A5101430723- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Metal-Organic Frameworks: Synthesis and Applications
- Magnetism in coordination complexes
- Crystallography and molecular interactions
- Metal complexes synthesis and properties
- Crystal structures of chemical compounds
- Boron Compounds in Chemistry
- MicroRNA in disease regulation
- Cell Adhesion Molecules Research
- Cancer, Lipids, and Metabolism
- Innovative Teaching Methods
- Laser Applications in Dentistry and Medicine
- Epigenetics and DNA Methylation
- Circular RNAs in diseases
- DNA Repair Mechanisms
- Supramolecular Chemistry and Complexes
- COVID-19 and Mental Health
- Hippo pathway signaling and YAP/TAZ
- Healthcare professionals’ stress and burnout
- Cellular Mechanics and Interactions
- Microtubule and mitosis dynamics
- Reproductive System and Pregnancy
- Immune cells in cancer
- Dental Anxiety and Anesthesia Techniques
First Affiliated Hospital of Anhui Medical University
2016-2024
Anhui Medical University
2015-2024
Shuguang Hospital
2019-2024
Shanghai University of Traditional Chinese Medicine
2019-2024
Tongji University
2023
Wuxi People's Hospital
2013-2019
Shanghai Xuhui Central Hospital
2018
Fudan University
2005-2018
Zhongshan Hospital
2018
Shanghai Medical College of Fudan University
2013-2015
Abstract Chemoresistance has been the biggest obstacle in ovarian cancer treatment, and STAT3 may play an important role chemoresistance of multiple cancers, but underlying mechanism long truly illusive, particularly association with p53 RAS signaling. In this study, by using wild type, constitutive active, dominant negative constructs, wild-type p53, RAS-mutant V12, we performed a series vitro vivo experiments gene overexpression, drug animal assays. We found that phosphorylation Y705 not...
Abstract Extracellular matrix protein-1 (ECM1) promotes tumorigenesis in multiple organs but the mechanisms associated to ECM1 isoform subtypes have yet be clarified. We report this study that secretory ECM1a induces through GPR motif binding integrin αXβ2 and activation of AKT/FAK/Rho/cytoskeleton signaling. The ATP cassette subfamily G member 1 (ABCG1) transduces ECM1a-integrin interactive signaling facilitate phosphorylation AKT/FAK/Rho/cytoskeletal molecules confer cancer cell cisplatin...
This study is aimed at identification of miR-195-5p/MMP14 expression in cervical cancer (CC) and their roles on cell proliferation invasion profile CC cells through TNF signaling pathway CC.Microarray analysis, gene set enrichment analysis (GSEA) DAVID were used to analyze differentially expressed miRNAs, mRNAs pathways. MiR-195-5p MMP14 levels determined by qRT-PCR. Western blot was employed measure pathway-relating protein level. Luciferase reporter system confirm the targeting...
Abstract Oocyte ageing is a key bottleneck and intractable challenge for in vitro fertilization treatment of aged female patients. The underlying molecular mechanisms human oocyte remain to be elucidated. Hence, this study aims investigate the genes relevant biological signalling pathways involved ageing. We isolated mRNA single‐cell RNA sequencing from MII oocytes donated by patients undergoing intracytoplasmic sperm injection. Nine RNA‐seq datasets were analyzed, which included 6 older...
The assembly of soluble, air-stable, supramolecular structures {(Zn-TPyP)[Cp*Ir{S2C2(B10H10)}]4(THF)2}(2), {(Cu-TPyP)[Cp*Ir{S2C2(B10H10)}]4(THF)2}(3) and {(Zn-TPyP)[Cp*Ir{S2C2(B10H10)}]2.6(CHCl3)}n (4), based on metal-containing moieties [Cp*Ir{S2C2(B10H10)}] (1) bridged by nitrogen-based organic spacers, are described.
The aims of the present study were to determine whether changes in density and location CD68-positive CD206-positive macrophages contribute progression hepatocellular carcinoma (HCC) evaluate prognostic values these cells post-surgical patients. A retrospective involving 268 HCC patients was conducted. macrophage infiltration tissues adjacent examined by immunohistochemistry (IHC) relationship between clinicopathological features prognosis analyzed. Receiver operating characteristics (ROC)...
REV3L, the catalytic subunit of DNA Polymerase ζ (Polζ), plays a significant role in damage tolerance mechanism translesion synthesis (TLS). The REV3L chemosensitivity cervical cancer needs exploration. In present study, we evaluated expression Polζ protein paraffin-embedded tissues using immunohistochemistry and found that was higher than normal tissues. We then established some cell lines with suppression or overexpression. Depletion suppresses proliferation colony formation cells through...
Tumor-associated macrophages (TAMs) play an important role in tumor development. Increasing research suggests that miR-210 may promote the progression of virulence, but whether its pro-carcinogenic effect primary hepatocellular carcinoma (HCC) is via action on M2 has not been examined. Differentiation THP-1 monocytes into M2-polarized was induced with phorbol myristate acetate (PMA) and IL-4, IL-13. were transfected mimics or inhibitors. Flow cytometry used to identify macrophage-related...
The reactions of half-sandwich rhodium and iridium complexes [Cp'MCl(μ-Cl)]2 with bidentate ligands (L) such as pyrazine, 4,4'-bipyridine (bpy), trans-4,4'-azopyridine gave the corresponding binuclear [{Cp'MCl2}2(L)] (M = Ir, Cp' Cp* η5-C5Me5, L pyrazine (3a), bpy (3b); M Rh, Cpt η5-1,3-tBu2C5H3, (3c), 4,4'-azopyridine (3d)), which can be converted into tetranuclear [{Cp'2M2(μ-Cl)2}2(L)2]4+ Cp*, (4a 4b); Cpt, (4c, 4e), (4d)) on treatment Ag(OTf) or AgBF4 (OTf CF3SO3). Treatment Cl-bridged 4c...
Multicluster molecules [Cp*IrS2C2(B10H10)]n(L) [n = 3 (L tpt), 2 bpy)], connected with pyridyl-based ligands, were prepared and characterized by X-ray crystallography.
Five new silver(I) complexes with dimeric units, namely [Ag2(bib)2](BrO3)21, [Ag2(bib)2](ClO3)22, [Ag2(bib)2](ClO4)23, [Ag2(bib)2](NO3)2·2H2O 4 and [Ag2(bib)2(SCN)2] 5 (bib = 1,3-bis(4,5-dihydro-1H-imidazol-2-yl)benzene), have been synthesized characterized by X-ray diffraction to observe the influence of counter anions on crystal structures. Each bib acts as a bidentate ligand every two ligands ligate pair Ag(I) ions resulting in [2∶2] metallomacrocyclic motif that is further stabilized...
Wentilactone A (WA) is a tetranorditerpenoid isolated from marine algae. We previously found that WA inhibited cancer cell proliferation with little toxicity. In this study, we show high expression of extracellular matrix protein-1 (ECM1) promotes cisplatin resistance, and the secreted ECM1 activates normal fibroblasts (NFs) to transform cells characteristics cancer-associated (CAFs). Transcription gene regulated largely by NF-κB through EP881C/T-EP266C binding sites. supresses...
Five co-ordination polymers 2∞[(AgSCN)2L] (L = 1,2-diaminoethane, 1,3-diaminopropane, 1,4-diaminobutane or 1,5-diaminopentane) and 2∞[(AgSCN)3L] N,N′-bis(3-aminopropyl)ethylenediamine) have been synthesized structurally characterised by single-crystal X-ray diffraction. Each complex contains one-dimensional staircase-like 1∞[(AgSCN)2] chains in which each thiocyanate ligand acts the μ-N,S,S-bridging mode. Every silver(I) atom chain is further co-ordinated a terminal nitrogen of amine to...
Abstract Reaction of the 16‐electron half‐sandwich rhodium and iridium complexes [Cp*M{S 2 C (B 10 H )}] [M = Rh ( 1a ), Ir 1b )] with multidentate ligands (L) such as 5,10,15,20‐tetra(4‐pyridyl)porphyrin) (H TPyP), 2,4,6‐tri(4‐pyridyl)‐1,3,5‐triazine (tpt), 4,4′‐azopyridine, gave corresponding multi‐cluster [Cp*MS n Rh, Ir; 4, L TPyP ); 3, tpt 3 2, 4,4′‐azopyridine 4 N , N′ ‐bis(4‐pyridinylmethylene)biphenyl‐4,4′‐diamine 5 pyrazine, 6 2,5‐di(4‐pyridyl)‐1,3,4‐oxadiazole 7...
Abstract Aim To evaluate the prevalence and influencing factors of anxiety depression symptoms in surgical nurses during COVID‐19 epidemic Anhui, China. Methods A cross‐sectional, multic'entre quantitative study was conducted among Anhui province. SAS, SDS SSRS scales were used for investigation. Data collected between 3 March 2020 to 19 2020. Results total 3,492 completed survey. The average level higher than that Chinese norm. Levels social support significantly negatively associated with...
Two bis-methoxo-bridged dimeric copper(II) complexes, [Cu2(OMe)2(APMD)4](BF4)2 1 and [Cu2(OMe)2(APMD)4](ClO4)2 2, were prepared characterized by x-ray single-crystal structure analysis magnetic susceptibility. Complexes 2 are isomorphous, being composed of discrete [Cu2( w 2-OMe)2(APMD)4]2+ cations anions with each Cu(II) atom ligated two pyrimidine nitrogen atoms (Cu-N , 2.01Å) from APMD ligands oxygen (Cu-O 1.92Å) the -methoxo groups in a distorted square-planar geometry. The...