A5036978179- Reproductive Biology and Fertility
- Assisted Reproductive Technology and Twin Pregnancy
- Epigenetics and DNA Methylation
- Ovarian function and disorders
- Reproductive Health and Technologies
- Reproductive System and Pregnancy
- CRISPR and Genetic Engineering
- Sperm and Testicular Function
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Prenatal Screening and Diagnostics
- Cancer-related gene regulation
- Fetal and Pediatric Neurological Disorders
- Plant Molecular Biology Research
- Kruppel-like factors research
- Ectopic Pregnancy Diagnosis and Management
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Acupuncture Treatment Research Studies
- RNA modifications and cancer
- Pluripotent Stem Cells Research
- Renal Diseases and Glomerulopathies
- RNA and protein synthesis mechanisms
- Hepatitis B Virus Studies
- Adipokines, Inflammation, and Metabolic Diseases
- Maternal and Perinatal Health Interventions
Shanghai University of Traditional Chinese Medicine
2015-2025
Shuguang Hospital
2015-2025
Third Affiliated Hospital of Guangzhou Medical University
2021-2023
Guangzhou Medical University
2021-2023
Guangzhou University of Chinese Medicine
2022
Second Affiliated Hospital of Guangzhou Medical University
2022
Key Laboratory of Guangdong Province
2022
Tongji University
2013
Abstract Oocyte ageing is a key bottleneck and intractable challenge for in vitro fertilization treatment of aged female patients. The underlying molecular mechanisms human oocyte remain to be elucidated. Hence, this study aims investigate the genes relevant biological signalling pathways involved ageing. We isolated mRNA single‐cell RNA sequencing from MII oocytes donated by patients undergoing intracytoplasmic sperm injection. Nine RNA‐seq datasets were analyzed, which included 6 older...
Around 60% of in vitro fertilized (IVF) human embryos irreversibly arrest before compaction between the 3- to 8-cell stage, posing a significant clinical problem. The mechanisms behind this are unclear. Here, we show that arrested enter senescent-like state, marked by cell cycle arrest, down-regulation ribosomes and histones MYC p53 activity. can be divided into 3 types. Type I fail complete maternal-zygotic transition, II/III have low levels glycolysis either high (Type II) or III)...
In this study, we aimed to evaluate the impact of duration cryopreservation storage on embryo viability, implantation competence, pregnancy outcome and neonatal outcomes.We retrospectively evaluated outcomes patients who underwent IVF with vitrified cryopreserved embryos between January 2004 August 2019 by following first frozen transfer cycles within study period. A total 31,143 met inclusion criteria were grouped according time as follows: Group 1 (n = 20,926),1-90 days; 2 6,472), 91-180 3...
Excessive insulin resistance, inadequate compensation, or both could result in gestational diabetes mellitus (GDM). Levels of pigment epithelium-derived factor (PEDF), a novel adipokine that induce are high patients with obesity and diabetes. However, the impact PEDF pregnancy remains unknown.This study aimed to elucidate role on resistance compensatory elevation levels during normal GDM.In this population-based cohort study, logistic regression analysis was performed determine association...
Abstract Objectives Due to lack of effective biomarkers for non-small cell lung cancer (NSCLC), many patients are diagnosed at an advanced stage, which leads poor prognosis. Dysregulation N6-methyladenosine (m 6 A) RNA contributes significantly tumorigenesis and tumor progression. However, the diagnostic value m A status in peripheral blood screen NSCLC remains unclear. Methods Peripheral samples from 152 64 normal controls (NCs) were applied assess levels. Bioinformatics qRT-PCR analysis...
Herein, we aimed to analyse the effects of body mass index (BMI) on treatment outcomes in vitro fertilisation (IVF) a cohort women undergoing their first IVF cycle.A total 2311 cycles from 986 IVF/intracytoplasmic sperm injection cycle with fresh/frozen embryo transfer between January 2018 and December 2021 at Center Reproductive Medicine, Shuguang Hospital affiliated Shanghai University Traditional Chinese were considered this retrospective study. First, included patients classified into...
Many clinical studies have shown that embryos of in vitro fertilization (IVF) are often prone to developmental arrest, which leads recurrent failure IVF treatment. Early embryonic arrest has always been an urgent problem assisted reproduction centers. However, the molecular mechanisms underlying early development remain largely unknown. The objective this study is investigate potential candidate hub genes and key signaling pathways involved stages development. RNA-seq analysis was performed...
Autoantibodies are implicated in various human diseases. In this review, the effects of three different types autoantibodies (antiphospholipid antibody, antithyroid and antisperm antibody) on female reproductive health critically examined. Antiphospholipid antibodies being detected more frequently women undergoing vitro fertilization, but their presence does not appear to influence outcome pregnancy, miscarriage, or live birth rates. Available evidence makes it conclusive that...
Summary The objective of this retrospective study was to determine an optimal time point for vitrification cleavage-stage human embryos. This included patients who were undergoing day 2 or 3 vitrified–warmed embryo transfer at the In Vitro Fertilization (IVF) Programme Shanghai First Maternity and Infant Hospital, China, affiliated Tongji University School Medicine, from April 2010 March 2012. Intervention made entire cohort vitrified embryos poor responder so as avoid severe ovarian...
Human embryos of in vitro fertilization (IVF) are often susceptible to developmental arrest, which greatly reduces the efficiency IVF treatment. In recent years, it has been found that protein arginine methyltransferase 7 (PRMT7) plays an important role process early embryonic development. However, not much is known about relationship between PRMT7 and developmentally arrested embryos. The was thus investigated this study. Discarded human from were collected for experimental materials....
Abstract Around 60% of in vitro fertilized (IVF) human embryos irreversibly arrest before compaction between the 3-8-cell stage, posing a significant clinical problem. The mechanisms behind this are unclear. Here, we show that arrested enter quiescent-like state, marked by cell cycle arrest, downregulation ribosomes and histones MYC p53 activity. Mechanistically, can be divided into three types. Type I fail to complete maternal-zygotic transition, type II/III have erroneously low levels...
Blastocyst selection based on morphology grading is crucial in vitro fertilization (IVF) treatment. Several research studies convolutional neural networks (CNNs) have been reported to select the most viable blastocyst automatically. In this paper, we propose a multimodal representation learning framework which text description firstly streamed as complementary supervision signal enrich visual information. Moreover, redefine assessment problem an image-text retrieval task solve data...
Abstract STUDY QUESTION Is CDC26 a key factor in human oocyte aging? SUMMARY ANSWER The lack of disrupts the oocytes maturation process, leading to aging, but these defects could be partially rescued by overexpression protein. WHAT IS KNOWN ALREADY Age-related aging is main cause female fertility decline. In mammalian oocytes, aberrant meiosis can chromosomal abnormalities that might lead infertility and developmental disorders. participates process. DESIGN, SIZE, DURATION Differential gene...
Hepatitis C virus (HCV) genotype 3 is widely distributed, and 3-infected patients achieve a lower cure rate in direct-acting antiviral (DAA) therapy are associated with higher risk of hepatic steatosis than other genotypes. Thus, the study virology pathogenesis HCV increasingly relevant. Here, we developed full-length infectious clone subgenomic replicon for 3a isolate, CH3a. From an infected serum, constructed CH3a clone, however, it was nonviable Huh7.5.1 cells. Next, systematically...
Abstract Object: This study was to investigate the effect of different human Menotrophin (hMG) initiation doses on in vitro fertilization (IVF) outcomes aged poor ovarian response(POR) patients undergoing ovulation induction with Clomiphene Citrate (CC) combined hMG; Method: The clinical data 142 POR more than 40 years old were collected and divided into 3 groups according dose hMG (Group A=75IU, Group B=150IU, C=225IU). baseline characteristics IVF compared; Results: We found that increase...
To observe the effects of electroacupuncture (EA) on ovarian reaction, egg and embryo quality, as well pregnancy rate in poor response (POR) patients kidney essence deficiency undergoing vitro fertilization-embryo transfer (IVF-ET).Ninety-six who met inclusion criteria were randomly divided into an EA group a control group, with 48 cases each group. Before IVF-ET, received EA, once daily, 2 or 3 treatments week for 12 weeks. after treatment, traditional Chinese medicine (TCM) syndrome score...
Selecting the single best blastocyst based on morphological appearance for implantation is a crucial part of in vitro fertilization (IVF). Various deep learning and computer vision-based methods have recently been applied assessing quality. However, to our knowledge, most previous works utilize classification networks give qualitative evaluation. It would be challenging rank quality with same result. Thus, this paper proposes regression network combined soft attention mechanism...
Abstract Objective: To evaluate the impact of cryopreservation storage duration on embryo viability, implantation competence, pregnancy outcome and neonatal outcomes. Design: Retrospective study. Setting: Center for Reproductive Medicine，The Third Affiliated Hospital Guangzhou Medical University. Patient(s): In vitro fertilization patients who had vitrified cryopreserved embryos following first frozen transfer cycles from January 2004 to August 2019. A total 31143 met inclusion criteria were...