A5100721766- Sinusitis and nasal conditions
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Head and Neck Surgical Oncology
- Liver Disease Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Influenza Virus Research Studies
- Parasites and Host Interactions
- Asthma and respiratory diseases
- Nasal Surgery and Airway Studies
- Allergic Rhinitis and Sensitization
- Tuberculosis Research and Epidemiology
- Reconstructive Surgery and Microvascular Techniques
- Genetic Mapping and Diversity in Plants and Animals
- Immunotherapy and Immune Responses
- Respiratory viral infections research
- Oral and Maxillofacial Pathology
- Immune Cell Function and Interaction
- Reconstructive Facial Surgery Techniques
- interferon and immune responses
- Clinical Nutrition and Gastroenterology
- Viral gastroenteritis research and epidemiology
- Platelet Disorders and Treatments
- Esophageal and GI Pathology
- Blood groups and transfusion
Nanjing University
2024-2025
Nanjing General Hospital of Nanjing Military Command
2020-2025
Capital Medical University
2019-2025
Zhejiang Provincial People's Hospital
2025
Hangzhou Medical College
2025
Westlake University
2025
Second Xiangya Hospital of Central South University
2003-2025
Central South University
2003-2025
Nanjing Medical University
2016-2024
Second Affiliated Hospital of Jilin University
2018-2024
Background: Very-late-onset myasthenia gravis (VLOMG) refers to (MG) with onset at age 65 or older. Current research on VLOMG prognosis remains limited, especially regarding factors influencing outcomes. Objectives: To identify the clinical that affect short- and long-term of MG patients an ⩾65 years. Design: This was a single-center, retrospective cohort study AChR-ab positive patients, classified into two subgroups based onset: sub-very-late-onset (S-VLOMG, <75 years), super-late-onset...
Stem cell transplantation showed promising results in IBD management. However, the therapeutic impacts of delivery route that is critical for clinical translation are currently poorly understood. Here, three different MSCs routes: intraperitoneal (IP), intravenous (IV), and anal injection (AI) were compared on DSS-induced colitic mice model. The overall factors, migration targeting as well local immunomodulatory cytokines FoxP3(+) cells infiltration analyzed. Colitis varying degrees...
Abstract Genetic factors affect host susceptibility to pathogens. In this population-based case control study, we explored the genetic polymorphisms of IL-17, TLR4 and miR-146a in association with pulmonary tuberculosis a Chinese Han population. We recruited 1601 patients matched 1526 healthy controls genotyped twelve functional single nucleotide (SNPs). After correction for multiple comparisons, two SNPs (rs10759932 rs2737190) gene remained significant. Individuals carrying rs2737190-AG...
BackgroundChronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease spectrum of endotypes. TH2- and TH17-related cytokines are 2 central regulators involved in the inflammation associated CRSwNP.ObjectiveWe sought to investigate interregulation TH2 TH17 pathways Chinese patients CRSwNP.MethodsLevels key factors were measured homogenates polyp tissue obtained from CRSwNP. The relationship these their expression groups classified according IL-5 IL-17 concentrations analyzed....
The peroneal artery perforator flap is widely used to repair deep defects in the distal lower leg and ankle. However, success of transplantation depends on accurate location perforators, which can be a challenge due potential vascular damage anatomical variations. This study utilizes digital subtraction angiography high-frequency ultrasound clarify features its perforators accurately locate these thereby improving preoperative design clinical outcomes. Peroneal sequential flaps were employed...
Damages to the supportive structure of pelvic floor frequently result in organ prolapse (POP), which diminishes quality life. Surgical repair typically involves mesh implantation reinforce weakened tissues. However, commonly used polypropylene (PP) can lead severe complications due mechanical mismatch with In this study, 3D-printed silk fibroin (SF) meshes are developed and optimized through cryogenic 3D printing followed by post-stretching treatment enhance properties biocompatibility for...
Since 2013, H7N9 avian influenza viruses (AIVs) have caused more than 1,600 human infections, posing a threat to public health. An emerging concern is whether AIVs will cause pandemics among humans. Molecular analysis of hemagglutinin (HA), which critical determinant interspecies transmission, shows that the current are still dual-receptor tropic, indicating limited human-to-human transmission potency. Mutagenesis and structural studies reveal G186V substitution sufficient for acquire...
Tissue remodeling caused by increased MMPs is involved in the pathogenesis of chronic rhinosinusitis with nasal polyposis (CRSwNP). We previously found higher levels periostin and tenascin C CRSwNPs, but whether they are associated dysregulation unknown. Therefore, present study aimed to investigate regulatory roles these two ECM proteins expression polyps.The concentrations MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-12, MMP-13, TIMP-1, TIMP-2, TIMP-3, TIMP-4, periostin, tissue homogenates 51...
This study was conducted to investigate the effects of apple polyphenol extract (APE) against influenza virus in mice loaded with restraint stress. The high-performance liquid chromatography (HPLC) fingerprint APE recorded, and percentage composition polyphenols determined as 81.7%. Our results showed that stress significantly promoted mortality duration complications infected H1N1 virus. However, oral administration (100 200 mg/kg) improved survival rates prolonged living time stressed a...
The incidence of tuberculosis (TB) and its risk factors in China remains unclear. This study examined TB relative rural areas China. Participants (n = 177,529) were recruited Xiangtan County (in the central area China) Danyang eastern 2009 a followed-up was conducted for one year. density pulmonary smear-positive 91.6 (95% CI: 78.7, 106.0) per 100,000 person-year 36.7 33.1, 52.4) respectively Xiangtan, 47.3 38.2, 57.5) 22.7 16.5, 30.8) Danyang. medical history associated with TB, (RR) 7.00...
We investigated the migration patterns of hepatitis C virus (HCV) in China. Partial E1 and/or NS5B sequences from 411 volunteer blood donors sampled 17 provinces and municipalities located five large regions, north-northeast, northwest, southwest, central south, southeast, were characterized. The classified into eight subtypes (1a, n = 3; 1b, 183; 2a, 83; 3a, 30; 3b, 44; 6a, 55; 6n, 10; 6v, 1) a new subtype candidate. Bayesian evolutionary analysis by sampling trees major revealed distinct...
Background: Nonalcoholic fatty liver disease (NAFLD) is now recognized as the most prevalent chronic worldwide. However, dysregulated gene expression for NAFLD still poorly understood. Material and methods: We analyzed two public datasets (GSE48452 GSE89632) to identify differentially expressed genes (DEGs) in NAFLD. Then, we performed a series of bioinformatics analyses explore potential hub Results: This study included 26 simple steatosis (SS), 34 nonalcoholic steatohepatitis (NASH), 13...
Introduction The study aimed to determine the effect of scanning area used for high-speed ultra-widefield swept-source optical coherence tomography angiography (SS-OCTA) on detection rate diabetic retinopathy (DR) lesions. Methods This prospective, observational involved patients between October 2021 and April 2022. participants underwent a comprehensive ophthalmic examination SS-OCTA using 24 mm × 20 protocol. A central denoted as “12 12 mm-central” was extracted from image, remaining...
Abstract Objective This cross‐sectional study aimed to determine the epidemiology of olfactory and gustatory dysfunctions related COVID‐19 in China. Methods was conducted by 45 tertiary Grade‐A hospitals Online offline questionnaire data were obtained from patients infected with between December 28, 2022, February 21, 2023. The collected information included basic demographics, medical history, smoking drinking vaccination changes functions before after infection, other postinfection...
Different hepatitis C virus (HCV) genotypes exhibit differences in disease pathogenesis and progression, as well outcomes response to therapy. Tracking the change of HCV various epidemiological settings is critical for both surveillance development improved antiviral treatment. Here, we tracked changes prevalence China between 2004-2007 2008-2011. HCV-RNA-positive sera were collected from volunteer blood donors during period The determined by phylogenic analysis using NS5B E1 sequences....
Japanese encephalitis virus (JEV) can cause serious and Culex mosquitoes are the primary vector. In 2013, a JE outbreak occurred in Shandong Province, China with 407 confirmed cases, including 11 deaths. An investigation on JEV during was conducted. A total of 14,719 were collected at 3 sites. For 12,695 tritaeniorhynchus mosquitoes, 88/201 pooled samples positive by RT-PCR for presence pre-membrane or envelope protein coding genes. The maximum likelihood estimates individuals per 1,000...
Abstract The incidence of fertile women with missed abortion dramatically increased in recent years, while very few serum indices have been identified for the diagnosis abortion. aim this study was to identify related factors through a retrospective indices. A total 795 cases and 694 normal pregnancy between March 2014 2017 were included present study. based on clinical history, examination, transvaginal ultrasound findings. final assessment structures (i.e., gestational sac without fetal...