A5039192432- Extracellular vesicles in disease
- Lymphatic System and Diseases
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Gastric Cancer Management and Outcomes
- Helicobacter pylori-related gastroenterology studies
- Angiogenesis and VEGF in Cancer
- Cancer Genomics and Diagnostics
- Galectins and Cancer Biology
- Cell Adhesion Molecules Research
- Sympathectomy and Hyperhidrosis Treatments
- Ferroptosis and cancer prognosis
- Cancer-related Molecular Pathways
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Viral-associated cancers and disorders
- Cancer, Lipids, and Metabolism
- Cancer-related gene regulation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- T-cell and Retrovirus Studies
- Vascular Malformations Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Vascular Malformations and Hemangiomas
The Seventh Affiliated Hospital of Sun Yat-sen University
2020-2024
Sun Yat-sen University
2017-2024
Southern University of Science and Technology
2023-2024
Jinan University
2024
The First Affiliated Hospital, Sun Yat-sen University
2024
Xi’an Jiaotong-Liverpool University
2024
Third Affiliated Hospital of Guangzhou Medical University
2022
Guangzhou Medical University
2022
Sun Yat-sen University Cancer Center
2020-2022
University of Macau
2022
Significance CRC patients with KRAS mutations are confronted limited targeted therapeutic options. In this study, we have shown that the median survival time for -mutation mCRC diabetes on metformin is 37.8 mo longer than those treated other hypoglycemic drugs in combination standard systemic therapy. Metformin preferentially accumulated cells both primary cell cultures and patient-derived xenografts. The promising activity of has a negative correlation MATE1 expression, which proven to...
Abstract Background Intestinal metaplasia (IM) is classified into complete intestinal (CIM) and incomplete (IIM). Patients diagnosed with IIM face an elevated susceptibility to the development of gastric cancer, underscoring critical need for early screening measures. In addition complexities associated diagnosis, exact mechanisms driving progression cancer in patients remain poorly understood. OLFM4 overexpressed several types tumors, including colorectal, gastric, pancreatic, ovarian...
Distant metastasis is, unfortunately, the leading cause of death in colorectal cancer (CRC). Approximately 50% CRC patients develop liver metastases, while 10-30% pulmonary metastases. The occurrence is considered to be almost exclusively driven by stem cells (CSCs) formation. However, key molecules that confer transformation CRC, and subsequent metastasis, remain unclear. Far upstream element-binding protein 1 (FUBP1), a transcriptional regulator c-Myc, was screened CSCs mass spectrometry...
The absence of non-invasive biomarkers for the early diagnosis colorectal cancer (CRC) has contributed to poor prognosis. Extracellular vesicles (EVs) have emerged as promising candidates monitoring using liquid biopsy. However, complexity EVs isolation procedures and clear targets detecting serum-derived hindered clinical application in CRC diagnosis.
Rapid and precise nucleic acid testing at the point-of-care (POC) is essential for effective screening management of infectious diseases. Current polymerase-based molecular diagnostics often suffer from potential cross-contamination issues, particularly in POC settings. Here, we introduce DECODE, a contamination-free detection platform integrating digital microfluidics (DMF) extraction CRISPR amplification-free assay pathogen detection. The demonstrates sensitivity, detecting target DNA RNA...
Gastric cancer is one of the most malignant tumor types, and its metastasis a notable cause mortality. Among methods metastasis, lymphatic predominant in gastric cancer. A previous study reported that plasma oxidized low‑density lipoprotein (oxLDL) risk factor associated with development tumors patients abnormal lipid metabolism, but influence oxLDL remains unclear. In present study, concentration from was detected an ELISA kit, vessel density tissues determined by D2‑40 staining. The...
Current non-invasive tumor biomarkers failed to accurately identify patients with colorectal cancer (CRC), delaying CRC diagnosis and thus leading poor prognosis. Dysregulation of 5-Methylcytosine (m 5 C) RNA has gradually been reported in various cancers, but their role is rarely mentioned. Our study aimed determine the m C methylation modification blood immune cells for CRC. Peripheral samples were obtained from a total 83 healthy controls 196 patients. We observed that contents markedly...
Abstract Abnormal lipid metabolism is the sign of tumour cells. Previous researches have revealed that lipolytic pathway may contribute to progression colorectal cancer (CRC). However, adipose triglyceride lipase (ATGL) role in CRC cells remains unclear. Here, we find elevated ATGL positively correlates with clinical stages and negatively associates overall survival. Overexpression significantly promotes cell proliferation, while knockdown inhibits proliferation apoptosis vitro. Moreover,...
Effective biomarkers for the diagnosis of colorectal cancer (CRC) are essential improving prognosis. Imbalance in regulation N6-methyladenosine (m 6 A) RNA has been associated with a variety cancers. However, whether m A levels peripheral blood can serve as diagnostic biomarker CRC is still unclear. In this research, we found that immune cells were apparently elevated group compared those normal controls (NCs) group. Furthermore, arose progressed and metastasized, while these decreased after...
Kallistatin has been recognized as an endogenous angiogenic inhibitor. However, its effects on lymphatic endothelial cells and lymphangiogenesis remain poorly understood. Lymphangiogenesis is involved in tumor metastasis via the vasculature various types of tumors. The aim this study was to investigate kallistatin mechanism action involved. Treatment with recombinant protein or overexpression inhibited proliferation, migration tube formation human (hLECs), induced apoptosis hLECs....
Abstract Nasopharyngeal carcinoma (NPC) is one of the most malignant tumors in southern China and Asia, lymph node metastasis an important cause for treatment failure. Lymphangiogenesis a crucial step lymphatic NPC, while little known about lymphangiogenesis NPC. Similar to angiogenesis, lymphangitic neovascularization process balance between pro-lymphangiogenesis anti-lymphangiogenesis factors, but there are few studies on endogenous inhibitors. Pigment epithelium-derived factor (PEDF)...
Infantile hemangioma ( IH ) is a benign tumor that formed by aberrant angiogenesis and undergoes spontaneous regression over time. Propranolol, the first‐line therapy for , inhibits downregulating activation of vascular endothelial growth factor VEGF pathway, which hyperactivated in . However, this treatment reportedly ineffective 10% tumors, 19% patients relapse after propranolol treatment. Both pro‐angiogenic anti‐angiogenic factors regulate angiogenesis, pigment epithelium‐derived PEDF...
Abstract Objectives Due to lack of effective biomarkers for non-small cell lung cancer (NSCLC), many patients are diagnosed at an advanced stage, which leads poor prognosis. Dysregulation N6-methyladenosine (m 6 A) RNA contributes significantly tumorigenesis and tumor progression. However, the diagnostic value m A status in peripheral blood screen NSCLC remains unclear. Methods Peripheral samples from 152 64 normal controls (NCs) were applied assess levels. Bioinformatics qRT-PCR analysis...
Abstract Extranodal NK/T-cell lymphoma (NKTL) is a rare and aggressive form of extranodal with poor prognosis. Currently, there are very limited treatment options for patients advanced-stage disease or those relapsed/recurrent disease. Here we show that Chiauranib, an orally small molecule inhibitor select serine-threonine kinases (aurora B, VEGFRs, PDGFR, CSF1R, c-Kit), inhibited NKTL cell proliferation, induced cycle arrest, as well suppressed the microvessel density in vitro vivo similar...
Background: Non-small cell lung cancer (NSCLC) was a disease with poor outcomes, partly because there were no high-efficiency non-invasive diagnostic biomarkers. The RNA modification status of 5-Methylcytosine (m5C) has been shown to be biomarker for various diseases, but its potentiality NSCLC remained inconclusive. Methods: In this research, we collected peripheral leukocyte samples from 141 patients and 90 normal people as controls evaluate the extent m5C modification. Results: We found...
Colorectal cancer (CRC) is one of the top three most deadly cancers despite using chemotherapy based on oxaliplatin or irinotecan combined with targeted therapy. Chiauranib has recently been identified to be a promising anticancer candidate impressive efficacy and safety. However, role molecular mechanisms in treatment CRC remain elucidated. Our study shows that inhibits cell proliferation induces apoptosis KRAS wild-type cells dose- time-dependent manner, but not mutation ones. Meanwhile,...
Abstract Background Intestinal metaplasia (IM) is classified into complete intestinal (CIM) and incomplete (IIM). Patients diagnosed with IIM face an elevated susceptibility to the development of gastric cancer, underscoring critical need for early screening measures. In addition complexities associated diagnosis, exact mechanisms driving progression cancer in patients remain poorly understood. OLFM4 overexpressed several types tumors, including colorectal, gastric, pancreatic, ovarian...
Extracellular vesicles (EVs) were promising circulating biomarkers for multiple diseases, but whether serum EVs-derived proteins could be used as a reliable tumor biomarker colorectal cancer (CRC) remained inconclusive. In this study, we identified CXCL4 by 4D data-independent acquisition-based quantitative proteomics assay of in 40 individuals and subsequently analyzed levels ELISA 2 cohorts 749 individuals. The results revealed that dramatically elevated CRC patients than benign polyp or...
Background Detection of gastric cancer (GC) at early stages is an effective strategy for decreasing mortality. This study aimed to construct a prediction nomogram based on questionnaire assess the risk developing GC. Methods Our comprised total 4379 participants (2326 from outpatient Fengqing People’s Hospital were considered model development and internal validation, 2053 outpatients endoscopy center Seventh Affiliated Sun Yat-Sen University independent external validation) mucosa status...