia, email: pharmlink@gmail.com cmapcjia1234@163.com Keywords:...
The<italic>in vitro</italic>prebiotic effects of resistant starch (RS), prepared by different treatments from purple yam, on<italic>Bifidobacterium adolescentis</italic>were investigated.
AbstractObjective: Mifepristone (RU486) is an oral first-line contraceptive used by hundreds of millions women, and recently it was tested for anticancer activity in both genders worldwide. We are developing metapristone (the N-monodemethyl RU486) as a potential metastasis chemopreventive. The present acute 30-d subacute toxicity study aimed at examining compared parallel the two drugs.Methods: single-dose studies were conducted mice rats, respectively, gavaging or mifepristone various...
// Jingwei Shao 1, * , Guirong Zheng Hongning Chen Jian Liu 1 Aixiao Xu Fan Tao Li Yusheng Lu Jianguo Ning and Lee Jia Cancer Metastasis Alert Prevention Center, Fujian Provincial Key Laboratory of Chemoprevention Chemotherapy, Fuzhou University, 350002, China These authors have contributed equally to this work Correspondence to: Jia, email: pharmlink@gmail.com cmapcjia1234@163.com Keywords: non-small cell lung cancer, EGFR, metapristone, proliferation, apoptosis Received: March 09, 2017...
Metapristone is the primary metabolite of abortifacient mifepristone (RU486), and being developed as a safe effective cancer metastatic chemopreventive agent for both sexes. Here, we systematically investigated sex-related pharmacokinetics metapristone in rats dogs, explored related mechanisms actions. Administration to dogs showed that plasma concentrations (AUC, C max ) were significantly higher female than males. The differences become more significant after ten consecutive days oral...
Cancer metastasis remains the primary cause of cancer-related death worldwide. In a previous study, we found that levels BTB/POZ domain-containing protein KCTD12 are lower in metastatic melanoma cells than parental cells. The purpose this study was to identify roles cancer metastasis.The Genome Atlas (TCGA) datasets were used evaluate relationship between and skin cutaneous (SKCM) prognosis. effects endogenous on biological behaviors examined using MTT assay. impacts stemness explored...
Although overall survival data are still premature, the PROpel study found radiological progression-free (PFS) benefits of abiraterone and olaparib in patients with metastatic castration-resistant prostate cancer (mCRPC). However, for who have not been genetically tested or lack BRCA1/2 mutations (BRCAm), this combination therapy has questioned as a first-line conventional treatment mCRPC, mainly due to significant health economics side effects. In our retrospective study, we that low-dose...
ABSTRACT The freeze‐dried and moisture‐equilibrated mixtures of TCN1 rice starch (RS), hydrocolloids, their exhibited Tgs sub‐Tgs when analyzed by differential scanning calorimetry (DSC). Among mixtures, the compatible mixture, RS high‐methoxyl pectin, only a single Tg between 2 components; whereas incompatible low‐methoxy showed individual components. was partially with guar gum L‐ K‐carrageenan. compatibility further verified dynamic mechanical analyses results similar to DSC. Thus, can be...
The title compound, C(19)H(23)F(2)N(4)O(3) (+)·0.5SO(4) (2-)·2.5H(2)O, an anti-bacterial fluoro-quinolone, crystallized as a racemic twin (major component = 0.633) in the chiral space group P1. asymmetric unit contains two sparfloxacinium cations, one sulfate anion and five mol-ecules of water solvation. bond lengths angles both cations are almost identical. quinoline ring systems essentially planar, mean deviations from best plane being 0.045 (2) 0.054 Å make π-π inter-actions with each...