A5057105482- Metal-Organic Frameworks: Synthesis and Applications
- Advanced Nanomaterials in Catalysis
- Advanced biosensing and bioanalysis techniques
- Nanoplatforms for cancer theranostics
- Advanced oxidation water treatment
- Covalent Organic Framework Applications
- Environmental remediation with nanomaterials
- Enzyme-mediated dye degradation
- Nanoparticle-Based Drug Delivery
- Adsorption and biosorption for pollutant removal
- Advanced Photocatalysis Techniques
- Ultrasound and Cavitation Phenomena
- Pharmaceutical and Antibiotic Environmental Impacts
- Luminescence and Fluorescent Materials
- Microplastics and Plastic Pollution
- Electrochemical sensors and biosensors
- Molecular Sensors and Ion Detection
- Enzyme Catalysis and Immobilization
- Microbial Metabolism and Applications
- Supramolecular Self-Assembly in Materials
- Synthesis and properties of polymers
- Microbial bioremediation and biosurfactants
- MicroRNA in disease regulation
- Microbial Fuel Cells and Bioremediation
- Water Treatment and Disinfection
UNSW Sydney
2019-2025
First Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2024
Chang Gung University
2023
University of Michigan
2023
Guangdong University of Technology
2015-2020
Sun Yat-sen University
2017
Yangzhou University
2012
Soft structures in nature, such as supercoiled DNA and proteins, can organize into complex hierarchical architectures through multiple noncovalent molecular interactions. Identifying new classes of natural building blocks capable facilitating long-range structuring has remained an elusive goal. We report the bottom-up synthesis a metal-phenolic mesocrystal where self-assembly proceeds on different length scales spatiotemporally controlled manner. Phenolic-based coordination complexes...
Abstract Selecting a suitable support material for enzyme immobilization with excellent biocatalytic activity and stability is critical aspect in the development of functional biosystems. The highly stable metal‐free properties covalent‐organic frameworks (COFs) make them ideal supports immobilization. Herein, we constructed three kinds COFs via biofriendly one‐pot synthetic strategy at room temperature aqueous solution. Among developed (COF‐LZU1, RT‐COF‐1 ACOF‐1), horseradish peroxidase...
Metal-organic frameworks (MOFs) have recently emerged as excellent hosting matrices for enzyme immobilization, offering superior physical and chemical protection biocatalytic reactions. However, multienzyme cofactor-dependent biocatalysis, the subtle orchestration of enzymes cofactors is largely disrupted upon immobilizing in rigid crystalline MOF network, which leads to a much reduced efficiency. Herein, we constructed hierarchically porous MOFs by controlled structural etching enhance...
Despite the promise of metal-organic frameworks (MOFs) as functional matrices for enzyme stabilization, development a stimulus-responsive approach to induce multi-enzyme cascade reaction in MOFs remains critical challenge. Here, novel method using peptide-induced super-assembly is developed programmed reactions on demand. The super-assembled MOF particles containing different enzymes show remarkable 7.3-fold and 4.4-fold catalytic activity enhancements two-enzyme three-enzyme reactions,...
Abstract Biocatalytic metal–organic framework (MOF) composites, synthesized by interfacing MOFs with biocatalytic components, possessing the unprecedented synergetic properties that are hard to achieve via conventional strategies, represent one of next‐generation composite materials for diverse biotechnological applications. Research on applications is still in its preliminary stage, a wide variety studies focusing bioprotection role MOFs. However, their diversity building units,...
Enhancing the enzymatic activity inside metal-organic frameworks (MOFs) is a critical challenge in chemical technology and bio-technology, which, if addressed, will broaden their scope energy, food, environmental, pharmaceutical industries. Here, we report simple yet versatile effective strategy to optimize biocatalytic by using MOFs rapidly "lock" ultrasound (US)-activated but more fragile conformation of metalloenzymes. The results demonstrate that up 5.3-fold 9.3-fold enhancement free...
Abstract Single‐atom catalysts (SACs) exhibit unparalleled atomic utilization and catalytic efficiency, yet it is challenging to modulate SACs with highly dispersed single‐atoms, mesopores, well‐regulated coordination environment simultaneously ultimately maximize their efficiency. Here, a generalized strategy construct active ferric‐centered (Fe‐SACs) developed successfully via biomineralization that enables the homogeneous encapsulation of metalloproteins within metal–organic frameworks...
Abstract Background The dynamic interaction between cancer cells and tumour-associated macrophages (TAMs) in the hypoxic tumour microenvironment (TME) is an active barrier to effector arm of antitumour immune response. Cancer-secreted exosomes are emerging mediators this cancer-stromal cross-talk TME; however, mechanisms underlying remain unclear. Methods Exosomes were isolated with ExoQuick exosome precipitation solution. polarizing effect TAMs was evaluated by flow cytometry, western blot...
Photoluminescent metal–organic frameworks (MOFs) were grown in a living plant (Syngonium podophyllum) via immersing their roots an aqueous solution of disodium terephthalate and terbium chloride hexahydrate sequentially for 12 h without affecting viability. Then, app-assisted MOF–plant nanobiohybrids used the detection various toxic metal ions organic pollutants. Their performance sensing mechanism also evaluated. The results demonstrated that plants served as self-powered preconcentrators...
Abstract Antibody‐nanoparticle conjugates are promising candidates for precision medicine. However, developing a controllable method conjugating antibodies to nanoparticles without compromising the antibody activity represents critical challenge. Here, facile and generalizable film‐coating is presented using zeolitic imidazole framework‐8 (ZIF‐8) immobilize on various in favorable orientation enhanced cell targeting. Different model therapeutic (e.g., Herceptin) assembled via biomineralized...