Cancan Chen

ORCID: 0000-0002-5797-8988
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About
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Research Areas
  • Rock Mechanics and Modeling
  • Cancer-related molecular mechanisms research
  • Landslides and related hazards
  • RNA modifications and cancer
  • Radiomics and Machine Learning in Medical Imaging
  • melanin and skin pigmentation
  • Genetic and phenotypic traits in livestock
  • AI in cancer detection
  • Drilling and Well Engineering
  • Geophysical Methods and Applications
  • Animal Genetics and Reproduction
  • Effects of Environmental Stressors on Livestock
  • Genetic Mapping and Diversity in Plants and Animals
  • Geotechnical Engineering and Analysis
  • Constructed Wetlands for Wastewater Treatment
  • Digital Imaging for Blood Diseases
  • Thyroid Cancer Diagnosis and Treatment
  • Hydraulic Fracturing and Reservoir Analysis
  • Phosphorus and nutrient management
  • Galectins and Cancer Biology
  • Radioactivity and Radon Measurements
  • Human Pose and Action Recognition
  • Circular RNAs in diseases
  • User Authentication and Security Systems
  • Mosquito-borne diseases and control

Chongqing Academy of Animal Science
2022-2025

Chongqing University
2019-2025

The First Affiliated Hospital, Sun Yat-sen University
2019-2024

Sun Yat-sen University
2016-2024

Guilin Medical University
2024

Digital China Health (China)
2022-2024

Ningbo Product Quality Supervision and Inspection Institute
2023

China Mobile (China)
2019-2023

University of Hong Kong
2023

Xinqiao Hospital
2021

Abstract Long noncoding RNAs (lncRNAs) play multiple key regulatory roles in various cellular pathways. However, their functions HIV-1 latent infection remain largely unknown. Here we show that a lncRNA named NRON, which is highly expressed resting CD4 + T lymphocytes, could be involved latency by specifically inducing Tat protein degradation. Our results suggest NRON potently suppresses the viral transcription decreasing abundance of transactivator Tat. directly links to...

10.1038/ncomms11730 article EN cc-by Nature Communications 2016-06-13

Circular RNAs (circRNAs) are a novel group of noncoding characterized by covalently closed loop. An increasing evidence suggests that deregulated circRNAs exert their essential regulatory roles in oncogenesis. However, little is explored on the biological role cervical cancer (CC) progression. In present study, we analyzed two GSE microarrays to screen for CC-specific and found both expressed CC cells tissues. Among them, circ_0005576 was significantly overexpressed tissues cell lines....

10.1016/j.biopha.2019.109311 article EN Biomedicine & Pharmacotherapy 2019-08-10

Vitamin E (VE) is an indispensable vitamin in piglet feed formula. Among other things, it affects tissues including small intestine and particular its major unit intestinal epithelial cells. Previously, limited vivo experiments have focused on the effect of VE intestine, particularly digestion absorption. has been shown to inhibit proliferation some types This experiment was conducted test hypothesis that functions by influencing cell proliferation. Thirty 21-d old weaned [(Yorkshire ×...

10.1093/jas/skz023 article EN Journal of Animal Science 2019-01-14

Objective: The study was conducted to identify the molecular mechanism of phenotype formation Youzhou black sheep by histological cytology and transcriptomics. Materials Methods: In this study, HE IHC staining were used explore patterns cytological differences in skin pigment deposition between Dark goats Banjiao goats. addition, DEGs related identified via transcriptomic analyses. Finally, expression pattern agouti signal protein (ASIP) gene from individuals with different color phenotypes...

10.5455/javar.2024.k865 article EN cc-by Journal of Advanced Veterinary and Animal Research 2025-01-01

Esophageal squamous cell carcinoma (ESCC) is a deadly disease with frequent recurrence. There are unmet needs for prognostic biomarkers dynamically monitoring progression and detecting minimal residual disease.

10.1001/jamasurg.2023.4395 article EN JAMA Surgery 2023-09-20

This study aimed to investigate the significant single nucleotide polymorphisms (SNPs) and genes associated with nine reproduction morphological traits in three breed populations of Chinese goats.The genome-wide association (litter size, nipple number, wattle, skin color, coat black dorsal line, beard, beard length, hind leg hair) were analyzed native goat breeds (n = 336) using an Illumina Goat SNP50 Beadchip.A total 17 or chromosome-wide SNPs one trait size) six (wattle, identified breeds,...

10.5713/ab.21.0577 article EN cc-by Animal Bioscience 2022-06-23

Abstract In order to study the effect of water-rock interactions on shear strength characteristics, we performed shearing tests under varying hydrochemical environments. Moreover, a custom meso-shear test equipment for coal rock was used tests. Through 3D scanning fractures and electron microscope imaging, studied different pH chemical solutions fracture characteristics sandstones. We obtained three main results. With increasing solution acidity or alkalinity, water-hemical corrosivity...

10.1038/s41598-019-56196-2 article EN cc-by Scientific Reports 2019-12-27

Abstract Background Breast cancer is the most common malignant tumor in world. Intraoperative frozen section of sentinel lymph nodes an important basis for determining whether axillary node dissection required breast surgery. We propose RRCART model based on a deep-learning network to identify metastases 2362 sections and count wrongly identified associated reasons. The purpose summarize factors that affect accuracy artificial intelligence corresponding solutions. Methods took pathological...

10.1186/s13000-023-01432-7 article EN cc-by Diagnostic Pathology 2024-01-22

// Ting Pan 1, 2, 3 , Yiwen Zhang Nan Zhou Xin He Cancan Chen Liting Liang Xiaobing Duan 2 Yingtong Lin Kang Wu Hui 1 Institute of Human Virology, Sun Yat-Sen University, Guangzhou, Guangdong, China Key Laboratory Tropical Diseases Control, Ministry Education, Zhongshan School Medicine, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Correspondence to: Zhang, email: zhangh92@mail.sysu.edu.cn Keywords: pancreatic cancer, Vif, Ras binding domain, ubiquitin,...

10.18632/oncotarget.9996 article EN Oncotarget 2016-06-14

The pathological rare category of thyroid is a type lesion with low incidence rate and easily misdiagnosed in clinical practice, which directly affects patient's treatment decision. However, it has not been adequately investigated to recognize the rare, benign, malignant categories using deep learning method recommend pathologists.

10.3389/fbioe.2022.857377 article EN cc-by Frontiers in Bioengineering and Biotechnology 2022-07-06

Currently, a single treatment is less effective for triple-negative breast cancer (TNBC) therapy. Additionally, there are some limitations to the use of siRNA alone as new method treat cancer, such its delivery into cells. In this study, we proposed strategy that combines siRNA-loaded DNA nanostructure and genistein TNBC Both CD36 self-assembled nanoprisms (NP-siCD36) knocked down CD36, resulting in enhanced anticancer efficacy through phosphorylation p38 MAPK pathway.In vitrostudies showed...

10.1088/1361-6528/ac0d1e article EN cc-by Nanotechnology 2021-06-21

Zika virus (ZIKV) infection can cause severe neurological diseases including neonatal microcephaly and Guillain-Barre syndrome. Long noncoding RNAs (lncRNAs) are the by-products of transcription process, which considered to affect viral infection. However, it remains largely unexplored whether host lncRNAs play a role in ZIKV Here, we identified group human that were up-regulated upon dependent on type I interferon (IFN) signaling. Overexpression lncRNA ZAP-IT1 leads an impairment...

10.1016/j.virs.2022.08.003 article EN cc-by-nc-nd Virologica Sinica 2022-08-17

Time-dependent behavior has been demonstrated to be an essential factor in determining the long-term stability of underground structures. Creep and relaxation experiments are commonly used investigate time-dependent by subjecting rock constant stress strain. However, both strain in-situ masses likely change with time, a phenomenon known as generalized that not thoroughly investigated. In this study, newly proposed control method linear combination feedback signal is compression tension tests...

10.3389/feart.2021.769621 article EN cc-by Frontiers in Earth Science 2021-10-21

Abstract Password plays a vital role in identity authentication. However, password security is facing great challenges. In this paper, we research the cracking technology based on artificial intelligence, aiming to study probability of common setting methods, and provide references for password. First all, collected large amount user’s personal information passwords, analysed correlation between passwords. And then, implemented guessing model improved Transformer which weights were...

10.1088/1742-6596/1631/1/012161 article EN Journal of Physics Conference Series 2020-09-01
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