Mingxiao Chen

ORCID: 0009-0007-6358-767X
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Research Areas
  • Advanced Combustion Engine Technologies
  • Hepatitis C virus research
  • Hepatitis B Virus Studies
  • Catalytic Processes in Materials Science
  • Combustion and flame dynamics
  • SARS-CoV-2 and COVID-19 Research
  • Heat transfer and supercritical fluids
  • Insect and Arachnid Ecology and Behavior
  • HIV/AIDS drug development and treatment
  • Immune Response and Inflammation
  • Respiratory viral infections research
  • Biochemical and Molecular Research
  • Plasma Applications and Diagnostics
  • COVID-19 Clinical Research Studies
  • Neurobiology and Insect Physiology Research
  • Bacillus and Francisella bacterial research
  • Cancer Cells and Metastasis
  • Digital Imaging for Blood Diseases
  • Pomegranate: compositions and health benefits
  • Recycling and Waste Management Techniques
  • Calcium Carbonate Crystallization and Inhibition
  • AI in cancer detection
  • Wind and Air Flow Studies
  • Fire dynamics and safety research
  • NF-κB Signaling Pathways

Anhui Medical University
2024

Nanjing University of Science and Technology
2022-2024

University of Science and Technology of China
2024

Shanxi Medical University
2024

Sun Yat-sen University
2015-2023

Second Affiliated Hospital of Guangzhou Medical University
2022-2023

Guangzhou Medical University
2021-2023

Anhui Provincial Children's Hospital
2023

Shihezi University
2023

Ministry of Agriculture and Rural Affairs
2023

Abstract We describe the cloning of first hymenopteran vitellogenin receptor (VgR) cDNA from imported fire ant, Solenopsis invicta , an invasive pest. Using reverse transcription polymerase chain reaction and rapid amplification ends, fragments encompassing entire coding region a putative VgR were cloned sequenced. The complete 5764 bp encodes 1782 residue protein with predicted molecular mass 201.3 kDa (= Si VgR). Northern blot analysis demonstrated that 7.4 kb transcript was present only...

10.1111/j.0962-1075.2004.00477.x article EN Insect Molecular Biology 2004-03-29

Homologous booster, heterologous and Omicron variants breakthrough infection (OBI) could improve the humoral immunity against variants. Questions concerning about memory B cells (MBCs) T variants, features of long-term immunity, after booster OBI, needs to be explored. Here, comparative analysis demonstrate antibody cell ancestral strain, Delta in infected patients (OBIPs) are comparable that Ad5-nCoV boosted healthy volunteers (HVs), higher than inactivated vaccine (InV) HVs. However, was...

10.1016/j.virs.2022.12.008 article EN cc-by-nc-nd Virologica Sinica 2023-01-02

Conducting the investigation of flame dynamics perturbed by acoustic waves had guiding significance for extinguishing technology. In this paper, behavior inverse diffusion under influence 200–300 Hz sound was reported first time. Detailed analysis entire process from steady state to extinction, including structure, periodic characteristics, temperature and KL factor distribution. The relationship between morphology parameters established through dimensionless analysis. addition, performance...

10.1080/00102202.2024.2366397 article EN Combustion Science and Technology 2024-06-13

Abstract Background The pathogenicity and virulence of the Omicron strain have weakened significantly pathogenesis variants. Accumulating data indicated accessory proteins play crucial roles in host immune evasion virus SARS-CoV-2. Therefore, impact simultaneous deletion protein ORF7a, ORF7b ORF8 on clinical characteristics specific immunity breakthrough infected patients (BIPs) need to be verified. Methods Herein, plasma cytokines were identified using a commercial Multi-cytokine detection...

10.1186/s12985-023-02066-3 article EN cc-by Virology Journal 2023-05-29

Little information is available for antibody levels against SARS-CoV-2 variants of concern induced by Omicron breakthrough infection and a third booster with an inactivated vaccine (InV) or Ad5-nCoV in people completion two InV doses. Plasma was collected from pre-vaccinated Omicron-infected patients (OIPs), unvaccinated OIPs between 0 22 days, healthy donors (HDs) 14 days 6 months after the second doses homogenous heterologous Ad5-nCoV. Anti-Wuhan-, Anti-Delta-, Anti-Omicron-receptor...

10.1002/jmv.28163 article EN Journal of Medical Virology 2022-09-21

Cervical abnormal cell detection plays a crucial role in the early screening of cervical cancer. In recent years, some deep learning-based methods have been proposed. However, these rely heavily on large amounts annotated images, which are time-consuming and laborintensive to acquire, thus limiting performance. this paper, we present novel Semi-supervised Abnormal Cell detector (SCAC), effectively utilizes abundant unlabeled data. We utilize Transformer as backbone SCAC capture long-range...

10.1109/jbhi.2024.3375889 article EN IEEE Journal of Biomedical and Health Informatics 2024-03-18

Background: MiR-15a-3p has been reported as a tumor suppressor in several kinds of cancer, including cervical cancer and gastric cancer. However, the precise molecular mechanisms underlying its role prostate (PCa) remain largely unknown. Methods: The expression miR-15a-3p was determined PCa tissues cell lines using quantitative real time PCR. biological function cells investigated MTT assay, Edu staining transwell assay. Moreover, luciferase reporter PCR western blotting were used to...

10.1089/cbr.2018.2722 article EN Cancer Biotherapy and Radiopharmaceuticals 2019-05-28

Abstract Background Clopidogrel is an inactive prodrug, it catalyzed into its active form by Cytochrome 450 and Paraoxonase-1(PON-1). polymorphisms of genes encoding these enzymes will affect the efficacy Clopidogrel. The main objective our study was to investigate association CYP2C19*2, CYP2C19*3 PON-1Q192R with resistance major adverse cardiac events in Jin Hua district middle Zhe Jiang Province China. Methods One hundred sixty coronary heart disease patients percutaneous intervention, who...

10.1186/s40360-019-0378-7 article EN cc-by BMC Pharmacology and Toxicology 2020-01-03

T helper 17 (Th17) and Th22 cells regulate the development of tumors. However, their roles in colorectal cancer (CRC) are still unclear. A total 49 patients with CRC 18 healthy controls (HC) were evaluated for percentages circulating Th17 by flow cytometry. The concentrations serum interleukin-17A (IL-17A), IL-22 carcinoembryonic antigen (CEA) examined. levels IL-17A tumors determined real-time PCR. We found that significantly lower than HC associated negatively pathological stages CRC. mRNA...

10.3109/08820139.2014.936445 article EN Immunological Investigations 2014-07-15

Background A third mRNA vaccine booster is recommended to improve immunity against SARS-CoV-2 in kidney transplant recipients (KTRs). However, the Ancestral strain and Delta Omicron variants elicited by dose of inactivated KTRs remains unknown. Methods The blood parameters related cells count, hepatic function, heart injury were explored clinically from laboratory examinations. specific antibody IgG titer was detected using an enzyme-linked immunosorbent assay. Cellular analyzed interferon-γ...

10.3389/fimmu.2022.1042784 article EN cc-by Frontiers in Immunology 2023-01-09

Hepatitis C virus (HCV) infection is a leading cause of hepatoma worldwide. HCV classified into seven major genotypes, and genotype 6 commonly prevalent in Asia. An efficient infectious culture system representative isolates that are currently important for research. Here, we developed robust cell 6a clinical isolate CH6a using novel strategy. Initially, determined consensus sequence patient serum, assembled full-length recombinant the overlapped PCR-derived clones shared high homology with...

10.3389/fmicb.2018.02950 article EN cc-by Frontiers in Microbiology 2018-12-04

As soot particles from incomplete combustion of fossil fuels pose a great threat to human health, the development low-carbon or zero-carbon alternative is essential mitigate climate change. An experimental and numerical study on pyrolysis properties ammonia ethylene mixtures conducted, focusing generated by under different conditions coupling relationship between precursors. The results show that graphitization degree at higher temperatures enhanced, but oxidation reactivity decreased. When...

10.3389/fenrg.2022.996813 article EN cc-by Frontiers in Energy Research 2022-09-14

In this study, we examined the effect of Il9 deletion on macrophages in methicillin-resistant Staphylococcus aureus (MRSA) infection. MRSA-infected mice were employed for vivo experiments, and RAW264.7 cells stimulated with MRSA vitro experiments. Macrophage polarization was determined by flow cytometry quantitative real-time PCR; macrophage phagocytosis assessed laser scanning confocal microscopy; cell apoptosis western blotting. markedly elevated M2 infection, which accompanied expression...

10.1128/iai.00166-23 article EN Infection and Immunity 2023-09-28

Currently, no vaccine to prevent hepatitis C virus (HCV) infection is available. A major challenge in developing an HCV the high diversity of sequences. The purpose immunization with viral glycoproteins induce a potent and long-lasting cellular humoral immune response. However, this strategy only achieves limited protection, antigen selection plays crucial role design. In study, we investigated responses induced by intraperitoneal injection keyhole limpet hemocyanin conjugated 4 highly...

10.1155/2021/3108157 article EN cc-by Journal of Immunology Research 2021-01-16
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