A5008482472- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Viral-associated cancers and disorders
- Inflammatory Biomarkers in Disease Prognosis
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Lymphoma Diagnosis and Treatment
- Immune cells in cancer
- Inflammasome and immune disorders
- Hepatitis C virus research
- Hepatitis B Virus Studies
- Immunotherapy and Immune Responses
- Parvovirus B19 Infection Studies
- Nanoplatforms for cancer theranostics
- Peptidase Inhibition and Analysis
- Nanoparticle-Based Drug Delivery
- HIV/AIDS drug development and treatment
- Liver Disease Diagnosis and Treatment
- RNA modifications and cancer
- Advanced Nanomaterials in Catalysis
- Virus-based gene therapy research
- CRISPR and Genetic Engineering
- Medical Imaging Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Ferroptosis and cancer prognosis
Zhuhai People's Hospital
2022-2024
Jinan University
2022-2024
Foshan University
2024
Second Affiliated Hospital of Guangzhou Medical University
2024
Guangzhou Medical University
2024
Sun Yat-sen University
2015-2023
Sun Yat-sen University Cancer Center
2021-2023
State Key Laboratory of Oncology in South China
2023
Jinan University
2023
Macau University of Science and Technology
2023
PIWI-interacting RNA (piRNA) silences the transposons in germlines or induces epigenetic modifications invertebrates. However, its function mammalian somatic cells remains unknown. Here we demonstrate that a piRNA derived from Growth Arrest Specific 5, tumor-suppressive long non-coding RNA, potently upregulates transcription of tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL), proapoptotic protein, by inducing H3K4 methylation/H3K27 demethylation. Interestingly, PIWIL1/4...
Abstract The discovery of PIWI-interacting RNAs (piRNAs) revealed the complexity RNA world. Although piRNAs were first deemed to be germline specific, substantial evidence shows their various roles in somatic cells; however, function highly differentiated immune cells remains elusive. In this study, by initially screening with a small deep-sequencing analysis, we found that piRNA, tRNA-Glu–derived piRNA [td-piR(Glu)], was expressed much more abundantly human monocytes than dendritic cells....
Epstein-Barr virus (EBV) infects more than 90% of the world's adult population and accounts for a significant cancer burden epithelial B cell origins. Glycoprotein (gB) is primary fusogen essential EBV entry into host cells. Here, we isolated two gB-specific neutralizing antibodies, 3A3 3A5; both effectively neutralized dual-tropic infection In humanized mice, antibodies showed effective protection from EBV-induced lymphoproliferative disorders. Cryoelectron microscopy analyses identified...
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated epithelial malignancy characterized by the presence of prominent infiltration lymphocytes, including natural killer (NK) cells. Although NK cells can directly target EBV-infected tumor without restriction MHC, EBV-positive (EBV+) NPC often develop resistance mechanisms that allow them to evade immune surveillance Elucidating involved in EBV-induced NK-cell dysfunction will contribute design novel cell-based...
Nasopharyngeal carcinoma (NPC) and Epstein-Barr virus (EBV)-associated gastric (EBVaGC) are two major EBV-associated epithelial malignancies, both of which characterized by the infiltration a large number lymphocytes, including natural killer (NK) cells. Although NK cells can prevent development EBV-infected tumor often develop resistance to surveillance Elucidating interactions between will facilitate more effective NK-mediated therapies for treating malignancies. Here we investigated...
// Ting Pan 1, 2, 3 , Yiwen Zhang Nan Zhou Xin He Cancan Chen Liting Liang Xiaobing Duan 2 Yingtong Lin Kang Wu Hui 1 Institute of Human Virology, Sun Yat-Sen University, Guangzhou, Guangdong, China Key Laboratory Tropical Diseases Control, Ministry Education, Zhongshan School Medicine, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Correspondence to: Zhang, email: zhangh92@mail.sysu.edu.cn Keywords: pancreatic cancer, Vif, Ras binding domain, ubiquitin,...
Hepatitis C virus (HCV) infection is a leading cause of hepatoma worldwide. HCV classified into seven major genotypes, and genotype 6 commonly prevalent in Asia. An efficient infectious culture system representative isolates that are currently important for research. Here, we developed robust cell 6a clinical isolate CH6a using novel strategy. Initially, determined consensus sequence patient serum, assembled full-length recombinant the overlapped PCR-derived clones shared high homology with...
T cells are crucial for the control of persistent EBV infection and development EBV-associated diseases. The gB protein is essential virus entry into B epithelial thus a target antigen vaccine development.
Hepatitis C virus (HCV) infection is a major cause of chronic hepatitis and liver cancer worldwide. Adaptive mutations play important roles in the development HCV replicon its infectious clones. We others have previously identified p7 mutation F772S co-presence NS4A full-length clones chimeric recombinants. However, underlying mechanism function remains incompletely understood. Here, we investigated functional role using an efficient JFH1-based reporter with Core-NS2 from genotype 2a strain...
<title>Abstract</title> Melanoma is a malignancy of aggressive behaviour and related with poor prognosis. Immunotherapy for metastatic melanoma shows great promise. However, the development rapid resistance remains largely insurmountable challenge. In this study, we aim to identify macrophage marker genes construct an immune risk model, hoping provide clinical significance in prognosis immunotherapy response prediction. A total 16,291 cell samples from 48 tissues GSE120575 were enrolled....
<p>Supplementary Figures and Tables</p>
<div>Abstract<p>Nasopharyngeal carcinoma (NPC) is an Epstein–Barr virus (EBV)-associated epithelial malignancy characterized by the presence of prominent infiltration lymphocytes, including natural killer (NK) cells. Although NK cells can directly target EBV-infected tumor without restriction MHC, EBV+ NPC often develop resistance mechanisms that allow them to evade immune surveillance Elucidating involved in EBV-induced NK-cell dysfunction will contribute design novel cell–based...
<p>Supplementary Figures and Tables</p>
Cetuximab, an anti-epidermal growth factor receptor (EGFR) antibody, has been shown to improve survival in nasopharyngeal carcinoma (NPC) patients. However, a correlation between the expression of EGFR and response cetuximab not observed, indicating that mechanism underlying effects needs be further elucidated. The antitumour involves immunotherapeutic mechanisms target tumour-associated antigens, including complement-dependent cytotoxicity (CDC) antibody-dependent cellular (ADCC), act...
Abstract Background Although a variety of immune checkpoint monoclonal antibodies have been approved for the treatment cancers, low response rate inhibitors limits their wide clinical application. Therefore, to explore new and broader immunotherapy targets improve CD8 + T cells will provide theoretical basis refractory malignant solid tumors. Methods We used single-cell sequencing data screen genes associated with exhaustion infiltrating in tumor microenvironment validated them by...
<p>Supplementary Figures and Tables</p>
<div>Abstract<p>Nasopharyngeal carcinoma (NPC) is an Epstein–Barr virus (EBV)–associated epithelial malignancy characterized by the presence of prominent infiltration lymphocytes, including natural killer (NK) cells. Although NK cells can directly target EBV-infected tumor without restriction MHC, EBV-positive (EBV<sup>+</sup>) NPC often develop resistance mechanisms that allow them to evade immune surveillance Elucidating involved in EBV-induced NK-cell dysfunction...
<p>Supplementary Figures and Tables</p>