A5024351731- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- Inflammatory Biomarkers in Disease Prognosis
- Viral-associated cancers and disorders
- Antibiotic Resistance in Bacteria
- Antibiotic Use and Resistance
- Bacterial Identification and Susceptibility Testing
- Antibiotics Pharmacokinetics and Efficacy
- Vibrio bacteria research studies
- Lymphoma Diagnosis and Treatment
- Amphibian and Reptile Biology
- Enterobacteriaceae and Cronobacter Research
- Ferroptosis and cancer prognosis
- Infective Endocarditis Diagnosis and Management
- Escherichia coli research studies
- Plant Pathogens and Fungal Diseases
- Cancer therapeutics and mechanisms
- Urinary Tract Infections Management
- Actinomycetales infections and treatment
- Yeasts and Rust Fungi Studies
- Clostridium difficile and Clostridium perfringens research
- Antifungal resistance and susceptibility
- Infectious Diseases and Mycology
- Cancer, Lipids, and Metabolism
- Nosocomial Infections in ICU
Sun Yat-sen University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2016-2025
Nasopharyngeal carcinoma (NPC) is an Epstein-Barr virus (EBV)-associated epithelial malignancy characterized by the presence of prominent infiltration lymphocytes, including natural killer (NK) cells. Although NK cells can directly target EBV-infected tumor without restriction MHC, EBV-positive (EBV+) NPC often develop resistance mechanisms that allow them to evade immune surveillance Elucidating involved in EBV-induced NK-cell dysfunction will contribute design novel cell-based...
Nasopharyngeal carcinoma (NPC) and Epstein-Barr virus (EBV)-associated gastric (EBVaGC) are two major EBV-associated epithelial malignancies, both of which characterized by the infiltration a large number lymphocytes, including natural killer (NK) cells. Although NK cells can prevent development EBV-infected tumor often develop resistance to surveillance Elucidating interactions between will facilitate more effective NK-mediated therapies for treating malignancies. Here we investigated...
Bloodstream infection (BSI) caused by carbapenem resistant Klebsiella pneumoniae (CRKP), especially in elderly patients, results higher morbidity and mortality. The purpose of this study was to assess risk factors associated with CRKP BSI short-term mortality among patients China.In retrospective cohort study, we enrolled 252 inpatients aged ≥ 65 years KP from January 2011 December 2020 China. Data regarding demographic, microbiological characteristics, clinical outcome were collected.Among...
Though droplet digital PCR (ddPCR) has emerged as a promising tool for early pathogen detection in bloodstream infections (BSIs), more studies are needed to support its clinical application widely due different ddPCR platforms with discrepant diagnostic performance. Additionally, there is still lack of data reveal the association between loads detected by and corresponding BSIs. In this prospective study, 173 patients suspected BSIs were enrolled. A multiplex assay was used detect 18...
Introduction: The rapid and accurate identification of carbapenemases in Enterobacterales isolates is paramount importance for the selection effective antibiotics control hospital-acquired infections. Methods: This study aimed to evaluate performance two immunochromatographic methods, NG-Test Carba 5 (Carba 5) Goldstream Carbapenem-resistant K.N.I.V.O. Detection K-Set (K-Set) detecting five major carbapenemase (KPC, NDM, IMP, OXA-48-like, VIM). Carbapenemase genes were confirmed by PCR....
Abstract The study aims were to present in vitro susceptibilities of clinical isolates from Gram-negative bacteria bloodstream infections (GNBSI) collected China. GNBSI 18 tertiary hospitals 7 regions China 2018 2020. Minimum inhibitory concentrations assessed using a Trek Diagnostic System. Susceptibility was determined CLSI broth microdilution, and breakpoints interpreted M100 (2021). A total 1,815 strains collected, with E. coli (42.4%) Klebsiella pneumoniae (28.6%) being the most...
Identification of abnormal promyelocytes is crucial for early diagnosis Acute promyelocytic leukaemia (APL) and reducing the mortality rate APL patients, which can be achieved by microscopic blood smear observation. However, observation has shortcomings, including interobserver variability training difficulty. This first study evaluating performance MC-100i, an artificial intelligence (AI)-based digital morphology analyser, in identifying smears thus assisting screening APL. One hundred...
Background The emergence of ceftazidime–avibactam (CZA) resistance among carbapenem-resistant Klebsiella pneumoniae (CRKP) is major concern due to limited therapeutic options. Methods In this study, 10 CRKP strains were isolated from different samples a patient with infection receiving CZA treatment. Whole-genome sequencing (WGS) and conjugation experiments performed determine the transferability carbapenem gene. Results This began KPC-2-producing K. (CZA MIC = 2 μg/mL, imipenem ≥ 16 μg/mL)....
ApoE has been reported to be associated with tumorigenesis and tumor progression. In this study, we explored the potential diagnostic prognostic role of serum in breast cancer patients. Subject cohorts consisted 152 normal healthy controls female 257 cases. Serum levels were determined turbidimetric immunoassay. The significantly elevated patients compared (45.82 ± 13.96 mg/L vs. 33.61 6.44 mg/L, respectively, P < 0.0001) also TNM stage lymph nodes status (all 0.05). Area under receiver...
Resistance against ceftazidime-avibactam (CZA) in carbapenem-resistant Pseudomonas aeruginosa (CRPA) is emerging. This study was aimed at detecting the prevalence and molecular characteristics of CZA-resistant CRPA clinical isolates Guangdong Province, China. The antimicrobial susceptibility profile these strains determined. A subset 16 analysed by whole-genome sequencing (WGS). Genetic surroundings carbapenem resistance genes pan-genome-wide association analysis were further studied. Of 250...
Bloodstream infections (BSIs) caused by Acinetobacter baumannii (AB), especially carbapenem-resistant (CRAB), can lead to a high patient mortality rate. This study aimed analyze the clinical data and prognosis of 191 patients with AB-BSI hospitalized in Southern China from January 2017 December 2023. CRAB was diagnosed 128 (67.0%) AB-BSI. Endotracheal intubation (OR = 23.957, 95% CI: 5.123-112.022, P < 0.001), carbapenem treatment 6.422, 1.554-26.542, 0.010) ≥2 antimicrobial drugs therapy...
Stephanoascus ciferrii is a heterothallic ascomycetous yeast-like fungus. Recently, the concept of S. complex has been proposed and it consists ciferrii, Candida allociferrii, mucifera. We aimed to identify 32 strains isolated from patients with chronic suppurative otitis media (CSOM) at species level analyze morphology antifungal susceptibility profiles three species.The sequencing internal transcribed spacer (ITS) region matrix-assisted laser desorption ionization time-of-flight mass...
Abstract Background Streptomyces cacaoi , Gram-positive, branched, filamentous bacillus forms without fragmentation, are saprophytic soil organisms rarely known to cause invasive infections other than mycetoma. Here we describe a case of chronic suppurative otitis media caused by in patient with hyperlipidemia China. Case presentation A 62-year-old female suffered . She had favorable outcome 4-week course ofloxacin ear drops. Conclusions is reported human infection. The introduction...
<p>Supplementary Figures and Tables</p>
<div>Abstract<p>Nasopharyngeal carcinoma (NPC) is an Epstein–Barr virus (EBV)-associated epithelial malignancy characterized by the presence of prominent infiltration lymphocytes, including natural killer (NK) cells. Although NK cells can directly target EBV-infected tumor without restriction MHC, EBV+ NPC often develop resistance mechanisms that allow them to evade immune surveillance Elucidating involved in EBV-induced NK-cell dysfunction will contribute design novel cell–based...
<p>Supplementary Figures and Tables</p>
Abstract A rapid and accurate detection of carbapenemases for Enterobacterales isolates is crucial to the selection antibiotics control hospital infection. This study aimed evaluate performance two immunochromatographic methods, NG-Test Carba 5 (Carba 5) Goldstream Carbapenem-resistant K.N.I.V.O. Detection K-Set (K-Set), detecting five major genes ( bla KPC, NDM, IMP , OXA−48−like VIM ). Carbapenemase were confirmed by PCR. In this study, 245 carbapenem-resistant (CRE) strains included,...
<div>Abstract<p>Nasopharyngeal carcinoma (NPC) and Epstein–Barr virus (EBV)–associated gastric (EBVaGC) are two major EBV-associated epithelial malignancies, both of which characterized by the infiltration a large number lymphocytes, including natural killer (NK) cells. Although NK cells can prevent development EBV-infected tumor often develop resistance to surveillance Elucidating interactions between will facilitate more effective NK-mediated therapies for treating...
Supplementary Data from EBV Infection in Epithelial Malignancies Induces Resistance to Antitumor Natural Killer Cells via F3-Mediated Platelet Aggregation
Supplementary Figure from EBV Infection in Epithelial Malignancies Induces Resistance to Antitumor Natural Killer Cells via F3-Mediated Platelet Aggregation
Supplementary Figure from EBV Infection in Epithelial Malignancies Induces Resistance to Antitumor Natural Killer Cells via F3-Mediated Platelet Aggregation
Supplementary Figure from EBV Infection in Epithelial Malignancies Induces Resistance to Antitumor Natural Killer Cells via F3-Mediated Platelet Aggregation
Supplementary Figure from EBV Infection in Epithelial Malignancies Induces Resistance to Antitumor Natural Killer Cells via F3-Mediated Platelet Aggregation
Supplementary Figure from EBV Infection in Epithelial Malignancies Induces Resistance to Antitumor Natural Killer Cells via F3-Mediated Platelet Aggregation