A5100458274- Pancreatic and Hepatic Oncology Research
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Chemical Reactions and Isotopes
- Gastric Cancer Management and Outcomes
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- SARS-CoV-2 and COVID-19 Research
- Pancreatitis Pathology and Treatment
- Neurological Disease Mechanisms and Treatments
- Cell death mechanisms and regulation
- Toxin Mechanisms and Immunotoxins
- Beetle Biology and Toxicology Studies
- Traditional Chinese Medicine Analysis
- Chromatography in Natural Products
- Renal Diseases and Glomerulopathies
- Fullerene Chemistry and Applications
- Advancements in Transdermal Drug Delivery
- Nephrotoxicity and Medicinal Plants
- Dermatology and Skin Diseases
- COVID-19 Clinical Research Studies
- Vasculitis and related conditions
- Radiopharmaceutical Chemistry and Applications
- Cancer-related Molecular Pathways
- Spine and Intervertebral Disc Pathology
Zhejiang Chinese Medical University
2013-2024
Central Hospital of Wuhan
2024
Mayo Clinic in Arizona
2019-2024
The First People's Hospital of Wenling
2024
WinnMed
2024
Jiangxi University of Traditional Chinese Medicine
2023
Guangxi University of Chinese Medicine
2023
Chengdu Medical College
2023
Nanjing University of Chinese Medicine
2023
Jiangsu Province Hospital
2023
B7‑H3, a newly identified co‑stimulatory molecule, has been reported to be highly expressed in number of types cancer and is associated with poor prognosis. Transwell experiments wound-healing assay were used detect the role over‑expressed B7‑H3 on cell migration invasion colorectal (CRC) cells. The expression level matrix metallopeptidase 9 (MMP‑9) was further investigated by zymography western blot analysis, involvement Janus kinase 2 (Jak2) signal transducer activator transcription 3...
Increasing amounts of nanoplastics (NPs) in the environment are a great threat to human health, causing intestinal inflammation when consumed through seafood and water. There is, however, still lack understanding immunomodulatory role NPs immune cells, especially early signal events behind resulting from ingestion. In this study, we explored dynamic internalization polystyrene their carboxy amino-functionalized products (PS, PS-COOH PS-NH2) followed by activation ROS-MAPK/NF-κB signaling...
Abstract The Zinc-finger E-box-binding Homeobox-1 (ZEB1) is a transcription factor that promotes epithelial–mesenchymal transition (EMT) and acts as an oncogene in KRAS -mutated lung cancer models. Here we report ZEB1 exerts the opposite effect EGFR cells, where it suppresses growth by increasing microRNA-200 targets to antagonize ERBB3, driver of mutant -dependent cell growth. Among these targets, NOTCH1 represses ERBB3 promoter activity expression ERBB3. Furthermore, find inhibitor...
Abstract Current clinical HER2-targeting ADCs, especially T-DXd, have shown strong efficacy in HER2-expressing/mutant cancers, however, with adverse events such as hematologic toxicities and interstitial lung disease (ILD)/pneumonitis. Here we presented a potential best-in-class HER2-directed ADC, SHR-A1811, which was composed of trastuzumab, stable cleavable linker, novel topoisomerase I inhibitor payload (SHR9265). SHR9265 delicately selected exatecan derivative better liposolubility...
Abstract The Spatial Data Lab (SDL) project is a collaborative initiative by the Center for Geographic Analysis at Harvard University, KNIME, Future Lab, China Institute, and George Mason University. Co-sponsored NSF IUCRC Spatiotemporal Innovation Center, SDL aims to advance applied research in spatiotemporal studies across various domains such as business, environment, health, mobility, more. focuses on developing an open-source infrastructure data linkage, analysis, collaboration. Key...
// Liyuan Wan 1,* , Haiyan Dong Huo Xu 1 Ji Ma Yewei Zhu Yusheng Lu Jichuang Wang Ting Zhang Tao Li Jingjing Xie Bo 2 Fangwei 3 Yu Gao Jingwei Shao Xiaohuang Tu 4 and Lee Jia Cancer Metastasis Alert Prevention Center, Pharmaceutical Photocatalysis of State Key Laboratory on Energy Environment, College Chemistry, Fuzhou University, Fuzhou, China Obstetrics Gynecology, General Hospital, Department Medicine Oncology, East Hospital Xiamen Surgery, * These authors have contributed equally to this...
Background: Chemotherapy remains a primary treatment method for advanced pancreatic cancer. However, chemotherapy resistance can influence the therapeutic effect of The mechanism chemotherapeutic agents such as gemcitabine, which is an agent typically used to treat cancer, complicated and be influenced by genes environment. Oridonin tetracyclic diterpenoid compound extracted from traditional Chinese herb Rabdosia labtea. may overcome drug in but researching cancer oridonin not completely...
As a biopharmaceutics classification system (BCS) class IV drug, breviscapine (Bre) has low solubility in water, poor chemical stability, short biological half-life and rapid removal from plasma. This paper prepared Bre nanosuspension (Bre-NS) by an ultrasound-assisted anti-solvent precipitation method. Characterization of Bre-NS was studied using Box-Behnken design concerning drug concentration DMSO, anti-solvent-to-solvent ratio, sonication time. Under the optimized conditions 170 mg/mL...
Henoch-Schonlein purpura (HSP) is the most common type of connective tissue diseases which increasingly occurs in children recent years and its pathogenesis remains unclear. In order to explore immune parameters underlying mechanism with HSP, study involved 1232 patients HSP having different clinical symptoms their laboratory indicators were evaluated. Th1/Th2 imbalance overactivity Th2 cells can cause increase synthesis release immunoglobulins HSP. The number red blood white urine was...
Gastric cancer is one of the most malignant tumor types, and its metastasis a notable cause mortality. Among methods metastasis, lymphatic predominant in gastric cancer. A previous study reported that plasma oxidized low‑density lipoprotein (oxLDL) risk factor associated with development tumors patients abnormal lipid metabolism, but influence oxLDL remains unclear. In present study, concentration from was detected an ELISA kit, vessel density tissues determined by D2‑40 staining. The...
It is generally acknowledged that soil erosion has become one of the greatest global threats to human–environment system. Although Revised Universal Soil Loss Equation (RUSLE) been widely used for estimation, algorithm calculating erodibility factor (K) in this equation remains limited, particularly context China, which features highly diverse types. In order address problem, a modified describing piecewise function gravel content and relative was first time modify factor, because it proven...
Oridonin, an ent-kaurene diterpenoid extracted from the traditional Chinese herb Rabdosia rubescens, has multiple biological and pharmaceutical functions been used clinically for many years. While antitumor function of oridonin corroborated by numerous lines evidence, its anticancer mechanism not well documented. In this study, pancreatic cancer cell line BxPC-3 was as a model to investigate possible through examining effects on viability. The results showed that affected viability in time-...
There is growing interest in the role of physical activity patients with Alzheimer's disease (AD), particularly regarding its impact cognitive function, gut microbiota, metabolites, and neurotrophic factors.
Melanoma is one of the most common malignant tumors. The anti-PD-1 antibody used for treatment metastatic melanoma. Treatment success only 35–40% and a range immune-related adverse reactions can occur. Combination anti-PD1 therapy with other oncology therapies has been attempted. Herein, we assessed whether chlorogenic acid liposomes modified sialic (CA-SAL) combined was efficacious as immunotherapy CA-SAL were prepared characterized. In mouse model B16F10 tumor, mice treated an antibody,...
This study aimed to assess the relevance of laboratory tests in Henoch-Schönlein purpura nephritis (HSPN) classification, and determine accurate classification factors. prospective included 694 HSPN patients who underwent ultrasound-guided percutaneous renal biopsy (PRB). Renal specimens were scored according International Study Kidney Disease Children (ISKDC) classification. Meanwhile, blood samples immediately collected for examination. The associations between parameters assessed....